Search Results - "Fuentes‐Duculan, Judilyn"

Molecular profiling of contact dermatitis skin identifies allergen-dependent differences in immune response by Dhingra, Nikhil, BS, Shemer, Avner, MD, Correa da Rosa, Joel, PhD, Rozenblit, Mariya, BA, Fuentes-Duculan, Judilyn, MD, Gittler, Julia K., MD, Finney, Robert, MD, Czarnowicki, Tali, MD, Zheng, Xiuzhong, MSc, Xu, Hui, MSc, Estrada, Yeriel D., BS, Cardinale, Irma, MSc, Suárez-Fariñas, Mayte, PhD, Krueger, James G., MD, PhD, Guttman-Yassky, Emma, MD, PhD

“…Background Allergic contact dermatitis (ACD) is the most common occupational disease. Although murine contact hypersensitivity provides a framework for…”
Get full text

Comparative Genomic Profiling of Synovium Versus Skin Lesions in Psoriatic Arthritis by Belasco, Jennifer, Louie, James S., Gulati, Nicholas, Wei, Nathan, Nograles, Kristine, Fuentes‐Duculan, Judilyn, Mitsui, Hiroshi, Suárez‐Fariñas, Mayte, Krueger, James G.

“…Objective To our knowledge, there is no broad genomic analysis comparing skin and synovium in psoriatic arthritis (PsA). Also, there is little understanding of…”
Get full text

Biomarkers of alopecia areata disease activity and response to corticosteroid treatment by Fuentes-Duculan, Judilyn, Gulati, Nicholas, Bonifacio, Kathleen M., Kunjravia, Norma, Zheng, Xiuzhong, Suárez-Fariñas, Mayte, Shemer, Avner, Guttman-Yassky, Emma, Krueger, James G.

“…Alopecia areata (AA) is a common inflammatory disease targeting the anagen‐stage hair follicle. Different cytokines have been implicated in the disease…”
Get full text

Aberrant connective tissue differentiation towards cartilage and bone underlies human keloids in African Americans by Fuentes‐Duculan, Judilyn, Bonifacio, Kathleen M., Suárez‐Fariñas, Mayte, Kunjravia, Norma, Garcet, Sandra, Cruz, Tristan, Wang, Claire Q. F., Xu, Hui, Gilleadeau, Patricia, Sullivan‐Whalen, Mary, Tirgan, Michael H., Krueger, James G.

“…Keloids are benign fibroproliferative tumors more frequently found among African Americans. Until now, keloid etiopathogenesis is not fully understood. To…”
Get full text

Broad defects in epidermal cornification in atopic dermatitis identified through genomic analysis by Guttman-Yassky, Emma, MD, MSc, Suárez-Fariñas, Mayte, PhD, Chiricozzi, Andrea, MD, Nograles, Kristine E., MD, Shemer, Avner, MD, Fuentes-Duculan, Judilyn, MD, Cardinale, Irma, MSc, Lin, Peng, BSc, Bergman, Reuven, MD, Bowcock, Anne M., PhD, Krueger, James G., MD, PhD

“…Background Psoriasis and atopic dermatitis (AD) are common, complex inflammatory skin diseases. Both diseases display immune infiltrates in lesions and…”
Get full text

The erythema Q‐score, an imaging biomarker for redness in skin inflammation by Frew, John, Penzi, Lauren, Suarez‐Farinas, Mayte, Garcet, Sandra, Brunner, Patrick M., Czarnowicki, Tali, Kim, Jaehwan, Bottomley, Claire, Finney, Robert, Cueto, Inna, Fuentes‐Duculan, Judilyn, Ohmatsu, Hanako, Lentini, Tim, Yanofsky, Valerie, Krueger, James G., Guttman‐Yassky, Emma, Gareau, Daniel

“…Physician rating of cutaneous erythema is central to clinical dermatological assessment as well as quantification of outcome measures in clinical trials in a…”
Get full text

Novel immune signatures associated with dysplastic naevi and primary cutaneous melanoma in human skin by Yan, Bernice Y., Garcet, Sandra, Gulati, Nicholas, Kiecker, Felix, Fuentes‐Duculan, Judilyn, Gilleaudeau, Patricia, Sullivan‐Whalen, Mary, Shemer, Avner, Mitsui, Hiroshi, Krueger, James G.

