Search Results - "Fukuto, Jon M"

Reactive cysteine persulfides and S-polythiolation regulate oxidative stress and redox signaling by Ida, Tomoaki, Sawa, Tomohiro, Ihara, Hideshi, Tsuchiya, Yukihiro, Watanabe, Yasuo, Kumagai, Yoshito, Suematsu, Makoto, Motohashi, Hozumi, Fujii, Shigemoto, Matsunaga, Tetsuro, Yamamoto, Masayuki, Ono, Katsuhiko, Devarie-Baez, Nelmi O., Xian, Ming, Fukuto, Jon M., Akaike, Takaaki

“…Using methodology developed herein, it is found that reactive persulfides and polysulfides are formed endogenously from both small molecule species and…”
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Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics by Akaike, Takaaki, Ida, Tomoaki, Wei, Fan-Yan, Nishida, Motohiro, Kumagai, Yoshito, Alam, Md. Morshedul, Ihara, Hideshi, Sawa, Tomohiro, Matsunaga, Tetsuro, Kasamatsu, Shingo, Nishimura, Akiyuki, Morita, Masanobu, Tomizawa, Kazuhito, Nishimura, Akira, Watanabe, Satoshi, Inaba, Kenji, Shima, Hiroshi, Tanuma, Nobuhiro, Jung, Minkyung, Fujii, Shigemoto, Watanabe, Yasuo, Ohmuraya, Masaki, Nagy, Péter, Feelisch, Martin, Fukuto, Jon M., Motohashi, Hozumi

“…Cysteine hydropersulfide (CysSSH) occurs in abundant quantities in various organisms, yet little is known about its biosynthesis and physiological functions…”
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The Reactive Species Interactome: Evolutionary Emergence, Biological Significance, and Opportunities for Redox Metabolomics and Personalized Medicine by Cortese-Krott, Miriam M, Koning, Anne, Kuhnle, Gunter G C, Nagy, Peter, Bianco, Christopher L, Pasch, Andreas, Wink, David A, Fukuto, Jon M, Jackson, Alan A, van Goor, Harry, Olson, Kenneth R, Feelisch, Martin

“…Oxidative stress is thought to account for aberrant redox homeostasis and contribute to aging and disease. However, more often than not, administration of…”
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Biological hydropersulfides and related polysulfides – a new concept and perspective in redox biology by Fukuto, Jon M., Ignarro, Louis J., Nagy, Peter, Wink, David A., Kevil, Christopher G., Feelisch, Martin, Cortese‐Krott, Miriam M., Bianco, Christopher L., Kumagai, Yoshito, Hobbs, Adrian J., Lin, Joseph, Ida, Tomoaki, Akaike, Takaaki

“…The chemical biology of thiols (RSH, e.g., cysteine and cysteine‐containing proteins/peptides) has been a topic of extreme interest for many decades due to…”
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Carbon disulfide. Just toxic or also bioregulatory and/or therapeutic? by DeMartino, Anthony W, Zigler, David F, Fukuto, Jon M, Ford, Peter C

“…The overview presented here has the goal of examining whether carbon disulfide (CS ) may play a role as an endogenously generated bioregulator and/or has…”
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The antioxidant and oxidant properties of hydropersulfides (RSSH) and polysulfide species by Switzer, Christopher H., Fukuto, Jon M.

“…It has become apparent that hydrogen sulfide (H2S), hydropersulfides (RSSH) and other polysulfide species are all intimately linked biochemically. Indeed, at…”
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Chemical Biology of Hydropersulfides and Related Species: Possible Roles in Cellular Protection and Redox Signaling by Álvarez, Lucía, Bianco, Christopher L, Toscano, John P, Lin, Joseph, Akaike, Takaaki, Fukuto, Jon M

“…For >20 years, physiological signaling associated with the endogenous generation of hydrogen sulfide (H S) has been of significant interest. Despite its…”
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The chemical biology of the persulfide (RSSH)/perthiyl (RSS·) redox couple and possible role in biological redox signaling by Bianco, Christopher L., Chavez, Tyler A., Sosa, Victor, Saund, Simran, S., Nguyen, Q. Nhu N., Tantillo, Dean J., Ichimura, Andrew S., Toscano, John P., Fukuto, Jon M.

“…The recent finding that hydropersulfides (RSSH) are biologically prevalent in mammalian systems has prompted further investigation of their chemical properties…”
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The chemical biology of protein hydropersulfides: Studies of a possible protective function of biological hydropersulfide generation by Millikin, Robert, Bianco, Christopher L., White, Corey, Saund, Simran S., Henriquez, Stephanie, Sosa, Victor, Akaike, Takaaki, Kumagai, Yoshito, Soeda, Shuhei, Toscano, John P., Lin, Joseph, Fukuto, Jon M.

