Search Results - "Fuchs, Tobias"

Neutrophil Extracellular Trap (NET) Impact on Deep Vein Thrombosis by Fuchs, Tobias A, Brill, Alexander, Wagner, Denisa D

“…Deep vein thrombosis (DVT) is a major health problem that requires improved prophylaxis and treatment. Inflammatory conditions such as infection, cancer, and…”
Get full text

Histones induce rapid and profound thrombocytopenia in mice by Fuchs, Tobias A., Bhandari, Ashish A., Wagner, Denisa D.

“…Histones are released from dying cells and contribute to antimicrobial defense during infection. However, extracellular histones are a double-edged sword…”
Get full text

Circulating Extracellular DNA: Cause or Consequence of Thrombosis? by Jiménez-Alcázar, Miguel, Kim, Natalie, Fuchs, Tobias A

“…Thrombosis leads to ischemic organ damage in cardiovascular and thromboembolic diseases. Neutrophils promote thrombosis in vitro and in vivo by releasing…”
Get more information

Heme-induced neutrophil extracellular traps contribute to the pathogenesis of sickle cell disease by Chen, Grace, Zhang, Dachuan, Fuchs, Tobias A., Manwani, Deepa, Wagner, Denisa D., Frenette, Paul S.

“…Sickle cell disease (SCD) is characterized by recurring episodes of vascular occlusion in which neutrophil activation plays a major role. The disease is…”
Get full text

Activation of the Raf-MEK-ERK pathway is required for neutrophil extracellular trap formation by Zychlinsky, Arturo, Waldmann, Herbert, Hakkim, Abdul, Fuchs, Tobias A, Martinez, Nancy E, Hess, Simone, Prinz, Heino

“…The signaling mechanisms leading to the formation of neutrophil extracellular traps (NETs), relevant in infections, sepsis and autoimmune diseases, are poorly…”
Get full text

Cancers predispose neutrophils to release extracellular DNA traps that contribute to cancer-associated thrombosis by Demers, Mélanie, Krause, Daniela S, Schatzberg, Daphne, Martinod, Kimberly, Voorhees, Jaymie R, Fuchs, Tobias A, Scadden, David T, Wagner, Denisa D

“…Cancer-associated thrombosis often lacks a clear etiology. However, it is linked to a poor prognosis and represents the second-leading cause of death in cancer…”
Get full text

Neutrophil histone modification by peptidylarginine deiminase 4 is critical for deep vein thrombosis in mice by Martinod, Kimberly, Demers, Melanie, Fuchs, Tobias A., Wong, Siu Ling, Brill, Alexander, Gallant, Maureen, Hu, Jing, Wang, Yanming, Wagner, Denisa D.

“…Deep vein thrombosis and pulmonary embolism are major health problems associated with high mortality. Recently, DNA-based neutrophil extracellular traps (NETs)…”
Get full text

Host DNases prevent vascular occlusion by neutrophil extracellular traps by Jiménez-Alcázar, Miguel, Rangaswamy, Chandini, Panda, Rachita, Bitterling, Josephine, Simsek, Yashin J., Long, Andy T., Bilyy, Rostyslav, Krenn, Veit, Renné, Christoph, Renné, Thomas, Kluge, Stefan, Panzer, Ulf, Mizuta, Ryushin, Mannherz, Hans Georg, Kitamura, Daisuke, Herrmann, Martin, Napirei, Markus, Fuchs, Tobias A.

“…Platelet and fibrin clots occlude blood vessels in hemostasis and thrombosis. Here we report a noncanonical mechanism for vascular occlusion based on…”
Get full text

Extracellular DNA traps promote thrombosis by Fuchs, Tobias A., Brill, Alexander, Duerschmied, Daniel, Schatzberg, Daphne, Monestier, Marc, Myers, Daniel D., Wrobleski, Shirley K., Wakefield, Thomas W., Hartwig, John H., Wagner, Denisa D.

“…Neutrophil extracellular traps (NETs) are part of the innate immune response to infections. NETs are a meshwork of DNA fibers comprising histones and…”
Get full text

Novel cell death program leads to neutrophil extracellular traps by Fuchs, Tobias A, Abed, Ulrike, Goosmann, Christian, Hurwitz, Robert, Schulze, Ilka, Wahn, Volker, Weinrauch, Yvette, Brinkmann, Volker, Zychlinsky, Arturo

“…Neutrophil extracellular traps (NETs) are extracellular structures composed of chromatin and granule proteins that bind and kill microorganisms. We show that…”
Get full text

Myeloperoxidase is required for neutrophil extracellular trap formation: implications for innate immunity by Metzler, Kathleen D., Fuchs, Tobias A., Nauseef, William M., Reumaux, Dominique, Roesler, Joachim, Schulze, Ilka, Wahn, Volker, Papayannopoulos, Venizelos, Zychlinsky, Arturo

“…The granule enzyme myeloperoxidase (MPO) plays an important role in neutrophil antimicrobial responses. However, the severity of immunodeficiency in patients…”
Get full text

Factor XII as a Therapeutic Target in Thromboembolic and Inflammatory Diseases by Nickel, Katrin F, Long, Andy T, Fuchs, Tobias A, Butler, Lynn M, Renné, Thomas

“…Coagulation factor XII (FXII, Hageman factor) is a plasma protease that in its active form (FXIIa) initiates the procoagulant and proinflammatory contact…”
Get full text

PAD4-deficiency does not affect bacteremia in polymicrobial sepsis and ameliorates endotoxemic shock by Martinod, Kimberly, Fuchs, Tobias A., Zitomersky, Naamah L., Wong, Siu Ling, Demers, Melanie, Gallant, Maureen, Wang, Yanming, Wagner, Denisa D.

