Search Results - "Fukusumi, Takahito"

HPV E2, E4, E5 drive alternative carcinogenic pathways in HPV positive cancers by Ren, Shuling, Gaykalova, Daria A., Guo, Theresa, Favorov, Alexander V., Fertig, Elana J., Tamayo, Pablo, Callejas-Valera, Juan Luis, Allevato, Mike, Gilardi, Mara, Santos, Jessica, Fukusumi, Takahito, Sakai, Akihiro, Ando, Mizuo, Sadat, Sayed, Liu, Chao, Xu, Guorong, Fisch, Kathleen M., Wang, Zhiyong, Molinolo, Alfredo A., Gutkind, J. Silvio, Ideker, Trey, Koch, Wayne M., Califano, Joseph A.

“…The dominant paradigm for HPV carcinogenesis includes integration into the host genome followed by expression of E6 and E7 (E6/E7). We explored an alternative…”
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The NOTCH4 - HEY1 Pathway Induces Epithelial-Mesenchymal Transition in Head and Neck Squamous Cell Carcinoma by Fukusumi, Takahito, Guo, Theresa W, Sakai, Akihiro, Ando, Mizuo, Ren, Shuling, Haft, Sunny, Liu, Chao, Amornphimoltham, Panomwat, Gutkind, J Silvio, Califano, Joseph A

“…Recently, several comprehensive genomic analyses demonstrated and mutations in head and neck squamous cell carcinoma (HNSCC) in approximately 20% of cases…”
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Chromatin dysregulation and DNA methylation at transcription start sites associated with transcriptional repression in cancers by Ando, Mizuo, Saito, Yuki, Xu, Guorong, Bui, Nam Q., Medetgul-Ernar, Kate, Pu, Minya, Fisch, Kathleen, Ren, Shuling, Sakai, Akihiro, Fukusumi, Takahito, Liu, Chao, Haft, Sunny, Pang, John, Mark, Adam, Gaykalova, Daria A., Guo, Theresa, Favorov, Alexander V., Yegnasubramanian, Srinivasan, Fertig, Elana J., Ha, Patrick, Tamayo, Pablo, Yamasoba, Tatsuya, Ideker, Trey, Messer, Karen, Califano, Joseph A.

“…Although promoter-associated CpG islands have been established as targets of DNA methylation changes in cancer, previous studies suggest that epigenetic…”
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Circulating tumor HPV DNA complements PET‐CT in guiding management after radiotherapy in HPV‐related squamous cell carcinoma of the head and neck by Tanaka, Hidenori, Takemoto, Norihiko, Horie, Masafumi, Takai, Erina, Fukusumi, Takahito, Suzuki, Motoyuki, Eguchi, Hirotaka, Komukai, Sho, Tatsumi, Mitsuaki, Isohashi, Fumiaki, Ogawa, Kazuhiko, Yachida, Shinichi, Inohara, Hidenori

“…Positron emission tomography and computed tomography (PET‐CT) is widely used to assess the response to radiotherapy. However, the ability of PET‐CT to predict…”
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Performance of oral HPV DNA, oral HPV mRNA and circulating tumor HPV DNA in the detection of HPV‐related oropharyngeal cancer and cancer of unknown primary by Tanaka, Hidenori, Suzuki, Motoyuki, Takemoto, Norihiko, Fukusumi, Takahito, Eguchi, Hirotaka, Takai, Erina, Kanai, Haruka, Tatsumi, Mitsuaki, Horie, Masafumi, Takenaka, Yukinori, Yachida, Shinichi, Inohara, Hidenori

“…A biomarker that is useful for the detection of human papillomavirus (HPV)‐related oropharyngeal cancer (OPC) and cancer of unknown primary (CUP) is…”
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Cannabinoids Promote Progression of HPV-Positive Head and Neck Squamous Cell Carcinoma via p38 MAPK Activation by Liu, Chao, Sadat, Sayed H, Ebisumoto, Koji, Sakai, Akihiro, Panuganti, Bharat A, Ren, Shuling, Goto, Yusuke, Haft, Sunny, Fukusumi, Takahito, Ando, Mizuo, Saito, Yuki, Guo, Theresa, Tamayo, Pablo, Yeerna, Huwate, Kim, William, Hubbard, Jacqueline, Sharabi, Andrew B, Gutkind, J Silvio, Califano, Joseph A

“…Human papillomavirus (HPV)-related head and neck squamous cell carcinoma (HNSCC) is associated with daily marijuana use and is also increasing in parallel with…”
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A novel splice variant of LOXL2 promotes progression of human papillomavirus–negative head and neck squamous cell carcinoma by Liu, Chao, Guo, Theresa, Sakai, Akihiro, Ren, Shuling, Fukusumi, Takahito, Ando, Mizuo, Sadat, Sayed, Saito, Yuki, Califano, Joseph A.

