Search Results - "Fuhs, Stephen R."

Identification of PGAM5 as a Mammalian Protein Histidine Phosphatase that Plays a Central Role to Negatively Regulate CD4+ T Cells by Panda, Saswati, Srivastava, Shekhar, Li, Zhai, Vaeth, Martin, Fuhs, Stephen R., Hunter, Tony, Skolnik, Edward Y.

“…Whereas phosphorylation of serine, threonine, and tyrosine is exceedingly well characterized, the role of histidine phosphorylation in mammalian signaling is…”
Get full text

Histidine phosphorylation relieves copper inhibition in the mammalian potassium channel KCa3.1 by Srivastava, Shekhar, Panda, Saswati, Li, Zhai, Fuhs, Stephen R, Hunter, Tony, Thiele, Dennis J, Hubbard, Stevan R, Skolnik, Edward Y

“…KCa2.1, KCa2.2, KCa2.3 and KCa3.1 constitute a family of mammalian small- to intermediate-conductance potassium channels that are activated by…”
Get full text

The protein histidine phosphatase LHPP is a tumour suppressor by Hindupur, Sravanth K., Colombi, Marco, Fuhs, Stephen R., Matter, Matthias S., Guri, Yakir, Adam, Kevin, Cornu, Marion, Piscuoglio, Salvatore, Ng, Charlotte K. Y., Betz, Charles, Liko, Dritan, Quagliata, Luca, Moes, Suzette, Jenoe, Paul, Terracciano, Luigi M., Heim, Markus H., Hunter, Tony, Hall, Michael N.

“…Decreased expression of histidine phosphatase LHPP, a novel tumour suppressor, results in increased global histidine phosphorylation and hepatocellular…”
Get full text

Development of a virtual reality platform for effective communication of structural data in drug discovery by Kingsley, Laura J., Brunet, Vincent, Lelais, Gerald, McCloskey, Steve, Milliken, Kelly, Leija, Edgardo, Fuhs, Stephen R., Wang, Kai, Zhou, Edward, Spraggon, Glen

“…In drug discovery, structural knowledge of a target enables structure-based design approaches and thereby reduces the time and labor required to develop a…”
Get full text

Structural basis for differential recognition of phosphohistidine-containing peptides by 1-pHis and 3-pHis monoclonal antibodies by Kalagiri, Rajasree, Stanfield, Robyn L., Meisenhelder, Jill, La Clair, James J., Fuhs, Stephen R., Wilson, Ian A., Hunter, Tony

“…In 2015, monoclonal antibodies (mAbs) that selectively recognize the 1-pHis or 3-pHis isoforms of phosphohistidine were developed by immunizing rabbits with…”
Get full text

Pharmacology and signaling properties of epidermal growth factor receptor isoforms studied by bioluminescence resonance energy transfer by Schiffer, Hans H, Reding, Esther C, Fuhs, Stephen R, Lu, Qing, Piu, Fabrice, Wong, Steven, Littler, Pey-Lih H, Weiner, Dave M, Keefe, William, Tan, Phil K, Nash, Norman R, Knapp, Anne E, Olsson, Roger, Brann, Mark R

“…We have developed a new assay for measuring epidermal growth factor receptor (EGFR) activation using the bioluminescence resonance energy transfer (BRET)…”
Get more information

Caveolin-3 undergoes SUMOylation by the SUMO E3 ligase PIASy: sumoylation affects G-protein-coupled receptor desensitization by Fuhs, Stephen R, Insel, Paul A

“…Caveolin (Cav) proteins in the plasma membrane have numerous binding partners, but the determinants of these interactions are poorly understood. We show here…”
Get full text

Caveolin-3 Undergoes SUMOylation by the SUMO E3 Ligase PIASy by Fuhs, Stephen R., Insel, Paul A.

“…Caveolin (Cav) proteins in the plasma membrane have numerous binding partners, but the determinants of these interactions are poorly understood. We show here…”
Get full text

SUMOylation of caveolin‐3: SUMO‐specific proteases SENP1 and SENP2 regulate deconjugation of SUMO‐3 and poly‐SUMO‐3 chains by Busija, Anna Rebecca, Fuhs, Stephen R., Patel, Hemal H., Insel, Paul A.

“…Abstract only Mechanisms that regulate the interaction of caveolins with partners are poorly understood. We recently reported (JBC 286:14830–41 [2011]) the…”
Get full text