Search Results - "Fukaya, Hiroaki"

Diffusion of Al and Al-Substituting Elements in Ni3Al at Elevated Temperatures by Moniruzzaman, Md, Fukaya, Hiroaki, Murata, Yoshinori, Tanaka, Katsushi, Inui, Haruyuki

“…Diffusion of Ti, V, Nb, Mo and Ta in Ni3Al phase was investigated at different temperatures using Ni–Al–X (X = Ti, V, Nb, Mo, Ta) pseudo-binary diffusion…”
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Effect of Cathepsin K Inhibitors on Bone Resorption by Teno, Naoki, Masuya, Keiichi, Ehara, Takeru, Kosaka, Takatoshi, Miyake, Takahiro, Irie, Osamu, Hitomi, Yuko, Matsuura, Naoko, Umemura, Ichiro, Iwasaki, Genji, Fukaya, Hiroaki, Toriyama, Kazuhiro, Uchiyama, Noriko, Nonomura, Kazuhiko, Sugiyama, Ikuo, Kometani, Motohiko

“…On the basis of the pyrrolopyrimidine core structure that was previously discovered, cathepsin K inhibitors having a spiro amine at the P3 have been explored…”
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Synthesis and structure–activity relationship of RXR antagonists based on the diazepinylbenzoic acid structure by Sakaki, Junichi, Konishi, Kazuhide, Kishida, Masashi, Gunji, Hiroki, Kanazawa, Takanori, Uchiyama, Hidefumi, Fukaya, Hiroaki, Mitani, Hironobu, Kimura, Masaaki

“…Synthesis and structure–activity relationship of RXR antagonists employing a diazepinylbenzoic acid scaffold are described. The sulfonamide derivatives were…”
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Synthesis and structure–activity relationship of novel RXR antagonists: Orally active anti-diabetic and anti-obesity agents by Sakaki, Junichi, Kishida, Masashi, Konishi, Kazuhide, Gunji, Hiroki, Toyao, Atsushi, Matsumoto, Yuki, Kanazawa, Takanori, Uchiyama, Hidefumi, Fukaya, Hiroaki, Mitani, Hironobu, Arai, Yoshie, Kimura, Masaaki

“…A series of diazepinylbenzoic acid derivatives were synthesized and tested in the inhibition assayof the transactivation of RXR. Oral treatment of cyano…”
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Development of tolerance and supersensitivity to phencyclidine in rats after repeated administration of phencyclidine by Nabeshima, T, Fukaya, H, Yamaguchi, K, Ishikawa, K, Furukawa, H, Kameyama, T

“…In rats treated with phencyclidine (PCP) repeatedly (PCP 10 mg/kg per day for 14 days), the back-pedalling, head-weaving and turning induced by PCP were…”
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Discovery of Orally Bioavailable Cathepsin S Inhibitors for the Reversal of Neuropathic Pain by Irie, Osamu, Kosaka, Takatoshi, Ehara, Takeru, Yokokawa, Fumiaki, Kanazawa, Takanori, Hirao, Hajime, Iwasaki, Astuko, Sakaki, Junichi, Teno, Naoki, Hitomi, Yuko, Iwasaki, Genji, Fukaya, Hiroaki, Nonomura, Kazuhiko, Tanabe, Keiko, Koizumi, Shinichi, Uchiyama, Noriko, Bevan, Stuart J, Malcangio, Marzia, Gentry, Clive, Fox, Alyson J, Yaqoob, Mohammed, Culshaw, Andrew J, Hallett, Allan

“…Cathepsin S inhibitors are well-known to be an attractive target as immunological therapeutic agents. Recently, our gene expression analysis identified that…”
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Discovery of selective and nonpeptidic cathepsin S inhibitors by Irie, Osamu, Ehara, Takeru, Iwasaki, Atsuko, Yokokawa, Fumiaki, Sakaki, Junichi, Hirao, Hajime, Kanazawa, Takanori, Teno, Naoki, Horiuchi, Miyuki, Umemura, Ichiro, Gunji, Hiroki, Masuya, Keiichi, Hitomi, Yuko, Iwasaki, Genji, Nonomura, Kazuhiko, Tanabe, Keiko, Fukaya, Hiroaki, Kosaka, Takatoshi, Snell, Christopher R., Hallett, Allan

“…Nonpeptidic, selective, and potent cathepsin S inhibitors were derived from an in-house pyrrolopyrimidine cathepsin K inhibitor by modification of the P2 and…”
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THE ANTAGONIST EFFECTS OF COMPOUNDS DERIVED FROM KHELLACTONE ON PLATELET-ACTIVATING FACTOR by Takeuchi, Naoki, Kasama, Toshio, Mayuzumi, Kiyoshi, Tamaru, Kenji, Fukaya, Hiroaki, Ohno, Takayuki, Tobinaga, Seisho

“…Crude coumarin constituents of Peucedanum praeruptorum Duun. including praeruptorin A (=Pd-Ia)(2) and B (=Pd-II)(11) had an antagonistic effect on a specific…”
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Partially inhibitory effects of SDZ MAR 327 on substantia nigra dopamine neurons in rat midbrain slices by Seno, Naoki, Iimura, Akiko, Fukaya, Hiroaki, Demura, Nobutaka, Ohara, Tatsuo

