Search Results - "Fulcher, C A"

The MetaCyc database of metabolic pathways and enzymes and the BioCyc collection of pathway/genome databases by Caspi, Ron, Altman, Tomer, Dreher, Kate, Fulcher, Carol A., Subhraveti, Pallavi, Keseler, Ingrid M., Kothari, Anamika, Krummenacker, Markus, Latendresse, Mario, Mueller, Lukas A., Ong, Quang, Paley, Suzanne, Pujar, Anuradha, Shearer, Alexander G., Travers, Michael, Weerasinghe, Deepika, Zhang, Peifen, Karp, Peter D.

“…The MetaCyc database (http://metacyc.org/) provides a comprehensive and freely accessible resource for metabolic pathways and enzymes from all domains of life…”
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MetaCyc Database of metabolic pathways and enzymes and the BioCyc collection of Pathway/Genome Databases by Caspi, Ron, Foerster, Hartmut, Fulcher, Carol A, Kaipa, Pallavi, Krummenacker, Markus, Latendresse, Mario, Paley, Suzanne, Rhee, Seung Y, Shearer, Alexander G, Tissier, Christophe, Walk, Thomas C, Zhang, Peifen, Karp, Peter D

“…MetaCyc (MetaCyc.org) is a universal database of metabolic pathways and enzymes from all domains of life. The pathways in MetaCyc are curated from the primary…”
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A major factor VIII binding domain resides within the amino-terminal 272 amino acid residues of von Willebrand factor by Foster, P A, Fulcher, C A, Marti, T, Titani, K, Zimmerman, T S

“…We have identified a Factor VIII (FVIII) binding domain residing within the amino-terminal 272 amino acid residues of the mature von Willebrand Factor (vWF)…”
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FVIII Inhibitor IgG Subclass and FVIII Polypeptide Specificity Determined by Immunoblotting by Carol, A. Fulcher, Sytske, de Graaf Mahoney, Theodore, S. Zimmerman

“…We used immunoblotting of purified factor VIII coagulant protein (FVIII) to localize FVIII inhibitor epitopes in 76 inhibitor plasmas to either the 92-kd FVIII…”
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Epitope Mapping of Human Factor VIII Inhibitor Antibodies by Deletion Analysis of Factor VIII Fragments Expressed in Escherichia coli by Scandella, Dorothea, Mahoney, Sytske DeGraaf, Mattingly, Mora, Roeder, David, Timmons, Lisa, Fulcher, Carol A.

“…Epitopes for antibodies that inhibit factor VIII procoagulant protein were analyzed by deletion mapping of factor VIII protein fragments expressed in…”
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Localization of Epitopes for Human Factor VIII Inhibitor Antibodies by Immunoblotting and Antibody Neutralization by Scandella, Dorothea, Mattingly, Mora, de Graaf, Sytske, Fulcher, Carol A.

“…Human factor VIII(FVIII) inhibitors are pathologic, circulating antibodies that inactivate FVIII. We have examined the location of epitopes on the FVIII…”
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Characterization of the Human Factor VIII Procoagulant Protein with a Heterologous Precipitating Antibody by Fulcher, Carol A., Zimmerman, Theodore S.

“…The human factor VIII procoagulant protein (VIIIC) was purified from the VIIIC-factor VIII-related antigen (VIIIRAg) complex in commercial factor VIII…”
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Proteolytic Inactivation of Human Factor VIII Procoagulant Protein by Activated Human Protein C and its Analogy With Factor V by Fulcher, Carol A., Gardiner, Joyce E., Griffin, John H., Zimmerman, Theodore S.

“…Purified human factor VIII procoagulant protein (VIII:C) was treated with purified human activated protein C (APC) and the loss of VIILC activity correlated…”
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Thrombin Proteolysis of Purified Factor VIII Procoagulant Protein: Correlation of Activation With Generation of a Specific Polypeptide by Fulcher, Carol A., Roberts, James R., Zimmerman, Theodore S.

