Search Results - "Fujii, Nobuharu L"

Evidence for acute contraction-induced myokine secretion by C2C12 myotubes by Furuichi, Yasuro, Manabe, Yasuko, Takagi, Mayumi, Aoki, Miho, Fujii, Nobuharu L

“…Skeletal muscle is considered a secretory organ that produces bioactive proteins known as myokines, which are released in response to various stimuli. However,…”
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Characterization of an acute muscle contraction model using cultured C2C12 myotubes by Manabe, Yasuko, Miyatake, Shouta, Takagi, Mayumi, Nakamura, Mio, Okeda, Ai, Nakano, Taemi, Hirshman, Michael F, Goodyear, Laurie J, Fujii, Nobuharu L

“…A cultured C2C12 myotube contraction system was examined for application as a model for acute contraction-induced phenotypes of skeletal muscle. C2C12 myotubes…”
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Effect of treatment with conditioned media derived from C2C12 myotube on adipogenesis and lipolysis in 3T3-L1 adipocytes by Tamura, Kotaro, Goto-Inoue, Naoko, Miyata, Kaede, Furuichi, Yasuro, Fujii, Nobuharu L, Manabe, Yasuko

“…Regular exercise is an effective strategy that is used to prevent and treat obesity as well as type 2 diabetes. Exercise-induced myokine secretion is…”
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R-spondin3 is a myokine that differentiates myoblasts to type I fibres by Mita, Yoshitaka, Zhu, Haonan, Furuichi, Yasuro, Hamaguchi, Hiroki, Manabe, Yasuko, Fujii, Nobuharu L.

“…Muscle fibres are broadly categorised into types I and II; the fibre-type ratio determines the contractile and metabolic properties of skeletal muscle tissue…”
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Mass spectrometry imaging reveals local metabolic changes in skeletal muscle due to chronic training by Goto-Inoue, Naoko, Morisasa, Mizuki, Kimura, Keisuke, Mori, Tsukasa, Furuichi, Yasuro, Manabe, Yasuko, Fujii, Nobuharu L

“…Muscle atrophy is a major health problem that needs effective prevention and treatment approaches. Chronic exercise, an effective treatment strategy for…”
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Establishment of a system evaluating the contractile force of electrically stimulated myotubes from wrinkles formed on elastic substrate by Hamaguchi, Hiroki, Matsui, Tsubasa S., Deguchi, Shinji, Furuichi, Yasuro, Fujii, Nobuharu L., Manabe, Yasuko

“…Muscle weakness is detrimental not only to quality of life but also life expectancy. However, effective drugs have still not been developed to improve and…”
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Characterization of myofiber‐type‐specific molecules using mass spectrometry imaging by Goto‐Inoue, Naoko, Morisasa, Mizuki, Machida, Kazumasa, Furuichi, Yasuro, Fujii, Nobuharu L., Miura, Shinji, Mori, Tsukasa

“…Rationale In skeletal muscles, there are four myofiber types, Types I, IIa, IIx, and IIb, which show different contraction characteristics and have different…”
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Lipidomics analysis revealed the phospholipid compositional changes in muscle by chronic exercise and high-fat diet by Goto-Inoue, Naoko, Yamada, Kenichiro, Inagaki, Akiko, Furuichi, Yasuro, Ogino, Shinya, Manabe, Yasuko, Setou, Mitsutoshi, Fujii, Nobuharu L.

“…Although it is clear that lipids are responsible for insulin resistance, it is poorly understood what types of lipids are involved. In this study, we verified…”
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Excess Glucose Impedes the Proliferation of Skeletal Muscle Satellite Cells Under Adherent Culture Conditions by Furuichi, Yasuro, Kawabata, Yuki, Aoki, Miho, Mita, Yoshitaka, Fujii, Nobuharu L, Manabe, Yasuko

“…Glucose is a major energy source consumed by proliferating mammalian cells. Therefore, in general, proliferating cells have the preference of high glucose…”
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Loop diuretics affect skeletal myoblast differentiation and exercise-induced muscle hypertrophy by Mandai, Shintaro, Furukawa, Susumu, Kodaka, Manami, Hata, Yutaka, Mori, Takayasu, Nomura, Naohiro, Ando, Fumiaki, Mori, Yutaro, Takahashi, Daiei, Yoshizaki, Yuki, Kasagi, Yuri, Arai, Yohei, Sasaki, Emi, Yoshida, Sayaka, Furuichi, Yasuro, Fujii, Nobuharu L., Sohara, Eisei, Rai, Tatemitsu, Uchida, Shinichi

“…Muscle wasting or sarcopenia contributes to morbidity and mortality in patients with cancer, renal failure, or heart failure, and in elderly individuals. Na +…”
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A new in vitro muscle contraction model and its application for analysis of mTORC1 signaling in combination with contraction and beta-hydroxy-beta-methylbutyrate administration by Sato, Satoko, Nomura, Mitsuru, Yamana, Ikko, Uchiyama, Akira, Furuichi, Yasuro, Manabe, Yasuko, Fujii, Nobuharu L.