“…Dysplastic naevi (DN) are benign lesions with atypical features intermediate between that of common melanocytic naevi (CMN) and malignant melanoma (MM). Debate…”
Get full text

Progressive activation of TH2/TH22 cytokines and selective epidermal proteins characterizes acute and chronic atopic dermatitis by Gittler, Julia K., Shemer, Avner, Suárez-Fariñas, Mayte, Fuentes-Duculan, Judilyn, Gulewicz, Kara J., Wang, Claire Q.F., Mitsui, Hiroshi, Cardinale, Irma, de Guzman Strong, Cristina, Krueger, James G., Guttman-Yassky, Emma

“…Atopic dermatitis (AD) is a common disease with an increasing prevalence. The primary pathogenesis of the disease is still elusive, resulting in the lack of…”
Get full text

IL-17A inhibition by secukinumab induces early clinical, histopathologic, and molecular resolution of psoriasis by Krueger, James G., Wharton, Keith A., Schlitt, Thomas, Suprun, Maria, Torene, Rebecca I., Jiang, Xiaoyu, Wang, Claire Q., Fuentes-Duculan, Judilyn, Hartmann, Nicole, Peters, Thomas, Koroleva, Irina, Hillenbrand, Rainer, Letzkus, Martin, Yu, Xiaojing, Li, Yue, Glueck, Anton, Hasselberg, Anke, Flannery, Brian, Suárez-Fariñas, Mayte, Hueber, Wolfgang

“…Hyperactivity of the IL-23/IL-17 axis is central to plaque psoriasis pathogenesis. Secukinumab, a fully human mAb that selectively inhibits IL-17A, is approved…”
Get full text

Early-onset pediatric atopic dermatitis is TH2 but also TH17 polarized in skin by Esaki, Hitokazu, Brunner, Patrick M., Renert-Yuval, Yael, Czarnowicki, Tali, Huynh, Thy, Tran, Gary, Lyon, Sarah, Rodriguez, Giselle, Immaneni, Supriya, Johnson, Donald B., Bauer, Bruce, Fuentes-Duculan, Judilyn, Zheng, Xiuzhong, Peng, Xiangyu, Estrada, Yeriel D., Xu, Hui, de Guzman Strong, Christina, Suárez-Fariñas, Mayte, Krueger, James G., Paller, Amy S., Guttman-Yassky, Emma

“…Atopic dermatitis (AD) affects 15% to 25% of children and 4% to 7% of adults. Paradigm-shifting discoveries about AD have been based on adult biomarkers,…”
Get full text

Efficacy and safety of ustekinumab treatment in adults with moderate‐to‐severe atopic dermatitis by Khattri, Saakshi, Brunner, Patrick M., Garcet, Sandra, Finney, Robert, Cohen, Steven R., Oliva, Margeaux, Dutt, Riana, Fuentes‐Duculan, Judilyn, Zheng, Xiuzhong, Li, Xuan, Bonifacio, Kathleen M., Kunjravia, Norma, Coats, Israel, Cueto, Inna, Gilleaudeau, Patricia, Sullivan‐Whalen, Mary, Suárez‐Fariñas, Mayte, Krueger, James G., Guttman‐Yassky, Emma

“…Atopic dermatitis (AD) is the most common inflammatory skin disease, but treatment options for moderate‐to‐severe disease are limited. Ustekinumab is an…”
Get full text

Autoantigens ADAMTSL5 and LL37 are significantly upregulated in active Psoriasis and localized with keratinocytes, dendritic cells and other leukocytes by Fuentes‐Duculan, Judilyn, Bonifacio, Kathleen M., Hawkes, Jason E., Kunjravia, Norma, Cueto, Inna, Li, Xuan, Gonzalez, Juana, Garcet, Sandra, Krueger, James G.

“…Psoriasis is a common immune‐mediated disease that affects 2%‐4% of individuals in North America and Europe. In the past decade, advances in research have led…”
Get full text

Alopecia areata profiling shows TH1, TH2, and IL-23 cytokine activation without parallel TH17/TH22 skewing by Suárez-Fariñas, Mayte, Ungar, Benjamin, Noda, Shinji, Shroff, Anjali, Mansouri, Yasaman, Fuentes-Duculan, Judilyn, Czernik, Annette, Zheng, Xiuzhong, Estrada, Yeriel D., Xu, Hui, Peng, Xiangyu, Shemer, Avner, Krueger, James G., Lebwohl, Mark G., Guttman-Yassky, Emma

“…Alopecia areata (AA) is a common T cell–mediated disorder with limited therapeutics. A molecular profile of cytokine pathways in AA tissues is lacking…”
Get full text

Inflammasome Signaling and Impaired Vascular Health in Psoriasis by Garshick, Michael S, Barrett, Tessa J, Wechter, Todd, Azarchi, Sarah, Scher, Jose U, Neimann, Andrea, Katz, Stuart, Fuentes-Duculan, Judilyn, Cannizzaro, Maria V, Jelic, Sanja, Fisher, Edward A, Krueger, James G, Berger, Jeffrey S

