Search Results - "Fujiwara, Hironori"

Post-weaning social isolation of mice: A putative animal model of developmental disorders by Matsumoto, Kinzo, Fujiwara, Hironori, Araki, Ryota, Yabe, Takeshi

“…Post-weaning social isolation of laboratory animals is known to induce many behavioural and neurochemical abnormalities, which resemble neuropsychiatric…”
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Alterations in the Levels of Amyloid-β, Phospholipid Hydroperoxide, and Plasmalogen in the Blood of Patients with Alzheimer's Disease: Possible Interactions between Amyloid-β and These Lipids by Yamashita, Shinji, Kiko, Takehiro, Fujiwara, Hironori, Hashimoto, Michio, Nakagawa, Kiyotaka, Kinoshita, Mikio, Furukawa, Katsutoshi, Arai, Hiroyuki, Miyazawa, Teruo

“…Aside from accumulation of amyloid-β (Aβ) peptide in the brain, Alzheimer's disease (AD) has been reported as being associated with peroxidation of major…”
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Effects of Puerarin on the Ovariectomy-Induced Depressive-Like Behavior in ICR Mice and Its Possible Mechanism of Action by Tantipongpiradet, Ariyawan, Monthakantirat, Orawan, Vipatpakpaiboon, Onchuma, Khampukdee, Charinya, Umehara, Kaoru, Noguchi, Hiroshi, Fujiwara, Hironori, Matsumoto, Kinzo, Sekeroglu, Nazim, Kijjoa, Anake, Chulikhit, Yaowared

“…Daily treatment of ovariectomized (OVX) ICR mice with puerarin, a glycosyl isoflavone isolated from the root bark of var. , and 17β-estradiol attenuated…”
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Protective effects of Bacopa monnieri on ischemia-induced cognitive deficits in mice: The possible contribution of bacopaside I and underlying mechanism by Le, Xoan Thi, Nguyet Pham, Hang Thi, Van Nguyen, Tai, Minh Nguyen, Khoi, Tanaka, Ken, Fujiwara, Hironori, Matsumoto, Kinzo

“…Bacopa monnieri (L.) Wettst. (BM) is a medicinal plant which has been not only used as a traditional medicine to improve intelligence and memory but also taken…”
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Bacopa monnieri (L.) Ameliorates Cognitive Deficits Caused in a Trimethyltin-Induced Neurotoxicity Model Mice by Pham, Hang Thi Nguyet, Phan, Sinh Viet, Tran, Hong Nguyen, Phi, Xuyen Thi, Le, Xoan Thi, Nguyen, Khoi Minh, Fujiwara, Hironori, Yoneyama, Masanori, Ogita, Kiyokazu, Yamaguchi, Taro, Matsumoto, Kinzo

“…We previously demonstrated that Bacopa monnier (L.) WETTST. extract (BME) ameliorated cognitive dysfunction in animal models of dementia by enhancing synaptic…”
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Kami-shoyo-san ameliorates sociability deficits in ovariectomized mice, a putative female model of autism spectrum disorder, via facilitating dopamine D1 and GABAA receptor functions by Guo, Qingyun, Ebihara, Ken, Fujiwara, Hironori, Toume, Kazufumi, Awale, Suresh, Araki, Ryota, Yabe, Takeshi, Dong, Erbo, Matsumoto, Kinzo

“…Kami-shoyo-san (KSS) is a Kampo formula used clinically for menopause-related symptoms in Japan. However, the effect of KSS on autism spectrum disorder (ASD),…”
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Kampo Formulations, Chotosan, and Yokukansan, for Dementia Therapy: Existing Clinical and Preclinical Evidence by Matsumoto, Kinzo, Zhao, Qi, Niu, Yimin, Fujiwara, Hironori, Tanaka, Ken, Sasaki-Hamada, Sachie, Oka, Jun-Ichiro

“…Cognitive deficits and behavioral and psychological symptoms of dementia (BPSD) are typical features of patients with dementia such as Alzheimer’s disease…”
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Antidepressant-like effect of Butea superba in mice exposed to chronic mild stress and its possible mechanism of action by Mizuki, Daishu, Matsumoto, Kinzo, Tanaka, Ken, Thi Le, Xoan, Fujiwara, Hironori, Ishikawa, Tsutomu, Higuchi, Yoshihiro

“…Butea superba (BS) is a Thai medicinal plant that has been used as a folk medicine to improve physical and mental conditions and to prevent impaired sexual…”
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Social Isolation Stress-Induced Fear Memory Deficit is Mediated by Down-Regulated Neuro-Signaling System and Egr-1 Expression in the Brain by Okada, Ryo, Matsumoto, Kinzo, Tsushima, Ryohei, Fujiwara, Hironori, Tsuneyama, Koichi

“…We previously reported that social isolation (SI) rearing of rodents not only elicits a variety of behavioral abnormalities including attention deficit…”
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Extraction of nobiletin from Citrus Unshiu peels by supercritical fluid and its CRE-mediated transcriptional activity by Oba, Chisato, Ota, Masaki, Nomura, Koichiro, Fujiwara, Hironori, Takito, Jiro, Sato, Yoshiyuki, Ohizumi, Yasushi, Inomata, Hiroshi