“…Several food constituents augment exercise-induced muscle strength improvement; however, the detailed mechanism underlying these combined effects is unknown…”
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Dammarane-type triterpene extracts of Panax notoginseng root ameliorates hyperglycemia and insulin sensitivity by enhancing glucose uptake in skeletal muscle by Kitamura, Kumiko, Takamura, Yusuke, Iwamoto, Taku, Nomura, Mitsuru, Iwasaki, Hideaki, Ohdera, Motoyasu, Murakoshi, Michiaki, Sugiyama, Keikichi, Matsuyama, Kazuki, Manabe, Yasuko, Fujii, Nobuharu L., Fushiki, Tohru

“…Skeletal muscle is an important organ for controlling the development of type 2 diabetes. We discovered Panax notoginseng roots as a candidate to improve…”
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Discovery of TBC1D1 as an Insulin-, AICAR-, and Contraction-stimulated Signaling Nexus in Mouse Skeletal Muscle by Taylor, Eric B., An, Ding, Kramer, Henning F., Yu, Haiyan, Fujii, Nobuharu L., Roeckl, Katja S.C., Bowles, Nicole, Hirshman, Michael F., Xie, Jianxin, Feener, Edward P., Goodyear, Laurie J.

“…The Akt substrate of 160 kDa (AS160) is phosphorylated on Akt substrate (PAS) motifs in response to insulin and contraction in skeletal muscle, regulating…”
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Stable isotope-labeled carnitine reveals its rapid transport into muscle cells and acetylation during contraction by Furuichi, Yasuro, Goto-Inoue, Naoko, Uchida, Saki, Masuda, Shun, Manabe, Yasuko, Fujii, Nobuharu L.

“…Carnitine plays multiple roles in skeletal muscle metabolism, including fatty acid transport and buffering of excess acetyl-CoA in the mitochondria. The…”
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Imaging mass spectrometry reveals fiber-specific distribution of acetylcarnitine and contraction-induced carnitine dynamics in rat skeletal muscles by Furuichi, Yasuro, Goto-Inoue, Naoko, Manabe, Yasuko, Setou, Mitsutoshi, Masuda, Kazumi, Fujii, Nobuharu L.

“…Carnitine is well recognized as a key regulator of long-chain fatty acyl group translocation into the mitochondria. In addition, carnitine, as acetylcarnitine,…”
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An improved glucose transport assay system for isolated mouse skeletal muscle tissues by Inagaki, Akiko, Maruo, Kanoko, Furuichi, Yasuro, Miyatake, Shouta, Tamura, Kotaro, Fujii, Nobuharu L., Manabe, Yasuko

“…There is a growing demand for a system in the field of sarcopenia and diabetes research that could be used to evaluate the effects of functional food…”
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Macrophage migration inhibitory factor diminishes muscle glucose transport induced by insulin and AICAR in a muscle type-dependent manner by Miyatake, Shouta, Manabe, Yasuko, Inagaki, Akiko, Furuichi, Yasuro, Takagi, Mayumi, Taoka, Masato, Isobe, Toshiaki, Hirota, Kiichi, Fujii, Nobuharu L.

“…•MIF is a myokine secreted from C2C12 myotubes and skeletal muscles.•MIF decreases glucose transport induced by insulin in the soleus muscle.•MIF decreases…”
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Effect of chronic muscle contraction on expression of contractile and metabolic proteins in mouse primary cultured myotubes by Mita, Yoshitaka, Ito, Miyuki, Yamada, Mio, Fujii, Nobuharu L., Manabe, Yasuko, Furuichi, Yasuro

“…Endurance exercise induces skeletal muscle adaptations such as fiber-type switching, mitochondrial biogenesis, angiogenesis, and the enhancement of glucose…”
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Evaluation of an in vitro muscle contraction model in mouse primary cultured myotubes by Manabe, Yasuko, Ogino, Shinya, Ito, Miyuki, Furuichi, Yasuro, Takagi, Mayumi, Yamada, Mio, Goto-Inoue, Naoko, Ono, Yusuke, Fujii, Nobuharu L.

“…To construct an in vitro contraction model with the primary cultured myotubes, we isolated satellite cells from the mouse extensor digitorum longus…”
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Trans-omic Analysis Reveals ROS-Dependent Pentose Phosphate Pathway Activation after High-Frequency Electrical Stimulation in C2C12 Myotubes by Hoshino, Daisuke, Kawata, Kentaro, Kunida, Katsuyuki, Hatano, Atsushi, Yugi, Katsuyuki, Wada, Takumi, Fujii, Masashi, Sano, Takanori, Ito, Yuki, Furuichi, Yasuro, Manabe, Yasuko, Suzuki, Yutaka, Fujii, Nobuharu L., Soga, Tomoyoshi, Kuroda, Shinya

“…Skeletal muscle adaptation is mediated by cooperative regulation of metabolism, signal transduction, and gene expression. However, the global regulatory…”
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