Search Results - "Fujihara, C K"

Sodium excess aggravates hypertension and renal parenchymal injury in rats with chronic NO inhibition by Fujihara, C K, Michellazzo, S M, de Nucci, G, Zatz, R

“…Chronic nitric oxide (NO) inhibition promotes hypertension and ischemic glomerular injury with only minor glomerulosclerosis (GS). We evaluated the effect of…”
Get full text

Effects of losartan, in monotherapy or in association with hydrochlorothiazide, in chronic nephropathy resulting from losartan treatment during lactation by Fanelli, C, Fernandes, B H V, Machado, F G, Okabe, C, Malheiros, D M A C, Fujihara, C K, Zatz, R

“…We recently standardized a model (L(Lact)) of severe chronic kidney disease based on impaired nephrogenesis by suppression of angiotensin II activity during…”
Get more information

Effect of Salt Intake and Inhibitor Dose on Arterial Hypertension and Renal Injury Induced by Chronic Nitric Oxide Blockade by Yamada, Sergio Seiji, Sassaki, Ana Lucia, Fujihara, Clarice Kazue, Malheiros, Denise Maria Avancini Costa, De Nucci, Gilberto, Zatz, Roberto

“…Long-term nitric oxide blockade by N -nitro-L-arginine methyl ester (L-NAME) leads to severe and progressive hypertension. The role of salt intake in this…”
Get full text

Glomerular abnormalities in long-term experimental diabetes. Role of hemodynamic and nonhemodynamic factors and effects of antihypertensive therapy by Fujihara, C. K., Padilha, R. M., Zatz, R.

“…Glomerular abnormalities in long-term experimental diabetes. Role of hemodynamic and nonhemodynamic factors and effects of antihypertensive therapy. C K…”
Get full text

Renal effects of acute and chronic nitric oxide inhibition in experimental diabetes by Mattar, A L, Fujihara, C K, Ribeiro, M O, de Nucci, G, Zatz, R

“…We investigated whether nitric oxide (NO) contributes to glomerular hyperfiltration in experimental diabetes. Thirty-five adult male Munich-Wistar…”
Get more information

Glomerular hypertrophy and progressive glomerulopathy. Is there a definite pathogenetic correlation? by Zatz, R, Fujihara, C K

Get more information

Absence of focal glomerulosclerosis in aging analbuminemic rats by Fujihara, C K, Limongi, D M, De Oliveira, H C, Zatz, R

“…The Nagase analbuminemic rat (NAR), a mutant of the Sprague-Dawley (SD) strain, exhibits high levels of plasma cholesterol (Chol), thrombocytosis, and enhanced…”
Get full text

Mycophenolate mofetil attenuates renal injury in the rat remnant kidney by Fujihara, Clarice Kazue, Malheiros, Denise Maria Avancini Costa, Zatz, Roberto, Noronha, Irene de Lourdes

“…Mycophenolate mofetil attenuates renal injury in the rat remnant kidney. Mycophenolate mofetil (MMF), an inhibitor of lymphocyte proliferation, has been used…”
Get full text

Pathogenesis of glomerular sclerosis in subtotally nephrectomized analbuminemic rats by Fujihara, C K, Limongi, D M, Falzone, R, Graudenz, M S, Zatz, R

“…The Nagase analbuminemic rat (NAR), a mutant of the Sprague-Dawley (SD) strain, exhibits persistent hypercholesterolemia, thrombocytosis, and enhanced platelet…”
Get full text

Combined mycophenolate mofetil and losartan therapy arrests established injury in the remnant kidney by FUJIHARA, C. K, DE LOURDES NORONHA, I, AVANCINI COSTA MALHEIROS, D. M, ANTUNES, G. R, DE OLIVEIRA, I. B, ZATZ, R

“…Previously it was shown that early treatment with mycophenolate mofetil (MMF) attenuated renal inflammation, glomerulosclerosis (GS), and interstitial…”
Get full text

