Search Results - "Fukushima, Hiroto"

Incomplete erasure of histone marks during epigenetic reprogramming in medaka early development by Fukushima, Hiroto S, Takeda, Hiroyuki, Nakamura, Ryohei

“…Epigenetic modifications undergo drastic erasure and reestablishment after fertilization. This reprogramming is required for proper embryonic development and…”
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Cell cycle length governs heterochromatin reprogramming during early development in non-mammalian vertebrates by Fukushima, Hiroto S, Ikeda, Takafumi, Ikeda, Shinra, Takeda, Hiroyuki

“…Heterochromatin marks such as H3K9me3 undergo global erasure and re-establishment after fertilization, and the proper reprogramming of H3K9me3 is essential for…”
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Unlinking the methylome pattern from nucleotide sequence, revealed by large-scale in vivo genome engineering and methylome editing in medaka fish by Cheung, Napo K M, Nakamura, Ryohei, Uno, Ayako, Kumagai, Masahiko, Fukushima, Hiroto S, Morishita, Shinichi, Takeda, Hiroyuki

“…The heavily methylated vertebrate genomes are punctuated by stretches of poorly methylated DNA sequences that usually mark gene regulatory regions. It is known…”
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TAS-119, a novel selective Aurora A and TRK inhibitor, exhibits antitumor efficacy in preclinical models with deregulated activation of the Myc, β-Catenin, and TRK pathways by Miura, Akihiro, Sootome, Hiroshi, Fujita, Naoya, Suzuki, Takamasa, Fukushima, Hiroto, Mizuarai, Shinji, Masuko, Norio, Ito, Kimihiro, Hashimoto, Akihiro, Uto, Yoshihiro, Sugimoto, Tetsuya, Takahashi, Hidekazu, Mitsuya, Morihiro, Hirai, Hiroshi

“…Summary Aurora kinase A, a mitotic kinase that is overexpressed in various cancers, is a promising cancer drug target. Here, we performed preclinical…”
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Malic enzyme 1 is a potential marker of combined hepatocellular cholangiocarcinoma, subtype with stem‐cell features, intermediate‐cell type by Mihara, Yutaro, Akiba, Jun, Ogasawara, Sachiko, Kondo, Reiichiro, Fukushima, Hiroto, Itadani, Hiraku, Obara, Hitoshi, Kakuma, Tatsuyuki, Kusano, Hironori, Naito, Yoshiki, Okuda, Koji, Nakashima, Osamu, Yano, Hirohisa

“…Aim Combined hepatocellular cholangiocarcinoma, subtype with stem‐cell features, intermediate‐cell subtype (INT) shows various histological appearances and…”
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Targeted in vivo epigenome editing of H3K27me3 by Fukushima, Hiroto S, Takeda, Hiroyuki, Nakamura, Ryohei

“…Epigenetic modifications have a central role in transcriptional regulation. While several studies using next-generation sequencing have revealed genome-wide…”
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In Vivo Effects of Cyclosporin A and Ketoconazole on the Pharmacokinetics of Representative Substrates for P-Glycoprotein and Cytochrome P450 (CYP) 3A in Rats by Kageyama, Michiharu, Namiki, Hitomi, Fukushima, Hiroto, Ito, Yukako, Shibata, Nobuhito, Takada, Kanji

“…In this study, the in vivo effects of cyclosporin A (CsA) and ketoconazole (KCZ), which are used as inhibitors of P-glycoprotein (Pgp) and cytochrome P450…”
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Effect of Chronic Administration of Ritonavir on Function of Cytochrome P450 3A and P-Glycoprotein in Rats by Kageyama, Michiharu, Namiki, Hitomi, Fukushima, Hiroto, Terasaka, Shuichi, Togawa, Tatsuya, Tanaka, Akina, Ito, Yukako, Shibata, Nobuhito, Takada, Kanji

“…Ritonavir (RTV) is well known as an inhibitor of many drugs that are metabolized by cytochrome P450 (CYP) 3A or fluxed via P-glycoprotein (Pgp), although it is…”
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Alteration of dihydropyrimidine dehydrogenase expression by IFN-α affects the antiproliferative effects of 5-fluorouracil in human hepatocellular carcinoma cells by Oie, Shinji, Ono, Mayumi, Fukushima, Hiroto, Hosoi, Fumihito, Yano, Hirohisa, Maruyama, Yuichiro, Kojiro, Masamichi, Terada, Tadafumi, Hirano, Kazuyuki, Kuwano, Michihiko, Yamada, Yuji

“…Dihydropyrimidine dehydrogenase (DPD) is the rate-limiting enzyme in the catabolism of 5-fluorouracil (5-FU) and its activity is closely associated with…”
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Abstract P020: Schlafen 11 (SLFN11) as a predictive biomarker of the response to TAS1553, a novel small molecule ribonucleotide reductase subunit interaction inhibitor by Fukushima, Hiroto, Ueno, Hiroyuki, Hoshino, Takuya, Yano, Wakako, Itadani, Hiraku, Terasaka, Miki, Tsukioka, Sayaka, Suzuki, Takamasa, Hara, Shoki, Ogino, Yoshio, Chong, Khoon Tee, Suzuki, Tatsuya, Otsu, Yoshihiro, Ito, Satoshi, Tanaka, Nozomu, Miyahara, Seiji

