Search Results - "Fujimura, Chizu"

The IL-1 promoter-driven luciferase reporter cell line THP-G1b can efficiently predict skin-sensitising chemicals by Terui, Hitoshi, Kimura, Yutaka, Fujimura, Chizu, Aiba, Setsuya

“…IL-1 functions as an essential pro-inflammatory mediator for the sensitisation of allergic contact dermatitis (ACD). However, studies conducted to date have…”
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The modified IL-8 Luc assay, an in vitro skin sensitisation test, can significantly improve the false-negative judgment of lipophilic sensitizers with logKow values > 3.5 by Kimura, Yutaka, Fujimura, Chizu, Aiba, Setsuya

“…False-negative judgment due to poor chemical solubility is a problem with in vitro skin sensitisation tests. Water-insoluble chemicals are typically dissolved…”
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Switching of Photocatalytic Tyrosine/Histidine Labeling and Application to Photocatalytic Proximity Labeling by Nakane, Keita, Nagasawa, Haruto, Fujimura, Chizu, Koyanagi, Eri, Tomoshige, Shusuke, Ishikawa, Minoru, Sato, Shinichi

“…Weak and transient protein interactions are involved in dynamic biological responses and are an important research subject; however, methods to elucidate such…”
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Optimization of the IL-2 Luc assay for immunosuppressive drugs: a novel in vitro immunotoxicity test with high sensitivity and predictivity by Kimura, Yutaka, Terui, Hitoshi, Fujimura, Chizu, Amagai, Ryo, Takahashi, Toshiya, Aiba, Setsuya

“…We have reported that the IL-2 Luc assay can detect the effects of chemicals on IL-2 promoter activity by using a dual reporter cell line, 2H4 cells that…”
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Functionalization of Human Serum Albumin by Tyrosine Click by Obara, Satsuki, Nakane, Keita, Fujimura, Chizu, Tomoshige, Shusuke, Ishikawa, Minoru, Sato, Shinichi

“…Human serum albumin (HSA) is a promising drug delivery carrier. Although covalent modification of Cys34 is a well-established method, it is desirable to…”
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Optimization of the IL-8 Luc assay as an in vitro test for skin sensitization by Kimura, Yutaka, Fujimura, Chizu, Ito, Yumiko, Takahashi, Toshiya, Nakajima, Yoshihiro, Ohmiya, Yoshihiro, Aiba, Setsuya

“…•We created another data set of 122 chemicals of the IL-8 Luc assay.•We analyzed the reason for poor performance of the original protocol.•The solubilizing…”
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Profiling the immunotoxicity of chemicals based on in vitro evaluation by a combination of the Multi-ImmunoTox assay and the IL-8 Luc assay by Kimura, Yutaka, Fujimura, Chizu, Ito, Yumiko, Takahashi, Toshiya, Terui, Hitoshi, Aiba, Setsuya

“…We established a luciferase reporter assay system, the Multi-ImmunoTox Assay (MITA), which can evaluate the effects of chemicals on the promoter activities of…”
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Evaluation of the Multi-ImmunoTox Assay composed of 3 human cytokine reporter cells by examining immunological effects of drugs by Kimura, Yutaka, Fujimura, Chizu, Ito, Yumiko, Takahashi, Toshiya, Aiba, Setsuya

“…•We established a luciferase reporter assay system, the Multi-ImmunoTox Assay (MITA).•MITA can evaluate the effects of chemicals on IL-2, IFN-γ, IL-8, and…”
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The performance of an in vitro skin sensitisation test, IL-8 Luc assay (OECD442E), and the integrated approach with direct peptide reactive assay (DPRA) by Kimura, Yutaka, Watanabe, Mika, Suzuki, Noriyuki, Iwaki, Tomoko, Yamakage, Kohji, Saito, Koichi, Nakajima, Yoshihiro, Fujimura, Chizu, Ohmiya, Yoshihiro, Omori, Takashi, Kojima, Hajime, Aiba, Setsuya

“…In all current in vitro skin sensitisation assays, DMSO is used to dissolve water-insoluble chemicals. However, our previous study suggested the superiority of…”
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The modified IL-8 Luc assay, an in vitro skin sensitisation test, can significantly improve the false-negative judgment of lipophilic sensitizers with logK ow values > 3.5 by Kimura, Yutaka, Fujimura, Chizu, Aiba, Setsuya

“…False-negative judgment due to poor chemical solubility is a problem with in vitro skin sensitisation tests. Water-insoluble chemicals are typically dissolved…”
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An international validation study of the interleukin-2 luciferase leukocyte toxicity test (IL-2 Luc LTT) to evaluate potential immunosuppressive chemicals and its performance after use with the interleukin-2 luciferase assay (IL-2 Luc assay) by Yutaka, Kimura, Rie, Yasuno, Iwaki, Tomoko, Fujimura, Chizu, Ohmiya, Yoshihiro, Nakajima, Yoshihiro, Omori, Takashi, Corsini, Emanuela, Inoue, Tomoaki, Rogen, Erwin L., Kojima, Hajime, Aiba, Setsuya

“…We previously reported that the IL-2 Luc LTT can detect immunosuppressive effects of drugs that are attributed to their antimitotic activity. Here, we report…”
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Tyrosine Bioconjugation Using Stably Preparable Urazole Radicals by Sato, Shinichi, Miyano, Shogo, Nakane, Keita, Liu, Zhengyi, Kumashiro, Munehiro, Saio, Tomohide, Tanaka, Yuya, Shigenaga, Akira, Fujimura, Chizu, Koyanagi, Eri, Nishi, Hafumi, Tomoshige, Shusuke, Ishikawa, Minoru

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An international validation study of the IL-2 Luc assay for evaluating the potential immunotoxic effects of chemicals on T cells and a proposal for reference data for immunotoxic chemicals by Kimura, Yutaka, Yasuno, Rie, Watanabe, Mika, Kobayashi, Miwako, Iwaki, Tomoko, Fujimura, Chizu, Ohmiya, Yoshihiro, Yamakage, Kohji, Nakajima, Yoshihiro, Kobayashi, Mayumi, Mashimo, Nana, Takagi, Yumi, Omori, Takashi, Corsini, Emanuela, Germolec, Dori, Inoue, Tomoaki, Rogen, Erwin L., Kojima, Hajime, Aiba, Setsuya

“…To evaluate the immunotoxic effects of xenobiotics, we have established the Multi-ImmunoTox assay, in which three stable reporter cell lines are used to…”
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Development of a novel in vitro assay to evaluate environmental water using an IL-8 reporter cell line by Kimura, Yutaka, Fujimura, Chizu, Imagawa, Toshifumi, Lupisan, Socorro P, Saito-Obata, Mariko, Saito, Mayuko, Oshitani, Hitoshi, Aiba, Setsuya

“…The IL-8 luciferase reporter cell line, THP-G8 cells, used in the in vitro sensitization test, OECD442E, can respond to a variety of stimuli other than…”
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