Statin monotherapy attenuates renal injury in a salt-sensitive hypertension model of renal disease by Vieira, Jr, J M, Rodrigues, L T, Mantovani, E, Dellê, H, Mattar, A L, Malheiros, D M A C, Noronha, I L, Fujihara, C K, Zatz, R

“…Several salutary biological effects of statins have been described. We sought to investigate more closely the anti-inflammatory and antiproliferative effects…”
Get more information

Nitroflurbiprofen, a new nonsteroidal anti-inflammatory, ameliorates structural injury in the remnant kidney by Fujihara, C K, Malheiros, D M, Donato, J L, Poli, A, De Nucci, G, Zatz, R

“…Cyclooxygenase derivatives and nitric oxide (NO) may influence the pathogenesis of progressive nephropathies. We investigated the effect of nitroflurbiprofen…”
Get full text

Chronic nitric oxide synthase inhibition aggravates glomerular injury in rats with subtotal nephrectomy by Fujihara, C K, De Nucci, G, Zatz, R

“…Besides its glomerular hemodynamic effects, nitric oxide (NO) inhibits platelet aggregation and mesangial cell proliferation, two mechanisms possibly involved…”
Get full text

Mechanisms of albuminuria in the chronic nitric oxide inhibition model by Arcos, M I, Fujihara, C K, Sesso, A, de Almeida Prado, E B, de Almeida Prado, M J, de Nucci, G, Zatz, R

“…Chronic nitric oxide (NO) inhibition causes hypertension and renal injury. Concomitant salt overload promotes massive albuminuria. We investigated the…”
Get more information

Sodium handling and renal hemodynamics in euvolemic and volume-expanded nephrotic rats by Zatz, R, Fujihara, C K, Marcondes, M

“…Normal (N) rats and rats with nephrotoxic serum nephritis (NSN) were used in whole-kidney and micropuncture studies while being kept euvolemic by homologous…”
Get more information

NLRP3 inflammasome inhibition ameliorates tubulointerstitial injury in the remnant kidney model by Foresto-Neto, Orestes, Ávila, Victor Ferreira, Arias, Simone Costa Alarcon, Zambom, Fernanda Florencia Fregnan, Rempel, Lisienny Campoli Tono, Faustino, Viviane Dias, Machado, Flavia Gomes, Malheiros, Denise Maria Avancini Costa, Abensur, Hugo, Camara, Niels Olsen Saraiva, Zatz, Roberto, Fujihara, Clarice Kazue

“…Recent studies suggest that NLRP3 inflammasome activation is involved in the pathogenesis of chronic kidney disease (CKD). Allopurinol (ALLO) inhibits xanthine…”
Get full text

Mycophenolate mofetil prevents the development of glomerular injury in experimental diabetes by UTIMURA, Ricardo, FUJIHARA, Clarice Kazue, MATTAR, Ana Lucia, AVANCINI COSTA MALHEIROS, Denise Maria, NORONHA, Irene De, ZATZ, Roberto

“…Experimental and clinical evidence suggests that inflammation plays a role in the pathogenesis of diabetic nephropathy, in addition to, or in concert with, the…”
Get full text

An extremely high dose of losartan affords superior renoprotection in the remnant model by Fujihara, Clarice Kazue, Velho, Mariliza, Malheiros, Denise Mariaavancini Costa, Zatz, Roberto

“…An extremely high dose of losartan affords superior renoprotection in the remnant model. Rats subjected to 5/6 renal ablation (NX) exhibit large renal amounts…”
Get full text

The inflammatory component in progressive renal disease—are interventions possible? by Noronha, Irene L., Fujihara, Clarice K., Zatz, Roberto

Get full text

Simvastatin attenuates renal inflammation, tubular transdifferentiation and interstitial fibrosis in rats with unilateral ureteral obstruction by Mauro Vieira, José, Mantovani, Eduardo, Tavares Rodrigues, Leonardo, Dellê, Humberto, Noronha, Irene Lourdes, Fujihara, Clarice Kazue, Zatz, Roberto

“…Background. The pleiotropic actions of statins have been largely explored. These drugs have been tested in several models of progressive renal disease, most of…”
Get full text