“…The recent discovery of significant hydropersulfide (RSSH) levels in mammalian tissues, fluids and cells has led to numerous questions regarding their possible…”
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Thiol chemistry in peroxidase catalysis and redox signaling by Bindoli, Alberto, Fukuto, Jon M, Forman, Henry Jay

“…The oxidation chemistry of thiols and disulfides of biologic relevance is described. The review focuses on the interaction and kinetics of hydrogen peroxide…”
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Persulfides: current knowledge and challenges in chemistry and chemical biology by Park, Chung-Min, Weerasinghe, Laksiri, Day, Jacob J, Fukuto, Jon M, Xian, Ming

“…Recent studies conducted in hydrogen sulfide (H2S) signaling have revealed potential importance of persulfides (RSSH) in redox biology. The inherent…”
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Signaling and stress: The redox landscape in NOS2 biology by Thomas, Douglas D., Heinecke, Julie L., Ridnour, Lisa A., Cheng, Robert Y., Kesarwala, Aparna H., Switzer, Christopher H., McVicar, Daniel W., Roberts, David D., Glynn, Sharon, Fukuto, Jon M., Wink, David A., Miranda, Katrina M.

“…Nitric oxide (NO) has a highly diverse range of biological functions from physiological signaling and maintenance of homeostasis to serving as an effector…”
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The chemistry of cell signaling by reactive oxygen and nitrogen species and 4-hydroxynonenal by Forman, Henry Jay, Fukuto, Jon M., Miller, Tom, Zhang, Hongqiao, Rinna, Alessandra, Levy, Smadar

“…During the past several years, major advances have been made in understanding how reactive oxygen species (ROS) and nitrogen species (RNS) participate in…”
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Examining the reaction of NO and H₂S and the possible cross-talk between the two signaling pathways by Bianco, Christopher L., Fukuto, Jon M.

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Polysulfide stabilization by tyrosine and hydroxyphenyl-containing derivatives that is important for a reactive sulfur metabolomics analysis by Hamid, Hisyam Abdul, Tanaka, Akira, Ida, Tomoaki, Nishimura, Akira, Matsunaga, Tetsuro, Fujii, Shigemoto, Morita, Masanobu, Sawa, Tomohiro, Fukuto, Jon M, Nagy, Péter, Tsutsumi, Ryouhei, Motohashi, Hozumi, Ihara, Hideshi, Akaike, Takaaki

“…The physiological importance of reactive sulfur species (RSS) such as cysteine hydropersulfide (CysSSH) has been increasingly recognized in recent years. We…”
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Cysteine hydropersulfide reduces lipid peroxidation and protects against myocardial ischaemia-reperfusion injury - Are endogenous persulfides mediators of ischaemic preconditioning? by Griffiths, Kayleigh, Ida, Tomoaki, Morita, Masanobu, Lamb, Reece J., Lee, Jordan J., Frenneaux, Michael P., Fukuto, Jon M., Akaike, Takaaki, Feelisch, Martin, Madhani, Melanie

“…Earlier studies revealed the presence of cysteine persulfide (CysSSH) and related polysulfide species in various mammalian tissues. CysSSH has both antioxidant…”
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The Uptake and Release of Polysulfur Cysteine Species by Cells: Physiological and Toxicological Implications by Lin, Joseph, Akiyama, Masahiro, Bica, Iris, Long, Faith T, Henderson, Catherine F, Goddu, Robert N, Suarez, Valeria, Baker, Blaine, Ida, Tomoaki, Shinkai, Yasuhiro, Nagy, Peter, Akaike, Takaaki, Fukuto, Jon M, Kumagai, Yoshito

“…Hydropersulfides and related polysulfides have recently become topics of significant interest due to their physiological prevalence and proposed biological…”
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Redox signaling: thiol chemistry defines which reactive oxygen and nitrogen species can act as second messengers by Forman, Henry Jay, Fukuto, Jon M, Torres, Martine

“…Except for the role of NO in the activation of guanylate cyclase, which is well established, the involvement of reactive oxygen species (ROS) and reactive…”
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The chemical biology of hydropersulfides (RSSH): Chemical stability, reactivity and redox roles by Saund, Simran S., Sosa, Victor, Henriquez, Stephanie, Nguyen, Q. Nhu N., Bianco, Christopher L., Soeda, Shuhei, Millikin, Robert, White, Corey, Le, Henry, Ono, Katsuhiko, Tantillo, Dean J., Kumagai, Yoshito, Akaike, Takaaki, Lin, Joseph, Fukuto, Jon M.

“…Recent reports indicate the ubiquitous prevalence of hydropersulfides (RSSH) in mammalian systems. The biological utility of these and related species is…”
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Free radical biology and medicine: it's a gas, man by Pryor, William A, Houk, Kendall N, Foote, Christopher S, Fukuto, Jon M, Ignarro, Louis J, Squadrito, Giuseppe L, Davies, Kelvin J A

“…We review gases that can affect oxidative stress and that themselves may be radicals. We discuss O(2) toxicity, invoking superoxide, hydrogen peroxide, and the…”
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