Search Results - "Fuertes Marraco, Silvia A"

Inhibitory Receptors Beyond T Cell Exhaustion by Fuertes Marraco, Silvia A, Neubert, Natalie J, Verdeil, Grégory, Speiser, Daniel E

“…Inhibitory receptors (iRs) are frequently associated with "T cell exhaustion". However, the expression of iRs is also dependent on T cell differentiation and…”
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Extended co-expression of inhibitory receptors by human CD8 T-cells depending on differentiation, antigen-specificity and anatomical localization by Baitsch, Lukas, Legat, Amandine, Barba, Leticia, Fuertes Marraco, Silvia A, Rivals, Jean-Paul, Baumgaertner, Petra, Christiansen-Jucht, Céline, Bouzourene, Hanifa, Rimoldi, Donata, Pircher, Hanspeter, Rufer, Nathalie, Matter, Maurice, Michielin, Olivier, Speiser, Daniel E

“…Inhibitory receptors mediate CD8 T-cell hyporesponsiveness against cancer and infectious diseases. PD-1 and CTLA-4 have been extensively studied, and blocking…”
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Very Late Antigen-1 Marks Functional Tumor-Resident CD8 T Cells and Correlates with Survival of Melanoma Patients by Murray, Timothy, Fuertes Marraco, Silvia A, Baumgaertner, Petra, Bordry, Natacha, Cagnon, Laurène, Donda, Alena, Romero, Pedro, Verdeil, Grégory, Speiser, Daniel E

“…A major limiting factor in the success of immunotherapy is tumor infiltration by CD8 T cells, a process that remains poorly understood. In the present study,…”
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LAG-3 and PD-1+LAG-3 inhibition promote anti-tumor immune responses in human autologous melanoma/T cell co-cultures by Gestermann, Nicolas, Saugy, Damien, Martignier, Christophe, Tillé, Laure, Fuertes Marraco, Silvia A., Zettl, Markus, Tirapu, Iñigo, Speiser, Daniel E., Verdeil, Grégory

“…Despite the success of immunotherapy using checkpoint blockade, many patients with solid tumors remain refractory to these treatments. In human cancer, the…”
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Intratumoral Tcf1+PD-1+CD8+ T Cells with Stem-like Properties Promote Tumor Control in Response to Vaccination and Checkpoint Blockade Immunotherapy by Siddiqui, Imran, Schaeuble, Karin, Chennupati, Vijaykumar, Fuertes Marraco, Silvia A., Calderon-Copete, Sandra, Pais Ferreira, Daniela, Carmona, Santiago J., Scarpellino, Leonardo, Gfeller, David, Pradervand, Sylvain, Luther, Sanjiv A., Speiser, Daniel E., Held, Werner

“…Checkpoint blockade mediates a proliferative response of tumor-infiltrating CD8+ T lymphocytes (TILs). The origin of this response has remained elusive because…”
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Broad and Conserved Immune Regulation by Genetically Heterogeneous Melanoma Cells by Neubert, Natalie J, Tillé, Laure, Barras, David, Soneson, Charlotte, Baumgaertner, Petra, Rimoldi, Donata, Gfeller, David, Delorenzi, Mauro, Fuertes Marraco, Silvia A, Speiser, Daniel E

“…Although mutations drive cancer, it is less clear to what extent genetic defects control immune mechanisms and confer resistance to T-cell-based immunotherapy…”
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Novel murine dendritic cell lines: a powerful auxiliary tool for dendritic cell research by Fuertes Marraco, Silvia A, Grosjean, Frédéric, Duval, Anaïs, Rosa, Muriel, Lavanchy, Christine, Ashok, Devika, Haller, Sergio, Otten, Luc A, Steiner, Quynh-Giao, Descombes, Patrick, Luber, Christian A, Meissner, Felix, Mann, Matthias, Szeles, Lajos, Reith, Walter, Acha-Orbea, Hans

“…Research in vitro facilitates discovery, screening, and pilot experiments, often preceding research in vivo. Several technical difficulties render Dendritic…”
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A Well-Controlled Experimental System to Study Interactions of Cytotoxic T Lymphocytes with Tumor Cells by Neubert, Natalie J, Soneson, Charlotte, Barras, David, Baumgaertner, Petra, Rimoldi, Donata, Delorenzi, Mauro, Fuertes Marraco, Silvia A, Speiser, Daniel E

“…While T cell-based immunotherapies are steadily improving, there are still many patients who progress, despite T cell-infiltrated tumors. Emerging evidence…”
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T cells maintain an exhausted phenotype after antigen withdrawal and population reexpansion by Utzschneider, Daniel T, Legat, Amandine, Fuertes Marraco, Silvia A, Carrié, Lucie, Luescher, Immanuel, Speiser, Daniel E, Zehn, Dietmar