“…Polymethoxyflavone (PMF) is one of bioactive compounds in Citrus Unshiu and included mainly in the peels rather than the fruits, seeds and leaves…”
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Kamiuntanto increases prefrontal extracellular serotonin levels and ameliorates depression-like behaviors in mice by Hiraki, Yosuke, Araki, Ryota, Fujiwara, Hironori, Ago, Yukio, Tanaka, Tatsunori, Toume, Kazufumi, Matsumoto, Kinzo, Yabe, Takeshi

“…Kamiuntanto (KUT; Jia Wei Wen Dan Tang in Pinyin) is a traditional Japanese Kampo medicine that is used to treat psychological dysfunction. However, the…”
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Kihito prevents corticosterone-induced brain dysfunctions in mice by Araki, Ryota, Tachioka, Hayato, Kita, Ayami, Fujiwara, Hironori, Toume, Kazufumi, Matsumoto, Kinzo, Yabe, Takeshi

“…Kihito (KIT; Gui Pi Tang) is a traditional herbal medicine that is used for treatment of neuropsychiatric disorders such as depression, anxiety, neurosis and…”
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Butea superba–Induced Amelioration of Cognitive and Emotional Deficits in Olfactory Bulbectomized Mice and Putative Mechanisms Underlying Its Actions by Mizuki, Daishu, Qi, Zhao, Tanaka, Ken, Fujiwara, Hironori, Ishikawa, Tsutomu, Higuchi, Yoshihiro, Matsumoto, Kinzo

“…This study investigated the effects of alcoholic extract of Butea superba (BS) on cognitive deficits and depression-related behavior using olfactory…”
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A randomized, observer-blind, controlled trial of the traditional Chinese medicine Yi-Gan San for improvement of behavioral and psychological symptoms and activities of daily living in dementia patients by Iwasaki, Koh, Satoh-Nakagawa, Takuma, Maruyama, Masahiro, Monma, Yasutake, Nemoto, Miyako, Tomita, Naoki, Tanji, Haruko, Fujiwara, Hironori, Seki, Takashi, Fujii, Masahiko, Arai, Hiroyuki, Sasaki, Hidetada

“…This randomized, observer-blind, controlled trial examined the efficacy and safety of the traditional Chinese herbal medicine Yi-Gan San (YGS, Yokukan-San in…”
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Polygalae radix extract ameliorates behavioral and neuromorphological abnormalities in chronic corticosterone‐treated mice by Araki, Ryota, Fujiwara, Hironori, Matsumoto, Kinzo, Toume, Kazufumi, Yabe, Takeshi

“…ABSTRACT Aim Polygalae radix is a traditional herbal medicine used for treatment of anxiety or amnesia in several East Asian cultures. In this study, the…”
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Orengedokuto and san'oshashinto improve memory deficits by inhibiting aging-dependent activation of glycogen synthase kinase-3β by Fujiwara, Hironori, Yoshida, Jun, Dibwe, Dya Fita, Awale, Suresh, Hoshino, Haruka, Kohama, Hiroshi, Arai, Hiroyuki, Kudo, Yukitsuka, Matsumoto, Kinzo

“…Background and aim: The aging-dependent activation of glycogen synthase kinase-3β (GSK-3β) has been suggested to be important in the onset of dementia. To…”
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Bacopa monnieri (L.) Ameliorates Cognitive Deficits Caused in a Trimethyltin-Induced Neurotoxicity Model Mice by Hang Thi Nguyet Phama, Sinh Viet Phanb, Hong Nguyen Trana, Xuyen Thi Phia, Xoan Thi Lea, Khoi Minh Nguyena, Hironori Fujiwarac, Masanori Yoneyamad, Kiyokazu Ogitad, Taro Yamaguchid, Kinzo Matsumotoc

“…We previously demonstrated that Bacopa monnier (L.) WETTST. extract (BME) ameliorated cognitive dysfunction in animal models of dementia by enhancing synaptic…”
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Characteristics of nobiletin-mediated alteration of gene expression in cultured cell lines by Nemoto, Kiyomitsu, Ikeda, Ayaka, Yoshida, Chiaki, Kimura, Junko, Mori, Junki, Fujiwara, Hironori, Yokosuka, Akihito, Mimaki, Yoshihiro, Ohizumi, Yasushi, Degawa, Masakuni

“…► Nobiletin-mediated alterations of gene expression were examined with DNA microarrays. ► Three organ-derived cell lines were treated with 100μM nobiletin for…”
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Nobiletin, a flavone from Citrus depressa, induces gene expression and increases the protein level and activity of neprilysin in SK-N-SH cells by Fujiwara, Hironori, Kimura, Junko, Sakamoto, Masahiro, Yokosuka, Akihito, Mimaki, Yoshihiro, Murata, Kiyoshi, Yamaguchi, Kikuji, Ohizumi, Yasushi

“…Neprilysin (NEP) is one of the candidate amyloid β protein (Aβ) degrading enzymes affecting brain Aβ clearance. This enzyme declines in the brain with age,…”
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Sansoninto, a traditional herbal medicine, ameliorates behavioral abnormalities and down-regulation of early growth response-1 expression in mice exposed to social isolation stress by Fujiwara, Hironori, Tsushima, Ryohei, Okada, Ryo, Awale, Suresh, Araki, Ryota, Yabe, Takeshi, Matsumoto, Kinzo

“…Social isolation (SI) mice exhibit behavioral abnormalities such as impairments of sociability- and attention-like behaviors, offering an animal model of…”
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