“…Abstract Background: Ribonucleotide reductase (RNR) plays a crucial role in dNTP biosynthesis, which is required for DNA synthesis and repair, and is thought…”
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3'-ethynylcytidine, an RNA polymerase inhibitor, combined with cisplatin exhibits a potent synergistic growth-inhibitory effect via Vaults dysfunction by Fukushima, Hiroto, Abe, Tetsuya, Sakamoto, Kazuki, Tsujimoto, Hiroaki, Mizuarai, Shinji, Oie, Shinji

“…We previously reported that 3'-ethynylcytidine (ECyd, TAS-106), an RNA polymerases inhibitor, enhances the anti-tumor efficacy of platinum in several tumor…”
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ARHGEF15 overexpression worsens the prognosis in patients with pancreatic ductal adenocarcinoma through enhancing the motility and proliferative activity of the cancer cells by Fukushima, Hiroto, Yasumoto, Makiko, Ogasawara, Sachiko, Akiba, Jun, Kitasato, Yuhei, Nakayama, Masamichi, Naito, Yoshiki, Ishida, Yusuke, Okabe, Yoshinobu, Yasunaga, Masafumi, Horiuchi, Hiroyuki, Sakamoto, Etsuko, Itadani, Hiraku, Mizuarai, Shinji, Oie, Shinji, Yano, Hirohisa

“…Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive neoplastic diseases, associated with a remarkably poor prognosis. However, the molecular…”
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Abstract 514: ARHGEF15 is associated with a poor prognosis in patients with pancreatic ductal adenocarcinoma through a mechanism involving the enhancement of cellular motility and proliferation by Fukushima, Hiroto, Yasumoto, Makiko, Ogasawara, Sachiko, Akiba, Jun, Kitasato, Yuhei, Naito, Yoshiki, Nakayama, Masamichi, Okabe, Yoshinobu, Yasunaga, Masafumi, Horiuchi, Hiroyuki, Sakamoto, Etsuko, Itadani, Hiraku, Mizuarai, Shinji, Oie, Shinji, Yano, Hirohisa

“…Abstract Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive cancers and is associated with an extremely poor prognosis, since it is…”
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Abstract 2757: TAS-106, a newly synthesized RNA polymerase inhibitor, combined with cisplatin exhibits potent synergistic growth-inhibitory effect via Vaults dysfunction by Fukushima, Hiroto, Abe, Tetsuya, Tsujimoto, Akihiro, Kawabata, Rumi, Sakamoto, Kazuki, Oie, Shinji

“…Abstract TAS-106, 3′-C-ethynylcytidine, is a novel nucleoside analog that inhibits RNA polymerases I, II and III, and has been reported to exert potent…”
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Abstract C178: TAS-117, a highly potent and selective non-ATP competitive inhibitor of AKT, demonstrates a toxicity profile with manageable hyperglycemia in rats by Moriyama, Kenji, Yamaguchi, Masahiro, Sugimoto, Shigeo, Matsumura, Hirofumi, Ninomiya, Fumiko, Besshi, Kazuhiko, Morita, Fumio, Hayashi, Taiji, Fujita, Ryouto, Fukushima, Hiroto, Shimomura, Toshiyasu, Yonekura, Kazuhiko, Utsugi, Teruhiro

“…Abstract Background: TAS-117 is a small molecule which inhibits the PI3K-AKT-mTOR signaling pathway, a critical regulator of cell survival, by stimulating cell…”
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Targeted in vivo epigenome editing in medaka fish by Fukushima, Hiroto, Takeda, Hiroyuki, Nakamura, Ryohei

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CPAA study on carbon, boron and oxygen in LEC-GaAs by ITOH, Y, KADOTA, Y, NOZAKI, T, FUKUSHIMA, H, TAKEDA, K

“…Carbon, boron and oxygen in liquid-encapsulated Czochralski(LEC) semi-insulating GaAs crystals grown in three different ambiences (Ar, Ar+1% O 2 , and Ar+1%…”
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Simultaneous charged particle activation analysis of carbon and boron in gallium arsenide by NOZAKI, T, ITOH, Y, OHKUBO, Y, KIMURA, T, FUKUSHIMA, H

“…A simple method has been developed for simultaneous determination of carbon and boron in GaAs by deuteron activation analysis. The detection limit is 2×10 14…”
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Decontamination factors for other radionuclides in the determination of radiostrontium by Kimura, T, Muroi, T, Fukushima, H, Nishiyama, M

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Context dependency of facial expressions in communucations by Fukushima, Hiroto, Tanev, Ivan, Shimohara, Katsunori

“…The face expressions are considered to be a significant part of the very important nonverbal information, needed to understand the other party's feelings in…”
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