Search Results - "Fuchs‐Young, Robin"
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Culture of Tumorigenic Cells on Protein Fibers Reveals Metastatic Cell Behaviors
Published in Biomacromolecules (14-11-2016)“…Tumorigenic cell behaviors can be suppressed or enhanced by their physicochemical environment. As a first step toward developing materials that allow…”
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Overexpression of IGF-1 During Early Development Expands the Number of Mammary Stem Cells and Primes them for Transformation
Published in Stem cells (Dayton, Ohio) (31-03-2022)“…Insulin-like growth factor I (IGF-1) has been implicated in breast cancer due to its mitogenic and anti-apoptotic effects. Despite substantial research on the…”
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Dynamic role of the codon 72 p53 single-nucleotide polymorphism in mammary tumorigenesis in a humanized mouse model
Published in Oncogene (01-05-2019)“…Female breast cancer (BrCa) is the most common noncutaneous cancer among women in the United States. Human epidemiological studies reveal that a p53…”
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Early Dietary Exposures Epigenetically Program Mammary Cancer Susceptibility through Igf1-Mediated Expansion of the Mammary Stem Cell Compartment
Published in Cells (Basel, Switzerland) (01-08-2022)“…Diet is a critical environmental factor affecting breast cancer risk, and recent evidence shows that dietary exposures during early development can affect…”
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Short-Term Training with Basic Science Research Literature Advances Medical Students' Skills for Adaptive Expertise
Published in Journal of medical education and curricular development (01-01-2024)“…Physicians must adapt their learning and expertise to the rapid evolution of healthcare. To train for the innovation-efficient demands of adaptive expertise,…”
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Transgenic insulin-like growth factor-1 stimulates activation of COX-2 signaling in mammary glands
Published in Molecular carcinogenesis (01-12-2012)“…Studies show that elevated insulin‐like growth factor‐1 (IGF‐1) levels are associated with an increased risk of breast cancer; however, mechanisms through…”
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Addressing cancer health disparities using a global biopsychosocial approach
Published in Cancer (15-01-2010)“…The Center for Research on Minority Health has translated the biopsychosocial framework to address global cancer health disparities through the integration of…”
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Altered Hormonal Responsiveness of Proliferation and Apoptosis During Myometrial Maturation and the Development of Uterine Leiomyomas in the Rat
Published in Biology of reproduction (01-11-2000)“…Uterine leiomyomas are responsive to the ovarian steroids, estrogen and progesterone; however, a mechanistic understanding of the role of these hormones in the…”
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Inhibition of estrogen-stimulated growth of uterine leiomyomas by selective estrogen receptor modulators
Published in Molecular carcinogenesis (01-11-1996)“…Uterine leiomyoma is the most frequent gynecologic neoplasm in women. By using a panel of cell lines derived from spontaneous Eker rat leiomyomas, we examined…”
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Influence of Exogenous Estrogen Receptor Ligands on Uterine Leiomyoma: Evidence from an in Vitro/in Vivo Animal Model for Uterine Fibroids
Published in Environmental health perspectives (01-10-2000)“…The remarkable frequency of uterine leiomyoma in the human population calls into question the potential for the participation of environmental factors in tumor…”
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An in vivo/in vitro Model to Assess Endocrine Disrupting Activity of Xenoestrogens in Uterine Leiomyoma
Published in Annals of the New York Academy of Sciences (01-12-2001)“…: Xenoestrogens with endocrine disrupting activity have been associated with the dysregulation of reproductive function and promotion of malignancies in…”
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Differential susceptibility to chemically induced thymic lymphomas in SENCARB and SSIN inbred mice
Published in Molecular carcinogenesis (01-07-2006)“…In the past 20 yr, several inbred strains have been derived from SENCAR outbred mice. These strains display different susceptibility to the induction of…”
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Multi-directional communication between decision makers and environmental health researchers: a qualitative inquiry
Published in Environmental hazards (26-05-2024)“…It has been three decades since key leaders gathered to pave a path toward healthier and more just environments and recommendations were made to improve…”
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Guiding Preclinical Medical Students in Finding, Synthesizing, and Communicating Translational Basic Research Literature: Roles for Basic Science Research Mentors
Published in Academic medicine (01-05-2022)“…Understanding and communicating medical advances driven by basic research, and acquiring foundational skills in critically appraising and communicating…”
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Transcriptional Regulation of Estrogen Receptor-α by p53 in Human Breast Cancer Cells
Published in Cancer research (Chicago, Ill.) (15-04-2009)“…Estrogen receptor alpha (ER) and p53 are critical prognostic indicators in breast cancer. Loss of functional p53 is correlated with poor prognosis, ER…”
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The Importance Of Accurate Measurements In Voluntary Wheel Running In Mice: 3665 Board #112 June 3 8 00 AM - 9 30 AM
Published in Medicine and science in sports and exercise (01-05-2017)Get full text
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Early Exposure to a High Fat/High Sugar Diet Increases the Mammary Stem Cell Compartment and Mammary Tumor Risk in Female Mice
Published in Cancer prevention research (Philadelphia, Pa.) (01-10-2017)“…Obesity and alterations in metabolic programming from early diet exposures can affect the propensity to disease in later life. Through dietary manipulation,…”
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