Search Results - "Fujihashi, Keiko"

Potential roles of CCR5(+) CCR6(+) dendritic cells induced by nasal ovalbumin plus Flt3 ligand expressing adenovirus for mucosal IgA responses by Fukuyama, Yoshiko, Tokuhara, Daisuke, Sekine, Shinichi, Aso, Kazuyoshi, Kataoka, Kosuke, Davydova, Julia, Yamamoto, Masato, Gilbert, Rebekah S, Tokuhara, Yuka, Fujihashi, Keiko, Kunisawa, Jun, Yuki, Yoshikazu, Kiyono, Hiroshi, McGhee, Jerry R, Fujihashi, Kohtaro

“…We assessed the role of CCR5(+)/CCR6(+)/CD11b(+)/CD11c(+) dendritic cells (DCs) for induction of ovalbumin (OVA)-specific antibody (Ab) responses following…”
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Oral-nasopharyngeal dendritic cells mediate T cell-independent IgA class switching on B-1 B cells by Kataoka, Kosuke, Fujihashi, Keiko, Terao, Yutaka, Gilbert, Rebekah S, Sekine, Shinichi, Kobayashi, Ryoki, Fukuyama, Yoshiko, Kawabata, Shigetada, Fujihashi, Kohtaro

“…Native cholera toxin (nCT) as a nasal adjuvant was shown to elicit increased levels of T-independent S-IgA antibody (Ab) responses through IL-5- IL-5 receptor…”
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A Novel Adenovirus Expressing Flt3 Ligand Enhances Mucosal Immunity by Inducing Mature Nasopharyngeal-Associated Lymphoreticular Tissue Dendritic Cell Migration by Sekine, Shinichi, Kataoka, Kosuke, Fukuyama, Yoshiko, Adachi, Yasuo, Davydova, Julia, Yamamoto, Masato, Kobayashi, Ryoki, Fujihashi, Keiko, Suzuki, Hideaki, Curiel, David T, Shizukuishi, Satoshi, McGhee, Jerry R, Fujihashi, Kohtaro

“…Previously, we showed that nasal administration of a naked cDNA plasmid expressing Flt3 ligand (FL) cDNA (pFL) enhanced CD4(+) Th2-type, cytokine-mediated…”
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Nasal Flt3 Ligand cDNA Elicits CD11c+CD8+ Dendritic Cells for Enhanced Mucosal Immunity by Kataoka, Kosuke, McGhee, Jerry R, Kobayashi, Ryoki, Fujihashi, Keiko, Shizukuishi, Satoshi, Fujihashi, Kohtaro

“…Nasal immunization is an effective way to induce both mucosal and systemic immune responses. In this study, we assessed a cDNA vector for Flt3 ligand (FL) for…”
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A Molecular Mucosal Adjuvant To Enhance Immunity Against Pneumococcal Infection In The Elderly by Fukuyama, Yoshiko, Ikeda, Yorihiko, Ohori, Junichiro, Sugita, Gen, Aso, Kazuyoshi, Fujihashi, Keiko, Briles, David E, McGhee, Jerry R, Fujihashi, Kohtaro

“…Streptococcus pneumoniae (the pneumococcus) causes a major upper respiratory tract infection often leading to severe illness and death in the elderly. Thus, it…”
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Lack of oral tolerance in aging is due to sequential loss of Peyer’s patch cell interactions by Kato, Hirotomo, Fujihashi, Kohtaro, Kato, Rie, Dohi, Taeko, Fujihashi, Keiko, Hagiwara, Yukari, Kataoka, Kosuke, Kobayashi, Ryoki, McGhee, Jerry R.

