Search Results - "Fuchs, Margit"

Identification of the key structural motifs involved in HspB8/HspB6-Bag3 interaction by Fuchs, Margit, Poirier, Dominic J, Seguin, Samuel J, Lambert, Herman, Carra, Serena, Charette, Steve J, Landry, Jacques

“…The molecular chaperone HspB8 [Hsp (heat-shock protein) B8] is member of the B-group of Hsps. These proteins bind to unfolded or misfolded proteins and protect…”
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A Role for the Chaperone Complex BAG3-HSPB8 in Actin Dynamics, Spindle Orientation and Proper Chromosome Segregation during Mitosis by Fuchs, Margit, Luthold, Carole, Guilbert, Solenn M, Varlet, Alice Anaïs, Lambert, Herman, Jetté, Alexandra, Elowe, Sabine, Landry, Jacques, Lavoie, Josée N

“…The co-chaperone BAG3, in complex with the heat shock protein HSPB8, plays a role in protein quality control during mechanical strain. It is part of a…”
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CDK1-Mediated Phosphorylation of BAG3 Promotes Mitotic Cell Shape Remodeling and the Molecular Assembly of Mitotic p62 Bodies by Luthold, Carole, Lambert, Herman, Guilbert, Solenn M, Rodrigue, Marc-Antoine, Fuchs, Margit, Varlet, Alice-Anaïs, Fradet-Turcotte, Amélie, Lavoie, Josée N

“…The cochaperone BCL2-associated athanogene 3 (BAG3), in complex with the heat shock protein HSPB8, facilitates mitotic rounding, spindle orientation, and…”
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HSPB8 and BAG3 cooperate to promote spatial sequestration of ubiquitinated proteins and coordinate the cellular adaptive response to proteasome insufficiency by Guilbert, Solenn M., Lambert, Herman, Rodrigue, Marc‐Antoine, Fuchs, Margit, Landry, Jacques, Lavoie, Josée N.

“…BCL2‐associated athanogene (BAG)‐3 is viewed as a platform that would physically and functionally link distinct classes of molecular chaperones of the heat…”
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Predictors of Clostridioides difficile Infection Among Asymptomatic, Colonized Patients: A Retrospective Cohort Study by Poirier, Dominic, Gervais, Philippe, Fuchs, Margit, Roussy, Jean-Francois, Paquet-Bolduc, Bianka, Trottier, Sylvie, Longtin, Jean, Loo, Vivian G, Longtin, Yves

“…Asymptomatic patients colonized with Clostridioides difficile are at risk of developing C. difficile infection (CDI), but the factors associated with disease…”
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Metformin rescues muscle function in BAG3 myofibrillar myopathy models by Ruparelia, Avnika A., McKaige, Emily A., Williams, Caitlin, Schulze, Keith E., Fuchs, Margit, Oorschot, Viola, Lacene, Emmanuelle, Meregalli, Mirella, Lee, Clara, Serrano, Rita J., Baxter, Emily C., Monro, Keyne, Torrente, Yvan, Ramm, Georg, Stojkovic, Tanya, Lavoie, Josée N., Bryson-Richardson, Robert J.

“…Dominant de novo mutations in the co-chaperone BAG3 cause a severe form of myofibrillar myopathy, exhibiting progressive muscle weakness, muscle structural…”
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Patients' perspectives and safety of COVID-19 vaccination among cancer patients: A prospective single-center study by Daaboul, Nathalie, Boutin, Melina, Sperlich, Catherine, Fuchs, Margit, Haraoui, Louis-Patrick, Speranza, Giovanna, Nguyen, Nghia T Trung, De Angelis, Flavia, Martel, Samuel, Soldera, Sara V., Trudel, Sabrina, Desjardins, Pierre, Srour, Line, Samson, Benoit, Fox, Susan, Devaux, Celine, Prady, Catherine

“…e24043 Background: Concerns about safety and treatment interference are known barriers to COVID-19 vaccination in cancer patients. Data on safety and…”
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Fine-tuning of actin dynamics by the HSPB8-BAG3 chaperone complex facilitates cytokinesis and contributes to its impact on cell division by Varlet, Alice Anaïs, Fuchs, Margit, Luthold, Carole, Lambert, Herman, Landry, Jacques, Lavoie, Josée N.

“…The small heat shock protein HSPB8 and its co-chaperone BAG3 are proposed to regulate cytoskeletal proteostasis in response to mechanical signaling in muscle…”
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Adenoviral protein E4orf4 interacts with the polarity protein Par3 to induce nuclear rupture and tumor cell death by Dziengelewski, Claire, Rodrigue, Marc-Antoine, Caillier, Alexia, Jacquet, Kévin, Boulanger, Marie-Chloé, Bergeman, Jonathan, Fuchs, Margit, Lambert, Herman, Laprise, Patrick, Richard, Darren E, Bordeleau, François, Huot, Marc-Étienne, Lavoie, Josée N

“…The tumor cell-selective killing activity of the adenovirus type 2 early region 4 ORF4 (E4orf4) protein is poorly defined at the molecular level. Here, we show…”
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A functional interplay between the small GTPase Rab11a and mitochondria-shaping proteins regulates mitochondrial positioning and polarization of the actin cytoskeleton downstream of Src family kinases by Landry, Marie-Claude, Champagne, Claudia, Boulanger, Marie-Chloé, Jetté, Alexandra, Fuchs, Margit, Dziengelewski, Claire, Lavoie, Josée N

“…It is believed that mitochondrial dynamics is coordinated with endosomal traffic rates during cytoskeletal remodeling, but the mechanisms involved are largely…”
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Adenofection: A Method for Studying the Role of Molecular Chaperones in Cellular Morphodynamics by Depletion-Rescue Experiments by Fuchs, Margit, Boulanger, Marie-Chloé, Lambert, Herman, Landry, Jacques, Lavoie, Josée N.