“…Background Head and neck squamous cell carcinoma (HNSCC) is one of the most frequently diagnosed cancers worldwide. LOXL2 demonstrates alternative splicing…”
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Association of circulating tumor HPV16DNA levels and quantitative PET parameters in patients with HPV-positive head and neck squamous cell carcinoma by Tatsumi, Mitsuaki, Tanaka, Hidenori, Takenaka, Yukinori, Suzuki, Motoyuki, Fukusumi, Takahito, Eguchi, Hirotaka, Watabe, Tadashi, Kato, Hiroki, Yachida, Shinichi, Inohara, Hidenori, Tomiyama, Noriyuki

“…Circulating tumor DNA (ctDNA), which circulates in the blood after being shed from cancer cells in the body, has recently gained attention as an excellent…”
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Characterization of Alternative Splicing Events in HPV-Negative Head and Neck Squamous Cell Carcinoma Identifies an Oncogenic DOCK5 Variant by Liu, Chao, Guo, Theresa, Xu, Guorong, Sakai, Akihiro, Ren, Shuling, Fukusumi, Takahito, Ando, Mizuo, Sadat, Sayed, Saito, Yuki, Khan, Zubair, Fisch, Kathleen M, Califano, Joseph

“…Head and neck squamous cell carcinoma (HNSCC) is one of the most common cancers worldwide, and alternative splicing is considered to play important roles in…”
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Mutation of chromatin regulators and focal hotspot alterations characterize human papillomavirus–positive oropharyngeal squamous cell carcinoma by Haft, Sunny, Ren, Shuling, Xu, Guorong, Mark, Adam, Fisch, Kathleen, Guo, Theresa W., Khan, Zubair, Pang, John, Ando, Mizuo, Liu, Chao, Sakai, Akihiro, Fukusumi, Takahito, Califano, Joseph A.

“…Background Human papillomavirus (HPV)–associated oropharyngeal cancer is a disease clinically and biologically distinct from smoking‐related head and neck…”
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Discovery and development of differentially methylated regions in human papillomavirus‐related oropharyngeal squamous cell carcinoma by Ren, Shuling, Gaykalova, Daria, Wang, Jennifer, Guo, Theresa, Danilova, Ludmila, Favorov, Alexander, Fertig, Elana, Bishop, Justin, Khan, Zubair, Flam, Emily, Wysocki, Piotr T., DeJong, Peter, Ando, Mizuo, Liu, Chao, Sakai, Akihiro, Fukusumi, Takahito, Haft, Sunny, Sadat, Sayed, Califano, Joseph A.

“…Human papillomavirus (HPV)‐related oropharyngeal squamous cell carcinoma (OPSCC) exhibits a different composition of epigenetic alterations. In this study, we…”
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Reciprocal activation of HEY1 and NOTCH4 under SOX2 control promotes EMT in head and neck squamous cell carcinoma by Fukusumi, Takahito, Guo, Theresa W, Ren, Shuling, Haft, Sunny, Liu, Chao, Sakai, Akihiro, Ando, Mizuo, Saito, Yuki, Sadat, Sayed, Califano, Joseph A

“…Several comprehensive studies have demonstrated that the NOTCH pathway is altered in a bimodal manner in head and neck squamous cell carcinoma (HNSCC). In a…”
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Adipose‐derived mesenchymal stem cells and regenerative medicine by Konno, Masamitsu, Hamabe, Atsushi, Hasegawa, Shinichiro, Ogawa, Hisataka, Fukusumi, Takahito, Nishikawa, Shimpei, Ohta, Katsuya, Kano, Yoshihiro, Ozaki, Miyuki, Noguchi, Yuko, Sakai, Daisuke, Kudoh, Toshihiro, Kawamoto, Koichi, Eguchi, Hidetoshi, Satoh, Taroh, Tanemura, Masahiro, Nagano, Hiroaki, Doki, Yuichiro, Mori, Masaki, Ishii, Hideshi

“…Adipose tissue‐derived mesenchymal stem cells (ADSCs) are multipotent and can differentiate into various cell types, including osteocytes, adipocytes, neural…”
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Radiation Therapy Alone for Human Papillomavirus-Related Squamous Cell Carcinoma of the Oropharynx: A Single-Arm, Phase 2 Study by Takemoto, Norihiko, Seo, Yuji, Nakahara, Susumu, Yoshioka, Yasuo, Teshima, Teruki, Fujii, Takashi, Isohashi, Fumiaki, Otani, Keisuke, Yoshii, Tadashi, Takenaka, Yukinori, Suzuki, Motoyuki, Fukusumi, Takahito, Hanamoto, Atsushi, Yasui, Toshimichi, Michiba, Takahiro, Yamamoto, Yoshifumi, Shimamoto, Shigetoshi, Tanaka, Hidenori, Tatsumi, Mitsuaki, Ogawa, Kazuhiko, Inohara, Hidenori

