Search Results - "Fujimura, Masatake"

Fasudil, a ROCK inhibitor, prevents neuropathic pain in Minamata disease model rats by Fujimura, Masatake

“…Methylmercury (MeHg), an environmental toxicant, is known to cause sensory impairment by inducing neurodegeneration of sensory nervous systems. However, in…”
Get full text

Gabapentin improves neuropathic pain in Minamata disease model rats by Fujimura, Masatake

“…Methylmercury (MeHg), the causative agent of Minamata disease, damages the cranial nervous system and causes specific sensory disturbances, especially…”
Get full text

Cellular Conditions Responsible for Methylmercury-Mediated Neurotoxicity by Fujimura, Masatake, Usuki, Fusako

“…Methylmercury (MeHg) is a widely known environmental pollutant that causes severe neurotoxicity. MeHg-induced neurotoxicity depends on various cellular…”
Get full text

Preliminary evaluation of the mechanism underlying vulnerability/resistance to methylmercury toxicity by comparative gene expression profiling of rat primary cultured cerebrocortical and hippocampal neurons by Fujimura, Masatake, Unoki, Takamitsu

“…Methylmercury (MeHg), an environmentally toxic substance, causes site-specific neuronal cell death; while MeHg exposure causes death in cerebrocortical…”
Get full text

Site-specific neural hyperactivity via the activation of MAPK and PKA/CREB pathways triggers neuronal degeneration in methylmercury-intoxicated mice by Fujimura, Masatake, Usuki, Fusako

“…•MeHg induced neural hyperactivity and neuronal degeneration in cerebral cortex.•Upregulation of neural activity preceded neuronal degeneration in cerebral…”
Get full text

Methylmercury induces hyperalgesia/allodynia through spinal cord dorsal horn neuronal activation and subsequent somatosensory cortical circuit formation in rats by Fujimura, Masatake, Usuki, Fusako, Nakamura, Atsushi

“…Methylmercury (MeHg) is known to cause serious neurological deficits in humans. In this study, we investigated the occurrence of MeHg-mediated neuropathic pain…”
Get full text

Pregnant rats exposed to low-level methylmercury exhibit cerebellar synaptic and neuritic remodeling during the perinatal period by Fujimura, Masatake, Usuki, Fusako

“…Methylmercury (MeHg) is a potent neurotoxic chemical, and gestational exposure to MeHg is known to cause developmental impairments in fetuses. Although it is…”
Get full text

Development of a sensor to detect methylmercury toxicity by Sumioka, Akio, Usuki, Fusako, Fujimura, Masatake

“…Methylmercury (MeHg) is a well-known neurotoxicant that induces various cellular functions depending on cellular- and developmental-specific vulnerabilities…”
Get full text

Dietary Fructooligosaccharides Reduce Mercury Levels in the Brain of Mice Exposed to Methylmercury by Nagano, Masaaki, Fujimura, Masatake, Tada, Yuya, Seko, Yoshiyuki

“…Methylmercury (MeHg) exposure during pregnancy is a concern because of its potential health risks to fetuses. Intestinal microbiota has important roles in the…”
Get full text

Environmental stresses suppress nonsense-mediated mRNA decay (NMD) and affect cells by stabilizing NMD-targeted gene expression by Usuki, Fusako, Yamashita, Akio, Fujimura, Masatake

“…Nonsense-mediated mRNA decay (NMD) is a cellular mechanism that eliminates mRNAs that harbor premature translation termination codons (PTCs). Here, we…”
Get full text

Methylmercury-Mediated Oxidative Stress and Activation of the Cellular Protective System by Fujimura, Masatake, Usuki, Fusako

“…Methylmercury (MeHg) is a well-known neurotoxicant that causes severe intoxication in humans. In Japan, it is referred to as Minamata disease, which involves…”
Get full text

