Introduction of pharmacogenetic screening for the human leucocyte antigen (HLA) B5701 variant in Polish HIV‐infected patients

Introduction of pharmacogenetic screening for the human leucocyte antigen (HLA) B5701 variant in Polish HIV‐infected patients

Objective Prospective pharmacogenetic screening for the human leucocyte antigen (HLA) B*5701 allele can significantly reduce the number of cases of abacavir‐related hypersensitivity among HIV‐infected patients treated with this drug. The aim of this study was to establish the frequency of the HLA B*...

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Bibliographic Details
Published in:HIV medicine Vol. 11; no. 5; pp. 345 - 348
Main Authors: Parczewski, M, Leszczyszyn‐Pynka, M, Wnuk, A, Urbañska, A, Fuksiñska, K, Bander, D, Boroñ‐Kaczmarska, A
Format: Journal Article
Language:English
Published: Oxford, UK Blackwell Publishing Ltd 01-05-2010
Subjects:
abacavir hypersensitivity
Adult
Alleles
antiretroviral treatment
Dideoxynucleosides - adverse effects
Drug Hypersensitivity - genetics
Drugs
Feasibility Studies
Female
Gene Frequency
Genetic Testing
Genotype
Histocompatibility antigen HLA
HIV Infections - drug therapy
HIV Infections - genetics
HLA B57
HLA-B Antigens - analysis
HLA-B Antigens - genetics
Human immunodeficiency virus
Humans
Hypersensitivity
Leukocytes
Male
Middle Aged
Mutation
Pharmacogenetics
Poland
Polymerase Chain Reaction - methods
Predictive Value of Tests
Primers
Reverse Transcriptase Inhibitors - adverse effects
Skin Tests
Poland
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Summary:Objective Prospective pharmacogenetic screening for the human leucocyte antigen (HLA) B*5701 allele can significantly reduce the number of cases of abacavir‐related hypersensitivity among HIV‐infected patients treated with this drug. The aim of this study was to establish the frequency of the HLA B*5701 variant in HIV‐infected Poles. Methods The sequence‐specific primer (SSP) test was used to assess the feasibility of the introduction of such testing in clinical practice. For this purpose, 234 randomly selected HIV‐positive patients were screened using a low‐resolution SSP assay, with HLA B*5701‐positive results confirmed using a high‐resolution test. Results and Conclusions The HLA B*5701 variant was found in 11 of 234 subjects (4.7%). Testing with the selected method proved quick and reliable.
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ISSN:1464-2662
1468-1293
DOI:10.1111/j.1468-1293.2009.00787.x