“…Our past studies showed that Peyer’s patches were required for the induction of oral tolerance to the protein antigen ovalbumin (OVA), but not to the hapten…”
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A Molecular Mucosal Adjuvant To Enhance Immunity Against Pneumococcal Infection In The Elderly by Fukuyama, Yoshiko, Ikeda, Yorihiko, Ohori, Junichiro, Sugita, Gen, Aso, Kazuyoshi, Fujihashi, Keiko, Briles, David E, McGhee, Jerry R, Fujihashi, Kohtaro

“…Streptococcus pneumoniae (the pneumococcus) causes a major upper respiratory tract infection often leading to severe illness and death in the elderly. Thus, it…”
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PspA-based sublingual vaccine provides IgA dependent protective immunity to nasopharyngeal carriage by Streptococcus pneumoniae by Nagano, Hiromi, SUGITA, Gen, SUGITA, rinya, Ikeda, Yorihiko, Fujihashi, Keiko, Tsuruhara, Akitoshi, Kurono, Yuichi, Fujihashi, Kohtaro

“…Abstract Pneumococcal infection caused by Streptococcus pneumoniae is a major upper respiratory tract disease which causes severe illness and mortality. It is…”
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Nasal plasmid Flt3 ligand and CpG ODN alone enhances immediate, influenza virus-specific recall secretory IgA Ab responses in aging (MUC1P.904) by Ohori, Junichiro, Asanuma, Hideki, Aso, Kazuyoshi, Ikeda, Yorihiko, Sugita, Gen, Fujihashi, Keiko, McGhee, Jerry, Fujihashi, Kohtaro

“…Abstract The elderly have already experienced various pathogens and thus possess pathogen-specific Abs, whose titers are too low to combat reinfection. Thus,…”
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A novel combined adjuvant for nasal delivery elicits mucosal immunity to influenza in aging by Asanuma, Hideki, Zamri, Normaiza Binti, Sekine, Shinichi, Fukuyama, Yoshiko, Tokuhara, Daisuke, Gilbert, Rebekah S, Fukuiwa, Tatsuya, Fujihashi, Keiko, Sata, Tetsutaro, Tashiro, Masato, Fujihashi, Kohtaro

“…Highlights ► We examined whether pFL and CpG-ODN could induce influenza-specific protective immunity in aged mice. ► A combination of pFL and CpG-ODN elicits a…”
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Ovalbumin-protein sigma 1 M-cell targeting facilitates oral tolerance with reduction of antigen-specific CD4+ T cells by Suzuki, Hideaki, Sekine, Shinichi, Kataoka, Kosuke, Pascual, David W, Maddaloni, Massimo, Kobayashi, Ryoki, Fujihashi, Keiko, Kozono, Haruo, McGhee, Jerry R, Fujihashi, Kohtaro

“…The follicle-associated epithelium (FAE) plays key roles in antigen uptake and subsequent induction of mucosal immunity. In this study, we examined whether…”
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Ovalbumin-Protein σ1 M-Cell Targeting Facilitates Oral Tolerance With Reduction of Antigen-Specific CD4+ T Cells by Suzuki, Hideaki, Sekine, Shinichi, Kataoka, Kosuke, Pascual, David W, Maddaloni, Massimo, Kobayashi, Ryoki, Fujihashi, Keiko, Kozono, Haruo, McGhee, Jerry R, Fujihashi, Kohtaro

“…Background & Aims: The follicle-associated epithelium (FAE) plays key roles in antigen uptake and subsequent induction of mucosal immunity. In this study, we…”
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Potential Roles of CCR5.sup.+ CCR6.sup.+ Dendritic Cells Induced by Nasal Ovalbumin plus Flt3 Ligand Expressing Adenovirus for Mucosal IgA Responses by Fukuyama, Yoshiko, Tokuhara, Daisuke, Sekine, Shinichi, Aso, Kazuyoshi, Kataoka, Kosuke, Davydova, Julia, Yamamoto, Masato, Gilbert, Rebekah S, Tokuhara, Yuka, Fujihashi, Keiko, Kunisawa, Jun, Yuki, Yoshikazu, Kiyono, Hiroshi, McGhee, Jerry R, Fujihashi, Kohtaro

“…We assessed the role of CCR5.sup.+ /CCR6.sup.+ /CD11b.sup.+ /CD11c.sup.+ dendritic cells (DCs) for induction of ovalbumin (OVA)-specific antibody (Ab)…”
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Notch-ligand expression by NALT dendritic cells regulates mucosal Th1- and Th2-type responses by Fukuyama, Yoshiko, Tokuhara, Daisuke, Sekine, Shinichi, Kataoka, Kosuke, Markham, Jonathan D., Irwin, Allyson R., Moon, Grace H., Tokuhara, Yuka, Fujihashi, Keiko, Davydova, Julia, Yamamoto, Masato, Gilbert, Rebekah S., Fujihashi, Kohtaro