Methylmercury causes neuronal cell death through the suppression of the TrkA pathway: In vitro and in vivo effects of TrkA pathway activators by Fujimura, Masatake, Usuki, Fusako

“…Methylmercury (MeHg) is an environmental toxin which induces cell death specific for the nervous systems. Here we show that MeHg causes neuronal cell death…”
Get full text

Fasudil, a Rho-Associated Coiled Coil-Forming Protein Kinase Inhibitor, Recovers Methylmercury-Induced Axonal Degeneration by Changing Microglial Phenotype in Rats by Fujimura, Masatake, Usuki, Fusako, Nakamura, Atsushi

“…Abstract Methylmercury (MeHg) is an environmental neurotoxicant that induces neuropathological changes. In this study, we established chronic MeHg-intoxicated…”
Get full text

Decreased plasma thiol antioxidant capacity precedes neurological signs in a rat methylmercury intoxication model by Fujimura, Masatake, Usuki, Fusako, Unoki, Takamitsu

“…The main target organ for MeHg is the nervous system, and its neurological dysfunction remains irreversible. Therefore, predictive biomarkers associated with…”
Get full text

Spatio-temporal distribution of reactive sulfur species during methylmercury exposure in the rat brain by Unoki, Takamitsu, Akiyama, Masahiro, Shinkai, Yasuhiro, Kumagai, Yoshito, Fujimura, Masatake

“…Brain susceptibility to methylmercury (MeHg) is developmentally and regionally specific in both humans and rodents, but the mechanism is not well clarified…”
Get full text

The selective GSK3 inhibitor, SAR502250, displays neuroprotective activity and attenuates behavioral impairments in models of neuropsychiatric symptoms of Alzheimer’s disease in rodents by Griebel, Guy, Stemmelin, Jeanne, Lopez-Grancha, Mati, Boulay, Denis, Boquet, Gerald, Slowinski, Franck, Pichat, Philippe, Beeské, Sandra, Tanaka, Shinji, Mori, Akiko, Fujimura, Masatake, Eguchi, Junichi

“…Glycogen synthase kinase 3 (GSK3) has been identified as a promising target for the treatment of Alzheimer’s disease (AD), where abnormal activation of this…”
Get full text

DNA methyltransferase- and histone deacetylase-mediated epigenetic alterations induced by low-level methylmercury exposure disrupt neuronal development by Go, Suzuna, Kurita, Hisaka, Hatano, Manami, Matsumoto, Kana, Nogawa, Hina, Fujimura, Masatake, Inden, Masatoshi, Hozumi, Isao

“…Methylmercury (MeHg) is a chemical substance that causes adverse effects on fetal development. However, the molecular mechanisms by which environmental MeHg…”
Get full text

Endoplasmic reticulum stress preconditioning modifies intracellular mercury content by upregulating membrane transporters by Usuki, Fusako, Fujimura, Masatake, Yamashita, Akio

“…Endoplasmic reticulum (ER) stress preconditioning protects cells against methylmercury (MeHg) cytotoxicity by inducing integrated stress responses such as…”
Get full text

Decreased plasma thiol antioxidant barrier and selenoproteins as potential biomarkers for ongoing methylmercury intoxication and an individual protective capacity by Usuki, Fusako, Fujimura, Masatake

“…Manifestation of methylmercury (MeHg) toxicity depends on individual susceptibility to MeHg, as well as MeHg burden level. Therefore, biomarkers that reflect…”
Get full text

Methylmercury Causes Blood-Brain Barrier Damage in Rats via Upregulation of Vascular Endothelial Growth Factor Expression by Takahashi, Tetsuya, Fujimura, Masatake, Koyama, Misaki, Kanazawa, Masato, Usuki, Fusako, Nishizawa, Masatoyo, Shimohata, Takayoshi

“…Clinical manifestations of methylmercury (MeHg) intoxication include cerebellar ataxia, concentric constriction of visual fields, and sensory and auditory…”
Get full text