Search Results - "Fukaya, Tomohiro"

Clec4A4 is a regulatory receptor for dendritic cells that impairs inflammation and T-cell immunity by Uto, Tomofumi, Fukaya, Tomohiro, Takagi, Hideaki, Arimura, Keiichi, Nakamura, Takeshi, Kojima, Naoya, Malissen, Bernard, Sato, Katsuaki

“…Dendritic cells (DCs) comprise several subsets that are critically involved in the initiation and regulation of immunity. Clec4A4/DC immunoreceptor 2 (DCIR2)…”
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Plasmacytoid dendritic cells orchestrate TLR7-mediated innate and adaptive immunity for the initiation of autoimmune inflammation by Takagi, Hideaki, Arimura, Keiichi, Uto, Tomofumi, Fukaya, Tomohiro, Nakamura, Takeshi, Choijookhuu, Narantsog, Hishikawa, Yoshitaka, Sato, Katsuaki

“…Endosomal toll-like receptor (TLR)-mediated detection of viral nucleic acids (NAs) and production of type I interferon (IFN-I) are key elements of antiviral…”
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Critical role of plasmacytoid dendritic cells in induction of oral tolerance by Uto, Tomofumi, Takagi, Hideaki, Fukaya, Tomohiro, Nasu, Junta, Fukui, Takehito, Miyanaga, Noriaki, Arimura, Keiichi, Nakamura, Takeshi, Choijookhuu, Narantsog, Hishikawa, Yoshitaka, Sato, Katsuaki

“…Exposure to dietary constituents through the mucosal surface of the gastrointestinal tract generates oral tolerance that prevents deleterious T cell–mediated…”
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Crucial role of dendritic cells in the generation of anti-tumor T-cell responses and immunogenic tumor microenvironment to suppress tumor development by Tominaga, Moe, Uto, Tomofumi, Fukaya, Tomohiro, Mitoma, Shuya, Riethmacher, Dieter, Umekita, Kunihiko, Yamashita, Yoshihiro, Sato, Katsuaki

“…Dendritic cells (DCs) are known as unique professional antigen (Ag)-presenting cells (APCs) to prime naïve T cells for the initiation of adaptive immunity…”
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Pivotal role of the carbohydrate recognition domain in self-interaction of CLEC4A to elicit the ITIM-mediated inhibitory function in murine conventional dendritic cells in vitro by Nasu, Junta, Uto, Tomofumi, Fukaya, Tomohiro, Takagi, Hideaki, Fukui, Takehito, Miyanaga, Noriaki, Nishikawa, Yotaro, Yamasaki, Sho, Yamashita, Yoshihiro, Sato, Katsuaki

“…Abstract C-type lectin receptors (CLRs), pattern recognition receptors (PRRs) with a characteristic carbohydrate recognition domain (CRD) in the extracellular…”
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A study on machining of binder-less polycrystalline diamond by femtosecond pulsed laser for fabrication of micro milling tools by Ogawa, Yoshinori, Ota, Michiharu, Nakamoto, Kazuo, Fukaya, Tomohiro, Russell, Marc, Zohdi, Tarek I., Yamazaki, Kazuo, Aoyama, Hideki

“…Since binder-less polycrystalline diamond (BLPCD) has no macro cleavage planes and highest hardness, it is desirable material for micro milling tools. However,…”
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Spatiotemporal expression of HMGB2 regulates cell proliferation and hepatocyte size during liver regeneration by Yano, Koichi, Choijookhuu, Narantsog, Ikenoue, Makoto, Fidya, Fukaya, Tomohiro, Sato, Katsuaki, Lee, Deokcheol, Taniguchi, Noboru, Chosa, Etsuo, Nanashima, Atsushi, Hishikawa, Yoshitaka

“…Liver regeneration is an extraordinarily complex process involving a variety of factors; however, the role of chromatin protein in hepatocyte proliferation is…”
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Gut dysbiosis promotes the breakdown of oral tolerance mediated through dysfunction of mucosal dendritic cells by Fukaya, Tomohiro, Uto, Tomofumi, Mitoma, Shuya, Takagi, Hideaki, Nishikawa, Yotaro, Tominaga, Moe, Choijookhuu, Narantsog, Hishikawa, Yoshitaka, Sato, Katsuaki

“…While dysbiosis in the gut is implicated in the impaired induction of oral tolerance generated in mesenteric lymph nodes (MesLNs), how dysbiosis affects this…”
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Pivotal role of CD103 in the development of psoriasiform dermatitis by Fukui, Takehito, Fukaya, Tomohiro, Uto, Tomofumi, Takagi, Hideaki, Nasu, Junta, Miyanaga, Noriaki, Nishikawa, Yotaro, Koseki, Haruhiko, Choijookhuu, Narantsog, Hishikawa, Yoshitaka, Yamashita, Yoshihiro, Sato, Katsuaki

“…The integrin αE known as CD103 binds integrin β7 to form the complete heterodimeric integrin molecule αEβ7. CD103 is mainly expressed by lymphocytes within…”
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Pivotal Role of IL-22 Binding Protein in the Epithelial Autoregulation of Interleukin-22 Signaling in the Control of Skin Inflammation by Fukaya, Tomohiro, Fukui, Takehito, Uto, Tomofumi, Takagi, Hideaki, Nasu, Junta, Miyanaga, Noriaki, Arimura, Keiichi, Nakamura, Takeshi, Koseki, Haruhiko, Choijookhuu, Narantsog, Hishikawa, Yoshitaka, Sato, Katsuaki

“…Disruption of skin homeostasis can lead to inflammatory cutaneous diseases resulting from the dysregulated interplay between epithelial keratinocytes and…”
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Coronae of product spaces and the coarse Baum–Connes conjecture by Fukaya, Tomohiro, Oguni, Shin-ichi

