Search Results - "Fukumoto, Takeshi"

Global case fatality rate from COVID‐19 has decreased by 96.8% during 2.5 years of the pandemic by Horita, Nobuyuki, Fukumoto, Takeshi

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NAD+ metabolism governs the proinflammatory senescence-associated secretome by Nacarelli, Timothy, Lau, Lena, Fukumoto, Takeshi, Zundell, Joseph, Fatkhutdinov, Nail, Wu, Shuai, Aird, Katherine M., Iwasaki, Osamu, Kossenkov, Andrew V., Schultz, David, Noma, Ken-ichi, Baur, Joseph A., Schug, Zachary, Tang, Hsin-Yao, Speicher, David W., David, Gregory, Zhang, Rugang

“…Cellular senescence is a stable growth arrest that is implicated in tissue ageing and cancer. Senescent cells are characterized by an upregulation of…”
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Selective targeting of different populations of myeloid-derived suppressor cells by histone deacetylase inhibitors by Hashimoto, Ayumi, Fukumoto, Takeshi, Zhang, Rugang, Gabrilovich, Dmitry

“…Myeloid-derived suppressor cells (MDSCs) are widely implicated in negative regulation of immune responses in cancer. Inhibition of class I histone deacetylases…”
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Topoisomerase 1 cleavage complex enables pattern recognition and inflammation during senescence by Zhao, Bo, Liu, Pingyu, Fukumoto, Takeshi, Nacarelli, Timothy, Fatkhutdinov, Nail, Wu, Shuai, Lin, Jianhuang, Aird, Katherine M., Tang, Hsin-Yao, Liu, Qin, Speicher, David W., Zhang, Rugang

“…Cyclic cGMP-AMP synthase (cGAS) is a pattern recognition cytosolic DNA sensor that is essential for cellular senescence. cGAS promotes inflammatory…”
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Targeting the IRE1α/XBP1s pathway suppresses CARM1-expressing ovarian cancer by Lin, Jianhuang, Liu, Heng, Fukumoto, Takeshi, Zundell, Joseph, Yan, Qingqing, Tang, Chih-Hang Anthony, Wu, Shuai, Zhou, Wei, Guo, Dajiang, Karakashev, Sergey, Hu, Chih-Chi Andrew, Sarma, Kavitha, Kossenkov, Andrew V., Zhang, Rugang

“…CARM1 is often overexpressed in human cancers including in ovarian cancer. However, therapeutic approaches based on CARM1 expression remain to be an unmet…”
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EZH2 Inhibition Sensitizes CARM1-High, Homologous Recombination Proficient Ovarian Cancers to PARP Inhibition by Karakashev, Sergey, Fukumoto, Takeshi, Zhao, Bo, Lin, Jianhuang, Wu, Shuai, Fatkhutdinov, Nail, Park, Pyoung-Hwa, Semenova, Galina, Jean, Stephanie, Cadungog, Mark G., Borowsky, Mark E., Kossenkov, Andrew V., Liu, Qin, Zhang, Rugang

“…In response to DNA double-strand breaks, MAD2L2-containing shieldin complex plays a critical role in the choice between homologous recombination (HR) and…”
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Therapeutic strategies targeting cellular senescence for cancer and other diseases by Wang, Xuebing, Fukumoto, Takeshi, Noma, Ken-ichi

“…Abstract Cellular senescence occurs in response to endogenous or exogenous stresses and is characterized by stable cell cycle arrest, alterations in nuclear…”
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Skin tests and immunohistochemical analyses of erythroderma caused by sodium bisulfite by Otsuka, Haruhiko, Fukumoto, Takeshi, Sasaki, Yoshihito, Adachi, Atsuko

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Effectiveness of tacrolimus ointment for dupilumab‐resistant facial erythema by Fukumoto, Takeshi, Nishigori, Chikako

“…Some patients treated with dupilumab for atopic dermatitis (AD) develop resistance on their face, despite achieving good response on other body parts. The…”
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Immune checkpoint inhibitors for metastatic uveal melanoma: a meta-analysis by Yamada, Kayoko, Takeuchi, Masaki, Fukumoto, Takeshi, Suzuki, Minako, Kato, Ai, Mizuki, Yuki, Yamada, Norihiro, Kaneko, Takeshi, Mizuki, Nobuhisa, Horita, Nobuyuki

