Search Results - "Fuchs, Hazel L. S."

Synthetic studies on the tetrasubstituted D-ring of cystobactamids lead to potent terephthalic acid antibiotics by Stappert, Moritz, Kohnhäuser, Daniel, Seedorf, Tim, Coetzee, Janetta, Rox, Katharina, Fuchs, Hazel L. S., Cirnski, Katarina, Leitner, Christian, Herrmann, Jennifer, Kirschning, Andreas, Müller, Rolf, Brönstrup, Mark

“…Novel scaffolds for broad-spectrum antibiotics are rare and in strong demand because of the increase in antimicrobial resistance. The cystobactamids,…”
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Tetrazine-induced activation of a trimethyl lock as a click-to-release system for protected doxorubicin by Friederich, Julia, Xu, Chunfa, Raunft, Patrick, Fuchs, Hazel L S, Brönstrup, Mark

“…We herein report a novel chemically triggered click-to-release system, that combines the trimethyl lock (TML) lactonization with the bioorthogonal inverse…”
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Total synthesis and mechanism of action of the antibiotic armeniaspirol A by Arisetti, Nanaji, Fuchs, Hazel L. S, Coetzee, Janetta, Orozco, Manuel, Ruppelt, Dominik, Bauer, Armin, Heimann, Dominik, Kuhnert, Eric, Bhamidimarri, Satya P, Bafna, Jayesh A, Hinkelmann, Bettina, Eckel, Konstantin, Sieber, Stephan A, Müller, Peter P, Herrmann, Jennifer, Müller, Rolf, Winterhalter, Mathias, Steinem, Claudia, Brönstrup, Mark

“…Emerging antimicrobial resistance urges the discovery of antibiotics with unexplored, resistance-breaking mechanisms. Armeniaspirols represent a novel class of…”
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Polysialylation at Early Stages of Oligodendrocyte Differentiation Promotes Myelin Repair by Werneburg, Sebastian, Fuchs, Hazel L S, Albers, Iris, Burkhardt, Hannelore, Gudi, Viktoria, Skripuletz, Thomas, Stangel, Martin, Gerardy-Schahn, Rita, Hildebrandt, Herbert

“…Polysialic acid is a glycan modification of the neural cell adhesion molecule (NCAM) produced by the polysialyltransferases ST8SIA2 and ST8SIA4. Polysialic…”
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Engineering the product profile of a polysialyltransferase by Keys, Timothy G, Fuchs, Hazel L S, Ehrit, Jörg, Alves, Jürgen, Freiberger, Friedrich, Gerardy-Schahn, Rita

“…Functional assessments and applications of polysaccharides are hampered by broad product distributions. Neutral drift libraries now identify specific amino…”
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Total Synthesis of Acanthodoral Using a Rearrangement Strategy by Eggert, Alina, Schuppe, Karl T., Fuchs, Hazel L. S., Brönstrup, Mark, Kalesse, Markus

“…We present the second total synthesis of (±)-acanthodoral, a sesquiterpenoid derived from the marine nudibranch Acanthodoris nanaimoensis. Our approach…”
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Siderophore conjugation with cleavable linkers boosts the potency of RNA polymerase inhibitors against multidrug-resistant E. coli by Peukert, Carsten, Vetter, Anna C, Fuchs, Hazel L S, Harmrolfs, Kirsten, Karge, Bianka, Stadler, Marc, Brönstrup, Mark

“…The growing antibiotic resistance, foremost in Gram-negative bacteria, requires novel therapeutic approaches. We aimed to enhance the potency of…”
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A single amino acid toggles Escherichia coli polysialyltransferases between mono- and bifunctionality by Keys, Timothy G, Fuchs, Hazel L S, Galuska, Sebastian P, Gerardy-Schahn, Rita, Freiberger, Friedrich

“…The enteropathogenic Escherichia coli K92 synthesizes a unique capsule consisting of polysialic acid (polySia) with alternating α2,8- and α2,9-linkages. The…”
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Siderophore conjugation with cleavable linkers boosts the potency of RNA polymerase inhibitors against multidrug-resistant by Peukert, Carsten, Vetter, Anna C, Fuchs, Hazel L. S, Harmrolfs, Kirsten, Karge, Bianka, Stadler, Marc, Brönstrup, Mark

“…The growing antibiotic resistance, foremost in Gram-negative bacteria, requires novel therapeutic approaches. We aimed to enhance the potency of…”
Get full text