“…During chronic infection, pathogen-specific CD8 + T cells are thought to terminally differentiate into exhausted cells. However, Zehn and colleagues show that…”
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Human TSCM cell dynamics in vivo are compatible with long-lived immunological memory and stemness by Costa Del Amo, Pedro, Lahoz-Beneytez, Julio, Boelen, Lies, Ahmed, Raya, Miners, Kelly L, Zhang, Yan, Roger, Laureline, Jones, Rhiannon E, Marraco, Silvia A Fuertes, Speiser, Daniel E, Baird, Duncan M, Price, David A, Ladell, Kristin, Macallan, Derek, Asquith, Becca

“…Adaptive immunity relies on the generation and maintenance of memory T cells to provide protection against repeated antigen exposure. It has been hypothesised…”
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Long-lasting stem cell-like memory CD8+ T cells with a naïve-like profile upon yellow fever vaccination by Fuertes Marraco, Silvia A, Soneson, Charlotte, Cagnon, Laurène, Gannon, Philippe O, Allard, Mathilde, Abed Maillard, Samia, Montandon, Nicole, Rufer, Nathalie, Waldvogel, Sophie, Delorenzi, Mauro, Speiser, Daniel E

“…Efficient and persisting immune memory is essential for long-term protection from infectious and malignant diseases. The yellow fever (YF) vaccine is a live…”
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Inhibitory Receptor Expression Depends More Dominantly on Differentiation and Activation than "Exhaustion" of Human CD8 T Cells by Legat, Amandine, Speiser, Daniel E, Pircher, Hanspeter, Zehn, Dietmar, Fuertes Marraco, Silvia A

“…Under conditions of chronic antigen stimulation, such as persistent viral infection and cancer, CD8 T cells may diminish effector function, which has been…”
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From T cell “exhaustion” to anti-cancer immunity by Verdeil, Grégory, Fuertes Marraco, Silvia A., Murray, Timothy, Speiser, Daniel E.

“…The immune system has the potential to protect from malignant diseases for extended periods of time. Unfortunately, spontaneous immune responses are often…”
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Genome-wide RNA profiling of long-lasting stem cell-like memory CD8 T cells induced by Yellow Fever vaccination in humans by Fuertes Marraco, Silvia A., Soneson, Charlotte, Delorenzi, Mauro, Speiser, Daniel E.

“…The live-attenuated Yellow Fever (YF) vaccine YF-17D induces a broad and polyfunctional CD8 T cell response in humans. Recently, we identified a population of…”
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T cell receptor alpha variable 12‐2 bias in the immunodominant response to Yellow fever virus by Bovay, Amandine, Zoete, Vincent, Dolton, Garry, Bulek, Anna M., Cole, David K., Rizkallah, Pierre J., Fuller, Anna, Beck, Konrad, Michielin, Olivier, Speiser, Daniel E., Sewell, Andrew K., Fuertes Marraco, Silvia A.

“…The repertoire of human αβ T‐cell receptors (TCRs) is generated via somatic recombination of germline gene segments. Despite this enormous variation, certain…”
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Minimal immune response to booster vaccination against Yellow Fever associated with pre-existing antibodies by Bovay, Amandine, Nassiri, Sina, Maby–El Hajjami, Hélène, Marcos Mondéjar, Paula, Akondy, Rama S., Ahmed, Rafi, Lawson, Benton, Speiser, Daniel E., Fuertes Marraco, Silvia A.

“…•Global immune characterization of YF-17D primary and booster vaccination.•Reduced immune responses to boost compared to priming in adult…”
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Yellow fever virus vaccination: an emblematic model to elucidate robust human immune responses by Bovay, Amandine, Fuertes Marraco, Silvia A., Speiser, Daniel E.

“…By preventing infectious diseases, vaccines contribute substantially to public health. Besides, they offer great opportunities to investigate human immune…”
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Type I interferon drives dendritic cell apoptosis via multiple BH3-only proteins following activation by PolyIC in vivo by Fuertes Marraco, Silvia A, Scott, Clare L, Bouillet, Philippe, Ives, Annette, Masina, Slavica, Vremec, David, Jansen, Elisa S, O'Reilly, Lorraine A, Schneider, Pascal, Fasel, Nicolas, Shortman, Ken, Strasser, Andreas, Acha-Orbea, Hans

“…DC are activated by pathogen-associated molecular patterns (PAMPs), and this is pivotal for the induction of adaptive immune responses. Thereafter, the…”
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Early drop of circulating T cells negatively correlates with the protective immune response to Yellow Fever vaccination by Bovay, Amandine, Speiser, Daniel E, Fuertes Marraco, Silvia A

“…Lymphocyte recirculation within the human body is essential for efficient pathogen detection and immune responses. So far, immune cell migration has been…”
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TLR3-Mediated CD8+ Dendritic Cell Activation Is Coupled with Establishment of a Cell-Intrinsic Antiviral State by Széles, Lajos, Meissner, Felix, Dunand-Sauthier, Isabelle, Thelemann, Christoph, Hersch, Micha, Singovski, Simon, Haller, Sergio, Gobet, Florian, Fuertes Marraco, Silvia A, Mann, Matthias, Garcin, Dominique, Acha-Orbea, Hans, Reith, Walter

“…Because of their unique capacity to cross-present Ags to CD8(+) T cells, mouse lymphoid tissue-resident CD8(+) dendritic cells (DCs) and their migratory…”
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