“…We study the coarse Baum–Connes conjecture for product spaces and product groups. We show that a product of CAT(0) groups, polycyclic groups and relatively…”
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Low dose CP-690,550 (tofacitinib), a pan-JAK inhibitor, accelerates the onset of experimental autoimmune encephalomyelitis by potentiating Th17 differentiation by Yoshida, Hideyuki, Kimura, Akihiro, Fukaya, Tomohiro, Sekiya, Takashi, Morita, Rimpei, Shichita, Takashi, Inoue, Hiromasa, Yoshimura, Akihiko

“…► Low dose CP-690,550 (tofacitinib) inhibited CIA but accelerated EAE models. ► Low dose CP-690550 inhibited Th1 and Th2 but enhanced Th17 development. ► Low…”
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Conditional ablation of CD205⁺ conventional dendritic cells impacts the regulation of T-cell immunity and homeostasis in vivo by Fukaya, Tomohiro, Murakami, Ryuichi, Takagi, Hideaki, Sato, Kaori, Sato, Yumiko, Otsuka, Haruna, Ohno, Michiko, Hijikata, Atsushi, Ohara, Osamu, Hikida, Masaki, Malissen, Bernard, Sato, Katsuaki

“…Dendritic cells (DCs) are composed of multiple subsets that play a dual role in inducing immunity and tolerance. However, it is unclear how CD205 ⁺…”
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Congenital Deficiency of Conventional Dendritic Cells Promotes the Development of Atopic Dermatitis-Like Inflammation by Nishikawa, Yotaro, Fukaya, Tomohiro, Fukui, Takehito, Uto, Tomofumi, Takagi, Hideaki, Nasu, Junta, Miyanaga, Noriaki, Riethmacher, Dieter, Choijookhuu, Narantsog, Hishikawa, Yoshitaka, Amano, Masahiro, Sato, Katsuaki

“…Atopic dermatitis (AD) is a common pruritic inflammatory skin disease characterized by impaired epidermal barrier function and dysregulation of Thelper-2 (T…”
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Suppression of SOCS3 in macrophages prevents cancer metastasis by modifying macrophage phase and MCP2/CCL8 induction by Hiwatashi, Kiyokazu, Tamiya, Taiga, Hasegawa, Eiichi, Fukaya, Tomohiro, Hashimoto, Masayuki, Kakoi, Kyosuke, Kashiwagi, Ikko, Kimura, Akihiro, Inoue, Naoko, Morita, Rimpei, Yasukawa, Hideo, Yoshimura, Akihiko

“…Abstract Inflammation has been demonstrated to play important roles in tumorigenesis, tumor progression, and metastasis. STAT3 has been shown to be frequently…”
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Essential role of submandibular lymph node dendritic cells in protective sublingual immunotherapy against murine allergy by Miyanaga, Noriaki, Takagi, Hideaki, Uto, Tomofumi, Fukaya, Tomohiro, Nasu, Junta, Fukui, Takehito, Nishikawa, Yotaro, Sparwasser, Tim, Choijookhuu, Narantsog, Hishikawa, Yoshitaka, Nakamura, Takeshi, Tono, Tetsuya, Sato, Katsuaki

“…While sublingual immunotherapy (SLIT) is known as an allergen-specific treatment for type-1 allergies, how it controls allergic pathogenesis remains unclear…”
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Aryl hydrocarbon receptor plays protective roles in ConA-induced hepatic injury by both suppressing IFN-γ expression and inducing IL-22 by Abe, Hiromi, Kimura, Akihiro, Tsuruta, Sanae, Fukaya, Tomohiro, Sakaguchi, Ryota, Morita, Rimpei, Sekiya, Takashi, Shichita, Takashi, Chayama, Kazuaki, Fujii-Kuriyama, Yoshiaki, Yoshimura, Akihiko

“…The aryl hydrocarbon receptor (AhR), a ligand-activated nuclear transcription factor, is known to mediate the toxic and carcinogenic effects of various…”
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Regulatory dendritic cells protect against allergic airway inflammation in a murine asthmatic model by Fujita, Shigeharu, MD, Yamashita, Naomi, MD, PhD, Ishii, Yasuyuki, PhD, Sato, Yumiko, Sato, Kaori, Eizumi, Kawori, Fukaya, Tomohiro, BVSc, Nozawa, Risa, Takamoto, Yukiko, Yamashita, Naohide, MD, PhD, Taniguchi, Masaru, MD, PhD, Sato, Katsuaki, PhD

“…Background Dendritic cells (DCs) are crucial for the induction of immunity and tolerance. Despite an improved understanding of the DC-mediated control of TH…”
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Naturally occurring regulatory dendritic cells regulate murine cutaneous chronic graft-versus-host disease by Sato, Kaori, Eizumi, Kawori, Fukaya, Tomohiro, Fujita, Shigeharu, Sato, Yumiko, Takagi, Hideaki, Yamamoto, Mai, Yamashita, Naohide, Hijikata, Atsushi, Kitamura, Hiroshi, Ohara, Osamu, Yamasaki, Sho, Saito, Takashi, Sato, Katsuaki

“…Chronic graft-versus-host disease (cGVHD) is a limiting factor in allogeneic hematopoietic stem cell transplantation (alloHSCT) for the treatment of leukemia…”
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Selective depletion of basophils ameliorates immunoglobulin E-mediated anaphylaxis by Nakamura, Takeshi, Fukaya, Tomohiro, Uto, Tomofumi, Takagi, Hideaki, Arimura, Keiichi, Tono, Tetsuya, Sato, Katsuaki

“…Basophils, which are the rarest granulocytes, play crucial roles in protective immunity against parasites and development of allergic disorders. Although…”
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