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A Functional Interplay between the Small GTPase Rab11a and Mitochondria-shaping Proteins Regulates Mitochondrial Positioning and Polarization of the Actin Cytoskeleton Downstream of Src Family KinasesThis work was supported in part by Canadian Institutes of Health Research Operating Grant MOP-49450 (to J. N. L.) and by the Natural Sciences and Engineering Research Council Grant RF:RGPIN371663 (to J. N. L.).▪▪This article contains supplemental Movie by Landry, Marie-Claude, Champagne, Claudia, Boulanger, Marie-Chloé, Jetté, Alexandra, Fuchs, Margit, Dziengelewski, Claire, Lavoie, Josée N.

“…It is believed that mitochondrial dynamics is coordinated with endosomal traffic rates during cytoskeletal remodeling, but the mechanisms involved are largely…”
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Rac1 and Rho contribute to the migratory and invasive phenotype associated with somatic E-cadherin mutation by Deplazes, Joëlle, Fuchs, Margit, Rauser, Sandra, Genth, Harald, Lengyel, Ernst, Busch, Raymonde, Luber, Birgit

“…Recent evidence suggests a close association between extracellular E-cadherin mutation in diffuse-type gastric carcinoma and the acquisition of a migratory…”
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495. Predictors of C. difficile Infection and Impact of Primary Prophylaxis Among Asymptomatic C. difficile Colonized Patients: A Cross-Sectional Study by Poirier, Dominic, Gervais, Philippe, Fuchs, Margit, Roussy, Jean-Francois, Paquet-Bolduc, Bianka, Trottier, Sylvie, Longtin, Jean, Loo, Vivian, Longtin, Yves

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Adenofection: A Method for Studying the Role of Molecular Chaperones in Cellular Morphodynamics by Depletion-Rescue Experiments by Fuchs, Margit, Boulanger, Marie-Chloé, Lambert, Herman, Landry, Jacques, Lavoie, Josée N

“…Cellular processes such as mitosis and cell differentiation are governed by changes in cell shape that largely rely on proper remodeling of the cell…”
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A Role for the Chaperone Complex BAG3-HSPB8 in Actin Dynamics, Spindle Orientation and Proper Chromosome Segregation during Mitosis: e1005582 by Fuchs, Margit, Luthold, Carole, Guilbert, Solenn M, Varlet, Alice Anaïs, Lambert, Herman, Jetté, Alexandra, Elowe, Sabine, Landry, Jacques, Lavoie, Josée N

“…The co-chaperone BAG3, in complex with the heat shock protein HSPB8, plays a role in protein quality control during mechanical strain. It is part of a…”
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Enhanced Activation of Epidermal Growth Factor Receptor Caused by Tumor-Derived E-Cadherin Mutations by BREMM, Anja, WALCH, Axel, HANN VON WEYHERN, Claus, HÖFLER, Heinz, LUBER, Birgit, FUCHS, Margit, MAGES, Jörg, DUYSTER, Justus, KELLER, Gisela, HERMANNSTÄDTER, Christine, BECKER, Karl-Friedrich, RAUSER, Sandra, LANGER, Rupert

“…Mutations of the tumor suppressor E-cadherin and overexpression of the receptor tyrosine kinase epidermal growth factor receptor (EGFR) are among the most…”
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Deletion of exon 8 increases cisplatin-induced E-cadherin cleavage by Fuchs, Margit, Hermannstädter, Christine, Hutzler, Peter, Häcker, Georg, Haller, Ferdinand, Höfler, Heinz, Luber, Birgit

“…E-Cadherin-mediated cell–cell adhesion plays a key role in epithelial cell survival and loss of E-cadherin or β-catenin expression is associated with invasive…”
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Effect of tumor-associated mutant E-cadherin variants with defects in exons 8 or 9 on matrix metalloproteinase 3 by Fuchs, Margit, Hermannstädter, Christine, Specht, Katja, Knyazev, Pjotr, Ullrich, Axel, Rosivatz, Erika, Busch, Raymonde, Hutzler, Peter, Höfler, Heinz, Luber, Birgit

“…Tumor progression is characterized by loss of cell adhesion and increase of invasion and metastasis. The cell adhesion molecule E‐cadherin is frequently…”
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Influence of tumor-associated E-cadherin mutations on tumorigenicity and metastasis by Kremer, Marcus, Quintanilla-Martinez, Leticia, Fuchs, Margit, Gamboa-Dominguez, Armando, Haye, Sieglinde, Kalthoff, Holger, Rosivatz, Erika, Hermannstädter, Christine, Busch, Raymonde, Höfler, Heinz, Luber, Birgit

“…In this study, we investigated whether tumor-associated E-cadherin mutations impair the tumor-suppressive function of the cell adhesion molecule and influence…”
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