“…Several studies have evaluated immune checkpoint inhibitors (ICIs) for metastatic uveal melanoma; however, the efficacy of ICIs in the previous studies varied…”
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Recurrent palmoplantar pustulosis at the site of insertion of therapeutic titanium by Fukumoto, Takeshi, Horita, Nobuyuki, Yoshioka, Ai

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The best dosage of nivolumab plus ipilimumab combination for melanoma brain metastases by Fukumoto, Takeshi, Horita, Nobuyuki

“…•Nivolumab 1 mg/kg plus ipilimumab 3 mg/kg every 3 weeks for four doses (N1I3) provided durable survival for patients with active melanoma brain metastases…”
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Treatment of henna-induced Riehl’s melanosis with a 755-nm picosecond alexandrite laser by Iwayama, Takanori, Oka, Masahiro, Fukumoto, Takeshi

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Sensitization of ovarian tumor to immune checkpoint blockade by boosting senescence-associated secretory phenotype by Hao, Xue, Zhao, Bo, Zhou, Wei, Liu, Heng, Fukumoto, Takeshi, Gabrilovich, Dmitry, Zhang, Rugang

“…Therapy-induced senescence-associated secretory phenotype (SASP) correlates with overcoming resistance to immune checkpoint blockade (ICB). Intrinsic…”
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ARID1A promotes genomic stability through protecting telomere cohesion by Zhao, Bo, Lin, Jianhuang, Rong, Lijie, Wu, Shuai, Deng, Zhong, Fatkhutdinov, Nail, Zundell, Joseph, Fukumoto, Takeshi, Liu, Qin, Kossenkov, Andrew, Jean, Stephanie, Cadungog, Mark G., Borowsky, Mark E., Drapkin, Ronny, Lieberman, Paul M., Abate-Shen, Cory T., Zhang, Rugang

“…ARID1A inactivation causes mitotic defects. Paradoxically, cancers with high ARID1A mutation rates typically lack copy number alterations (CNAs). Here, we show…”
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SWI/SNF catalytic subunits’ switch drives resistance to EZH2 inhibitors in ARID1A-mutated cells by Wu, Shuai, Fatkhutdinov, Nail, Fukumoto, Takeshi, Bitler, Benjamin G., Park, Pyoung Hwa, Kossenkov, Andrew V., Trizzino, Marco, Tang, Hsin-Yao, Zhang, Lin, Gardini, Alessandro, Speicher, David W., Zhang, Rugang

“…Inactivation of the subunits of SWI/SNF complex such as ARID1A is synthetically lethal with inhibition of EZH2 activity. However, mechanisms of de novo…”
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Replication-related genes are upregulated in XP-A cells after UV-C irradiation by Takeuchi, Seiji, Matsuda, Toshiro, Tsujimoto, Mariko, Fukumoto, Takeshi, Ono, Ryusuke, Nishigori, Chikako

“…•Replication-related genes were upregulated in xeroderma pigmentosum-A cells by UV exposure.•XPA protein is considered to play a role in regulating replication…”
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m6A-independent genome-wide METTL3 and METTL14 redistribution drives the senescence-associated secretory phenotype by Liu, Pingyu, Li, Fuming, Lin, Jianhuang, Fukumoto, Takeshi, Nacarelli, Timothy, Hao, Xue, Kossenkov, Andrew V., Simon, M. Celeste, Zhang, Rugang

“…Methyltransferase-like 3 (METTL3) and 14 (METTL14) are core subunits of the methyltransferase complex that catalyses messenger RNA N 6 -methyladenosine (m 6 A)…”
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Confluent and reticulated papillomatosis with eruptions on the trunk and extremities by Fukumoto, Takeshi, Oka, Masahiro

“…Dear Editor, Confluent and reticulated papillomatosis (CRP) is a rare skin disorder in young individuals. It is clinically characterized by slightly…”
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Single or dual immune checkpoint inhibitor as adjuvant therapy in advanced melanoma by Fukumoto, Takeshi, Horita, Nobuyuki

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