“…Factor VIII procoagulant protein (VIII:C) purified from commercial factor VIII concentrate contained multiple polypeptides ranging in mol wt from 79,000 to…”
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Epitope mapping of human factor VIII inhibitor antibodies by site-directed mutagenesis of a factor VIII polypeptide by Ware, J, MacDonald, M J, Lo, M, de Graaf, S, Fulcher, C A

“…Previous epitope mapping studies of human factor VIII (FVIII) inhibitor antibodies with heavy chain specificity localized epitopes to the amino-terminal half…”
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Human factor VIII procoagulant protein: monoclonal antibodies define precursor-product relationships and functional epitopes by FULCHER, C. A, ROBERTS, J. R, HOLLAND, L. Z, ZIMMERMAN, T. S

“…The human Factor VIII procoagulant protein (VIII:C) purified from commercial Factor VIII concentrate consisted of a polypeptide doublet of 80,000 mol wt, a…”
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An Arginine to Cysteine Amino Acid Substitution at a Critical Thrombin Cleavage Site in a Dysfunctional Factor VIII Molecule by Shima, Midori, Ware, Jerry, Yoshioka, Akira, Fukui, Hiromu, Fulcher, Carol A.

“…We have analyzed the factor VIII (FVIII) protein and the nucleotide sequence around two thrombin cleavage sites, at arginine 372 in the FVIII heavy chain and…”
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An arginine to cysteine amino acid substitution at a critical thrombin cleavage site in a dysfunctional factor VIII molecule by Shima, M, Ware, J, Yoshioka, A, Fukui, H, Fulcher, CA

“…We have analyzed the factor VIII (FVIII) protein and the nucleotide sequence around two thrombin cleavage sites, at arginine 372 in the FVIII heavy chain and…”
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Immunoblot Analysis Shows Changes in Factor VIII Inhibitor Chain Specificity in Factor VIII Inhibitor Patients Over Time by Fulcher, Carol A., Lechner, Klaus, Mahoney, Sytske de G.

“…We have used immunoblotting of purified factor VIII (FVIII) to determine whether or not changes in FVIII chain specificity occur during the course of an…”
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Localization of the binding site for a factor VIII activity neutralizing antibody to amino acid residues Asp1663-Ser1669 by Shima, M, Fulcher, C A, de Graaf Mahoney, S, Houghten, R A, Zimmerman, T S

“…We have identified the Factor VIII amino acid sequence Asp-Tyr-Asp-Asp-Thr-Ile-Ser (1663-1669) as the binding site of a Factor VIII activity neutralizing…”
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Localization of Human Factor FVIII Inhibitor Epitopes to Two Polypeptide Fragments by Fulcher, Carol A., Sytske De Graaf Mahoney, Roberts, James R., Kasper, Carol K., Zimmerman, Theodore S.

“…Epitopes for 22 alloantibodies that inhibit factor VIII procoagulant protein (FVIII) from multitransfused individuals with severe hemophilia A and three…”
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An immunogenic region within residues Val1670-Glu1684 of the factor VIII light chain induces antibodies which inhibit binding of factor VIII to von Willebrand factor by Foster, P A, Fulcher, C A, Houghten, R A, Zimmerman, T S

“…We have identified a monoclonal anti-factor VIII (FVIII) antibody, C4, which inhibits the binding of purified human FVIII to purified human von Willebrand…”
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Synthetic Factor VIII Peptides With Amino Acid Sequences Contained Within the C2 Domain of Factor VIII Inhibit Factor VIII Binding to Phosphatidylserine by Foster, Paul A., Fulcher, Carol A., Houghten, Richard A., Zimmerman, Theodore S.

“…The effective activation of factor × by factor IXa requires the co-factor activity of activated factor VIII (FVIII). Factor Xa formation is also dependent on…”
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Enzyme-linked immunoassays for CRM positive hemophilia A using monoclonal antibodies with defined epitopes by Tanaka, I, Kasper, C K, Fulcher, C A

“…Sensitive, monoclonal antibody-based, enzyme-linked immunosorbent assays (ELISAs) for plasma factor VIII (FVIII) antigen have been developed. The assays used…”
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Factor VIII/von Willebrand factor by Zimmerman, T S, Ruggeri, Z M, Fulcher, C A

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