“…SDZ MAR 327 (MAR), a novel ergoline derivative, has high affinity for central D_2 receptors and additionally for α_1 , 5-HT_1A , and 5-HT_2 receptors…”
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Different profile of SDZ ENA 713 from other acetylcholinesterase inhibitors to improve cholinergic deficit in basal forebrain-lesioned rats by Ohara, Tatsuo, Tanaka, Ken-ichi, Fukaya, Hiroaki, Akahane, Noriko, Demura, Nobutaka, Seno, Naoki

“…We previously reported that SDZ ENA 713 (ENA) improved both spatial learning disability and cholinergic dysfunction in basal forebrain (BF)-lesioned rats. The…”
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Effects of SDZ MAR 327 on the 5-HT receptor subtypes mediated behavioral responses in rat by Fukaya, Hiroaki, Ohhara, Tatsuo, Demura, Nobutaka, Tanaka, Ken-ichi, Seno, Naoki

“…SDZ MAR 327(MAR) is a novel ergoline derivative which exhibits both partial dopamine(DA)_2 agonistic action and DA_1 blockade. Furthermore, MAR has relatively…”
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Effects or SDZ ENA-713 on choline acetyltransferase activity and muscarinic acetylcholine receptor binding in the brains of learning impaired rats by Tanaka, Ken-ichi, Oh-hara, Tatsuo, Fukaya, Hiroaki, Demura, Nobutaka, liniura, Akiko, Seno, Naoki

“…It has been shown that SDZ ENA-713 (ENA), a centrally acting acetylcholinesterase inhibitor, improved learning disability of behavioral tasks in animal models…”
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Effects of SDZ ENA 713 on spatial memory impairment in basal forebrain-lesioned rats by Oh-hara, Tatsuo, Tanaka, Ken-ich, Fukaya, Hiroaki, Demura, Nobutaka, Yasuda, Hideko, Seno, Naoki

“…SDZ ENA 713 (ENA), a new phenylcarbamate derivative, is a centrally acting acetylcholinesterase inhibitor. In order to evaluate the effect of the compound on…”
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SDZ ENA 713 facilitates central cholinergic function and ameliorates spatial memory impairment in rats by Ohara, Tatsuo, Tanaka, Ken-ichi, Fukaya, Hiroaki, Demura, Nobutaka, Iimura, Akiko, Seno, Naoki

“…We have clarified the effects of SDZ ENA 713 (ENA), a new phenyl-carbamate derivative, on the spatial learning impairment and neurochemical indices of central…”
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Ameliorating Effects of SDZ ENA 713 on Age-Associated Decreases in Learning Performance and Brain Choline Acetyltransferase Activity in Rats by Ohara, Tatsuo, Fukaya, Hiroaki, Tanaka, Ken-ichi, Seno, Naoki

“…In the present study, we have investigated the effects of SDZ ENA 713 on spatial learning deficits in aged rats. Using the same animals, the effect of SDZ ENA…”
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EFFECTS OF CHROMAN DERIVATIVES ON PLATELET AGGREGATION INDUCED BY SOME AGGREGATING AGENTS IN RABBITS by Aida, Yoko, Kasama, Toshio, Fukaya, Hiroaki, Takeuchi, Naoki, Sugiyama, Kumiko, Tobinaga, Seisho

“…SUMMARY 1. We synthesized 10 chroman derivatives (CD‐1 to CD‐10) derived from khellactone, including praeruptorin A and praeruptorin B and examined the effects…”
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Potentiation of phencyclidine-induced stereotyped behaviors in rats by thiorphan and bestatin by Hiramatsu, M, Nabeshima, T, Fukaya, H, Furukawa, H, Kameyama, T

“…We investigated the effects of thiorphan, a specific inhibitor of enkephalinase A and bestatin, a specific inhibitor of aminopeptidase, on the stereotyped…”
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P-464 - Partially inhibitory effects of SDZ MAR 327 on substantia nigra dopamine neurons in rat midbrain slices by Seno, Naoki, Iimura, Akiko, Fukaya, Hiroaki, Demura, Nobutaka, Ohara, Tatsuo

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Biphenyls, a new class of compound that inhibits plateletactivating factors by TAKEYA, Tetsuya, TAKEUCHI, Naoki, KASAMA, Toshio, MAYUZUMI, Kiyoshi, FUKAYA, Hiroaki, TOBINAGA, Seisho

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BIPHENYLS, A NEW CLASS OF COMPOUND THAT INHIBITS PLATELET-ACTIVATING FACTORS by TAKEYA, Tetsuya, TAKEUCHI, Naoki, KASAMA, Toshio, MAYUZUMI, Kiyoshi, FUKAYA, Hiroaki, TOBINAGA, Seisho

“…Honokiol (1), a constituent of Magnoliae cortex, and related synthetic biphenyls inhibited the platelet aggregation induced by a few aggrgating agents. In…”
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