“…OBJECTIVE—Psoriasis is an inflammatory skin disease which heightens the risk of cardiovascular disease. This study directly investigated vascular endothelial…”
Get full text

Psoriasis Is Characterized by Accumulation of Immunostimulatory and Th1/Th17 Cell-Polarizing Myeloid Dendritic Cells by Zaba, Lisa C., Fuentes-Duculan, Judilyn, Eungdamrong, Narat John, Abello, Maria Veronica, Novitskaya, Inna, Pierson, Katherine C., Gonzalez, Juana, Krueger, James G., Lowes, Michelle A.

“…Myeloid dermal dendritic cells (DCs) accumulate in chronically inflamed tissues such as psoriasis. The importance of these cells for psoriasis pathogenesis is…”
Get full text

A Novel Chimeric Lysin Shows Superiority to Mupirocin for Skin Decolonization of Methicillin-Resistant and -Sensitive Staphylococcus aureus Strains by PASTAGIA, Mina, EULER, Chad, CHAHALES, Peter, FUENTES-DUCULAN, Judilyn, KRUEGER, James G, FISCHETTI, Vincent A

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Enhancement of cutaneous immunity during aging by blocking p38 mitogen-activated protein (MAP) kinase–induced inflammation by Vukmanovic-Stejic, Milica, Chambers, Emma S., Suárez-Fariñas, Mayte, Sandhu, Daisy, Fuentes-Duculan, Judilyn, Patel, Neil, Agius, Elaine, Lacy, Katie E., Turner, Carolin T., Larbi, Anis, Birault, Veronique, Noursadeghi, Mahdad, Mabbott, Neil A., Rustin, Malcolm H.A., Krueger, James G., Akbar, Arne N.

“…Immunity decreases with age, which leads to reactivation of varicella zoster virus (VZV). In human subjects age-associated immune changes are usually measured…”
Get full text

IL-17 induces an expanded range of downstream genes in reconstituted human epidermis model by Chiricozzi, Andrea, Nograles, Kristine E, Johnson-Huang, Leanne M, Fuentes-Duculan, Judilyn, Cardinale, Irma, Bonifacio, Kathleen M, Gulati, Nicholas, Mitsui, Hiroshi, Guttman-Yassky, Emma, Suárez-Fariñas, Mayte, Krueger, James G

“…IL-17 is the defining cytokine of the Th17, Tc17, and γδ T cell populations that plays a critical role in mediating inflammation and autoimmunity. Psoriasis…”
Get full text

Tofacitinib attenuates pathologic immune pathways in patients with psoriasis: A randomized phase 2 study by Krueger, James, MD, PhD, Clark, James D., PhD, Suárez-Fariñas, Mayte, PhD, Fuentes-Duculan, Judilyn, MD, Cueto, Inna, MSc, Wang, Claire Q., PhD, Tan, Huaming, PhD, Wolk, Robert, MD, Rottinghaus, Scott T., MD, Whitley, Maryann Z., DSc, Valdez, Hernan, MD, von Schack, David, PhD, O'Neil, Shawn P., DVM, PhD, Reddy, Padmalatha S., PhD, Tatulych, Svitlana, MD

“…Background Tofacitinib is an oral Janus kinase inhibitor being investigated for psoriasis. Objective We sought to elucidate the molecular mechanisms underlying…”
Get full text

Cutting Edge: Selective Oral ROCK2 Inhibitor Reduces Clinical Scores in Patients with Psoriasis Vulgaris and Normalizes Skin Pathology via Concurrent Regulation of IL-17 and IL-10 by Zanin-Zhorov, Alexandra, Weiss, Jonathan M, Trzeciak, Alissa, Chen, Wei, Zhang, Jingya, Nyuydzefe, Melanie S, Arencibia, Carmen, Polimera, Seetharam, Schueller, Olivier, Fuentes-Duculan, Judilyn, Bonifacio, Kathleen M, Kunjravia, Norma, Cueto, Inna, Soung, Jennifer, Fleischmann, Roy M, Kivitz, Alan, Lebwohl, Mark, Nunez, Margarita, Woodson, Johnnie, Smith, Shondra L, West, Robert F, Berger, Mark, Krueger, James G, Ryan, John L, Waksal, Samuel D

“…Targeted inhibition of Rho-associated kinase (ROCK)2 downregulates the proinflammatory T cell response while increasing the regulatory arm of the immune…”
Get full text