Search Results - "Fuentes, Sherezade"
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Priming human adipose‐derived mesenchymal stem cells for corneal surface regeneration
Published in Journal of cellular and molecular medicine (01-06-2021)“…Limbal stem cells (LSC) maintain the transparency of the corneal epithelium. Chemical burns lead the loss of LSC inducing an up‐regulation of pro‐inflammatory…”
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Treatment of corneal endothelial damage in a rabbit model with a bioengineered graft using human decellularized corneal lamina and cultured human corneal endothelium
Published in PloS one (21-11-2019)“…We aimed to investigate the functionality of human decellularized stromal laminas seeded with cultured human corneal endothelial cells as a tissue engineered…”
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Adipose-derived mesenchymal stem cell administration does not improve corneal graft survival outcome
Published in PloS one (02-03-2015)“…The effect of local and systemic injections of mesenchymal stem cells derived from adipose tissue (AD-MSC) into rabbit models of corneal allograft rejection…”
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Exploring cognitive and biological correlates of sleep quality and their potential links with Alzheimer's disease (ALFASleep project): protocol for an observational study
Published in BMJ open (30-12-2022)“…The growing worldwide prevalence of Alzheimer's disease (AD) and the lack of effective treatments pose a dire medical challenge. Sleep disruption is also…”
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Subjective cognitive decline and anxious/depressive symptoms during the COVID-19 pandemic: what is the role of stress perception, stress resilience, and β-amyloid?
Published in Alzheimer's research & therapy (06-09-2022)“…The COVID-19 pandemic may worsen the mental health of people reporting subjective cognitive decline (SCD) and therefore their clinical prognosis. We aimed to…”
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Sex, caregiver status and amyloid positivity predict increased anxiety and depression during the COVID‐19‒related confinement
Published in Alzheimer's & dementia (01-12-2021)“…Background Anxiety and depression are more prevalent in women and caregivers and are associated with increased Alzheimer’s disease (AD) risk. We investigated…”
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Cornea and ocular surface treatment
Published in Current stem cell research & therapy (01-06-2010)“…In addition to being a protective shield, the cornea represents two thirds of the eye's refractive power. Corneal pathology can affect one or all of the…”
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Differences Between Plasma and Cerebrospinal Fluid Glial Fibrillary Acidic Protein Levels Across the Alzheimer Disease Continuum
Published in JAMA neurology (01-12-2021)“…Glial fibrillary acidic protein (GFAP) is a marker of reactive astrogliosis that increases in the cerebrospinal fluid (CSF) and blood of individuals with…”
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Novel tau biomarkers phosphorylated at T181, T217 or T231 rise in the initial stages of the preclinical Alzheimer’s continuum when only subtle changes in Aβ pathology are detected
Published in EMBO molecular medicine (07-12-2020)“…In Alzheimer’s disease (AD), tau phosphorylation in the brain and its subsequent release into cerebrospinal fluid (CSF) and blood is a dynamic process that…”
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Pluripotent Stem Cells: Origin, Maintenance and Induction
Published in Stem cell reviews (01-12-2010)“…Pluripotency is defined as the potential of a cell to differentiate into cells of the three germ layers: endoderm, mesoderm and ectoderm. In vivo, the presence…”
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CSF Synaptic Biomarkers in the Preclinical Stage of Alzheimer Disease and Their Association With MRI and PET: A Cross-sectional Study
Published in Neurology (23-11-2021)“…To determine whether CSF synaptic biomarkers are altered in the early preclinical stage of the Alzheimer continuum and associated with Alzheimer disease (AD)…”
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Sex/gender effects of glial reactivity on preclinical Alzheimer's disease pathology
Published in Molecular psychiatry (09-10-2024)“…Glial reactivity may contribute to sex/gender differences in Alzheimer's disease (AD) pathophysiology. Here, we investigated the differential effect of…”
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Lifetime Stressful Events Associated with Alzheimer's Pathologies, Neuroinflammation and Brain Structure in a Risk Enriched Cohort
Published in Annals of neurology (01-06-2024)“…Objective Along with the known effects of stress on brain structure and inflammatory processes, increasing evidence suggest a role of chronic stress in the…”
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Genotypic effects of APOE-ε4 on resting-state connectivity in cognitively intact individuals support functional brain compensation
Published in Cerebral cortex (New York, N.Y. 1991) (10-03-2023)“…Abstract The investigation of resting-state functional connectivity (rsFC) in asymptomatic individuals at genetic risk for Alzheimer’s disease (AD) enables…”
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Age, sex and APOE-ε4 modify the balance between soluble and fibrillar β-amyloid in non-demented individuals: topographical patterns across two independent cohorts
Published in Molecular psychiatry (01-04-2022)“…Amyloid (Aβ) pathology is the earliest detectable pathophysiological event along the Alzheimer’s continuum , which can be measured both in the cerebrospinal…”
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Perivascular spaces are associated with tau pathophysiology and synaptic dysfunction in early Alzheimer’s continuum
Published in Alzheimer's research & therapy (05-08-2021)“…Abstract Background Perivascular spaces (PVS) have an important role in the elimination of metabolic waste from the brain. It has been hypothesized that the…”
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Genetically predicted telomere length and Alzheimer's disease endophenotypes: a Mendelian randomization study
Published in Alzheimer's research & therapy (07-11-2022)“…Telomere length (TL) is associated with biological aging, consequently influencing the risk of age-related diseases such as Alzheimer's disease (AD). We aimed…”
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Association of weight change with cerebrospinal fluid biomarkers and amyloid positron emission tomography in preclinical Alzheimer's disease
Published in Alzheimer's research & therapy (17-02-2021)“…Recognizing clinical manifestations heralding the development of Alzheimer's disease (AD)-related cognitive impairment could improve the identification of…”
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APOE-ε4 modulates the association between regional amyloid deposition and cognitive performance in cognitively unimpaired middle-aged individuals
Published in EJNMMI research (01-03-2023)“…Purpose To determine whether the APOE-ε4 allele modulates the relationship between regional β-amyloid (Aβ) accumulation and cognitive change in middle-aged…”
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Brain alterations in the early Alzheimer’s continuum with amyloid-β, tau, glial and neurodegeneration CSF markers
Published in Brain communications (2022)“…Abstract Higher grey matter volumes/cortical thickness and fluorodeoxyglucose uptake have been consistently found in cognitively unimpaired individuals with…”
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