“…► Nasal Ad-FL effectively up-regulates APC function by CD11c+ DCs in mucosal tissues. ► Nasal Ad-FL induces Notch ligand (L)-expressing CD11c+ DCs. ► Notch…”
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Notch-Ligand Expression By NALT Dendritic Cells Regulates Mucosal Th1- and Th2-Type Responses1 by Fukuyama, Yoshiko, Tokuhara, Daisuke, Sekine, Shinichi, Kataoka, Kosuke, Markham, Jonathan D., Irwin, Allyson R., Moon, Grace H., Tokuhara, Yuka, Fujihashi, Keiko, Davydova, Julia, Yamamoto, Masato, Gilbert, Rebekah S., Fujihashi, Kohtaro

“…Our previous studies showed that an adenovirus (Ad) serotype 5 vector expressing Flt3 ligand (Ad-FL) as nasal adjuvant activates CD11c + dendritic cells (DCs)…”
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Nasal cholera toxin elicits IL-5 and IL-5 receptor alpha-chain expressing B-1a B cells for innate mucosal IgA antibody responses by Kataoka, Kosuke, Fujihashi, Keiko, Sekine, Shinichi, Fukuiwa, Tatsuya, Kobayashi, Ryoki, Suzuki, Hideaki, Nagata, Hideki, Takatsu, Kiyoshi, Shizukuishi, Satoshi, McGhee, Jerry R, Fujihashi, Kohtaro

“…In this study, we examine whether native cholera toxin (nCT) as a mucosal adjuvant can support trinitrophenyl (TNP)-LPS-specific mucosal immune responses…”
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Protective Mucosal Immunity in Aging Is Associated with Functional CD4+ T Cells in Nasopharyngeal-Associated Lymphoreticular Tissue by Hagiwara, Yukari, McGhee, Jerry R, Fujihashi, Keiko, Kobayashi, Ryoki, Yoshino, Naoto, Kataoka, Kosuke, Etani, Yuri, Kweon, Mi-Na, Tamura, Shinichi, Kurata, Takeshi, Takeda, Yoshifumi, Kiyono, Hiroshi, Fujihashi, Kohtaro

“…Our previous studies showed that mucosal immunity was impaired in 1-year-old mice that had been orally immunized with OVA and native cholera toxin (nCT) as…”
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Nasal Cholera Toxin Up‐regulates Mucosal DCs And B1 B Cells Interactions For The Induction Of Innate IgA CSR by KATAOKA, KOSUKE, Fujihashi, Keiko, Sekine, Shinichi, Kobayashi, Ryoki, Sims, Rebekah, Ito, Hiroo, McGhee, Jerry R, Shizukuishi, Satoshi, Fujihashi, Kohtaro

“…Abstract only Our previous study showed that nasal immunization with TNP‐LPS plus cholera toxin (CT) as mucosal adjuvant elicited increased levels of mucosal…”
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Non-GMI Ganglioside-Targeting Bacterial Toxins and Derivatives with Mucosal Adjuvant Activity by Duverger, Alexandra, Kobayashi, Ryoki, Fukuiwa, Tatsuya, Fujihashi, Keiko, Tome, Daniel, Fujihashi, Kohtaro, McGhee, Jerry R., Boyaka, Prosper N.

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A Novel Adenovirus Expressing Flt3 Ligand Enhances Mucosal Immunity by Inducing Mature Nasopharyngeal-Associated Lymphoreticular Tissue Dendritic Cell Migration1 by Sekine, Shinichi, Kataoka, Kosuke, Fukuyama, Yoshiko, Adachi, Yasuo, Davydova, Julia, Yamamoto, Masato, Kobayashi, Ryoki, Fujihashi, Keiko, Suzuki, Hideaki, Curiel, David T., Shizukuishi, Satoshi, McGhee, Jerry R., Fujihashi, Kohtaro

“…Previously, we showed that nasal administration of a naked cDNA plasmid expressing Flt3 ligand (FL) cDNA (pFL) enhanced CD4 + Th2-type, cytokine-mediated…”
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