“…Neutrophil extracellular traps (NETs), consisting of nuclear DNA with histones and microbicidal proteins, are expelled from activated neutrophils during…”
Get full text

Validation of deep-learning image reconstruction for coronary computed tomography angiography: Impact on noise, image quality and diagnostic accuracy by Benz, Dominik C., Benetos, Georgios, Rampidis, Georgios, von Felten, Elia, Bakula, Adam, Sustar, Aleksandra, Kudura, Ken, Messerli, Michael, Fuchs, Tobias A., Gebhard, Catherine, Pazhenkottil, Aju P., Kaufmann, Philipp A., Buechel, Ronny R.

“…Advances in image reconstruction are necessary to decrease radiation exposure from coronary CT angiography (CCTA) further, but iterative reconstruction has…”
Get full text

von Willebrand factor–mediated platelet adhesion is critical for deep vein thrombosis in mouse models by Brill, Alexander, Fuchs, Tobias A., Chauhan, Anil K., Yang, Janie J., De Meyer, Simon F., Köllnberger, Maria, Wakefield, Thomas W., Lämmle, Bernhard, Massberg, Steffen, Wagner, Denisa D.

“…Deep vein thrombosis (DVT) and its complication, pulmonary embolism, are frequent causes of disability and mortality. Although blood flow disturbance is…”
Get full text

Extracellular Chromatin Is an Important Mediator of Ischemic Stroke in Mice by De Meyer, Simon F, Suidan, Georgette L, Fuchs, Tobias A, Monestier, Marc, Wagner, Denisa D

“…OBJECTIVE—Recently, a growing number of studies have revealed a prothrombotic and cytotoxic role for extracellular chromatin. Cerebral ischemia/reperfusion…”
Get full text

Circulating DNA and myeloperoxidase indicate disease activity in patients with thrombotic microangiopathies by Fuchs, Tobias A., Kremer Hovinga, Johanna A., Schatzberg, Daphne, Wagner, Denisa D., Lämmle, Bernhard

“…Thrombotic microangiopathies (TMAs) are a group of life-threatening disorders characterized by thrombocytopenia, fragmentation of erythrocytes, and ischemic…”
Get full text

Neutrophil Extracellular Traps Initiate Gallstone Formation by Muñoz, Luis E., Boeltz, Sebastian, Bilyy, Rostyslav, Schauer, Christine, Mahajan, Aparna, Widulin, Navena, Grüneboom, Anika, Herrmann, Irmgard, Boada, Edgyda, Rauh, Manfred, Krenn, Veit, Biermann, Mona H.C., Podolska, Malgorzata J., Hahn, Jonas, Knopf, Jasmin, Maueröder, Christian, Paryzhak, Solomiya, Dumych, Tetiana, Zhao, Yi, Neurath, Markus F., Hoffmann, Markus H., Fuchs, Tobias A., Leppkes, Moritz, Schett, Georg, Herrmann, Martin

“…The presence of gallstones (cholelithiasis) is a highly prevalent and severe disease and one of the leading causes of hospital admissions worldwide. Due to its…”
Get full text

The polyphosphate–factor XII pathway drives coagulation in prostate cancer-associated thrombosis by Nickel, Katrin F., Ronquist, Göran, Langer, Florian, Labberton, Linda, Fuchs, Tobias A., Bokemeyer, Carsten, Sauter, Guido, Graefen, Markus, Mackman, Nigel, Stavrou, Evi X., Ronquist, Gunnar, Renné, Thomas

“…Cancer is a leading cause of thrombosis. We identify a new procoagulant mechanism that contributes to thromboembolism in prostate cancer and allows for safe…”
Get full text

Elevated Levels of Circulating DNA and Chromatin Are Independently Associated With Severe Coronary Atherosclerosis and a Prothrombotic State by Borissoff, Julian I, Joosen, Ivo A, Versteylen, Mathijs O, Brill, Alexander, Fuchs, Tobias A, Savchenko, Alexander S, Gallant, Maureen, Martinod, Kimberly, ten Cate, Hugo, Hofstra, Leonard, Crijns, Harry J, Wagner, Denisa D, Kietselaer, Bas L.J.H

“…OBJECTIVE—Aberrant neutrophil activation occurs during the advanced stages of atherosclerosis. Once primed, neutrophils can undergo apoptosis or release…”
Get full text