“…Human papillomavirus (HPV)-related squamous cell carcinoma of the oropharynx (OPSCC) is extremely radiosensitive. Radiation therapy plus high-dose cisplatin…”
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Prognostic significance of body mass index before treatment for head and neck cancer by Takenaka, Yukinori, Takemoto, Norihiko, Nakahara, Susumu, Yamamoto, Yoshifumi, Yasui, Toshimichi, Hanamoto, Atshushi, Fukusumi, Takahito, Michiba, Takahiro, Cho, Hironori, Yamamoto, Masashi, Inohara, Hidenori

“…ABSTRACT Background Patients with head and neck cancer frequently experience malnutrition. The purpose of this study was to examine the impact of nutritional…”
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Aberrant expression of CPSF1 promotes head and neck squamous cell carcinoma via regulating alternative splicing by Sakai, Akihiro, Ando, Mizuo, Fukusumi, Takahito, Ren, Shuling, Liu, Chao, Qualliotine, Jesse, Haft, Sunny, Sadat, Sayed, Saito, Yuki, Guo, Theresa W, Xu, Guorong, Sasik, Roman, Fisch, Kathleen M, Gutkind, J Silvio, Fertig, Elana J, Molinolo, Alfredo A, Califano, Joseph A

“…Alternative mRNA splicing increases protein diversity, and alternative splicing events (ASEs) drive oncogenesis in multiple tumor types. However, the driving…”
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Transaminase Activity Predicts Survival in Patients with Head and Neck Cancer by Takenaka, Yukinori, Takemoto, Norihiko, Yasui, Toshimichi, Yamamoto, Yoshifumi, Uno, Atsuhiko, Miyabe, Haruka, Ashida, Naoki, Shimizu, Kotaro, Nakahara, Susumu, Hanamoto, Atshushi, Fukusumi, Takahito, Michiba, Takahiro, Cho, Hironori, Yamamoto, Masashi, Inohara, Hidenori

“…Various serum biomarkers have been developed for predicting head and neck squamous cell carcinoma (HNSCC) prognosis. However, none of them have been proven to…”
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Publisher Correction: Chromatin dysregulation and DNA methylation at transcription start sites associated with transcriptional repression in cancers by Ando, Mizuo, Saito, Yuki, Xu, Guorong, Bui, Nam Q., Medetgul-Ernar, Kate, Pu, Minya, Fisch, Kathleen, Ren, Shuling, Sakai, Akihiro, Fukusumi, Takahito, Liu, Chao, Haft, Sunny, Pang, John, Mark, Adam, Gaykalova, Daria A., Guo, Theresa, Favorov, Alexander V., Yegnasubramanian, Srinivasan, Fertig, Elana J., Ha, Patrick, Tamayo, Pablo, Yamasoba, Tatsuya, Ideker, Trey, Messer, Karen, Califano, Joseph A.

“…The original version of this Article contained an error in the author affiliations. Trey Ideker was incorrectly associated with ‘Department of Medicine…”
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Clinical, genomic and immune microenvironmental determinants of nivolumab response in head and neck squamous cell carcinoma by Tsujikawa, Takahiro, Ohno, Kazuchika, Morita, Kei-Ichi, Saburi, Sumiyo, Mitsuda, Junichi, Yoshimura, Kanako, Kimura, Alisa, Morimoto, Hiroki, Ogi, Hiroshi, Shibata, Saya, Akashi, Takumi, Kurata, Morito, Imoto, Issei, Shimizu, Yasushi, Kano, Satoshi, Watanabe, Akihito, Yamazaki, Tomoko, Asada, Yukinori, Hayashi, Ryuichi, Saito, Yuki, Ozawa, Hiroyuki, Tsukahara, Kiyoaki, Oridate, Nobuhiko, Sano, Daisuke, Horii, Arata, Ueki, Yushi, Maruo, Takashi, Mukoyama, Nobuaki, Hanai, Nobuhiro, Fukusumi, Takahito, Iwai, Hiroshi, Fujisawa, Takuo, Fujii, Takashi, Nibu, Ken-Ichi, Iwae, Shigemichi, Ueda, Tsutomu, Chikuie, Nobuyuki, Yasumatsu, Ryuji, Matsuo, Mioko, Umeno, Hirohito, Ono, Takeharu, Masuda, Muneyuki, Toh, Satoshi, Itoh, Kyoko, Hirano, Shigeru, Asakage, Takahiro

“…In view of improving biomarkers predicting the efficacy of immunotherapy for head and neck squamous cell carcinoma (R/M HNSCC), this multicenter retrospective…”
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Rational genomic optimization of DNA detection for human papillomavirus type 16 in head and neck squamous cell carcinoma by Saito, Yuki, Favorov, Alexander V., Forman, Michael, Ren, Shuling, Sakai, Akihiro, Fukusumi, Takahito, Liu, Chao, Sadat, Sayed, Ando, Mizuo, Xu, Guorong, Khan, Zubair, Pang, John, Valsamakis, Alex, Fisch, Kathleen M., Califano, Joseph A.

“…Background We aimed to use genomic data for optimizing polymerase chain reaction (PCR) primer/probe sets for detection of human papillomavirus (HPV)‐16 in body…”
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