Search Results - "Fucci, Livia"
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The β-adrenergic receptor antagonist propranolol offsets resistance mechanisms to chemotherapeutics in diverse sarcoma subtypes: a pilot study
Published in Scientific reports (26-06-2020)“…Standard chemotherapy for soft tissue sarcomas has shown limited efficacy. Here, we sought to evaluate whether β-adrenergic receptor (β-AR) signalling…”
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A deep learning model based on whole slide images to predict disease-free survival in cutaneous melanoma patients
Published in Scientific reports (27-11-2022)“…The application of deep learning on whole-slide histological images (WSIs) can reveal insights for clinical and basic tumor science investigations. Finding…”
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Circulating extracellular vesicles are monitoring biomarkers of anti-PD1 response and enhancer of tumor progression and immunosuppression in metastatic melanoma
Published in Journal of experimental & clinical cancer research (28-09-2023)“…Abstract Background Clinical drawback in checkpoint inhibitors immunotherapy (ICI) of metastatic melanoma (MM) is monitoring clinical benefit. Soluble forms of…”
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Case report: Is severe toxicity the price to pay for high sensitivity to checkpoint inhibitors immunotherapy in desmoplastic melanoma?
Published in Frontiers in immunology (10-05-2024)“…Desmoplastic melanoma (DM) is a rare subtype of melanoma characterized by high immunogenicity which makes it particularly suitable for immune checkpoint…”
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Cellular analysis of bronchoalveolar lavage fluid to narrow differential diagnosis of checkpoint inhibitor-related pneumonitis in metastatic melanoma
Published in Journal of translational medicine (10-12-2020)“…The diagnosis of check-point inhibitor-related pneumonitis (CIP) relies on radiological and clinical patterns which are not specific and can mimic other…”
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Cemiplimab in an Elderly Frail Population of Patients With Locally Advanced or Metastatic Cutaneous Squamous Cell Carcinoma: A Single-Center Real-Life Experience From Italy
Published in Frontiers in oncology (08-11-2021)“…Cutaneous squamous cell carcinoma (CSCC) is the second most common skin cancer whose incidence is growing parallel to the lengthening of the average lifespan…”
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A Patient With Stage III Locally Advanced Pancreatic Adenocarcinoma Treated With Intra-Arterial Infusion FOLFIRINOX: Impressive Tumoral Response and Death due to Legionella pneumophila Infection: A Unique Case Report
Published in Frontiers in oncology (31-03-2022)“…Patients affected by pancreatic ductal adenocarcinoma (PDAC) have very poor prognosis, whereby at a follow-up of 5 years, the mortality rate is very similar to…”
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Electrochemotherapy as a Trigger to Overcome Primary Resistance to Anti-PD-1 Treatment: A Case Report of Melanoma of the Scalp
Published in Frontiers in oncology (16-09-2021)“…Immunotherapy with immune checkpoint inhibitors is one of the main therapies for advanced melanoma. Nevertheless, albeit remarkable, immunotherapy results are…”
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Somatostatin Receptors in Merkel-Cell Carcinoma: A Therapeutic Opportunity Using Somatostatin Analog Alone or in Association With Checkpoint Inhibitors Immunotherapy. A Case Report
Published in Frontiers in oncology (07-07-2020)“…Background: Merkel-cell carcinoma (MCC) is a rare, highly aggressive skin cancer typically involving elderly people. Surgery is usually the first treatment for…”
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Corrigendum: The molecular tumor board as a step in cancer patient management: a southern Italian experience
Published in Frontiers in medicine (25-10-2024)“…[This corrects the article DOI: 10.3389/fmed.2024.1432628.].[This corrects the article DOI: 10.3389/fmed.2024.1432628.]…”
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The molecular tumor board as a step in cancer patient management: a southern Italian experience
Published in Frontiers in medicine (11-09-2024)“…The management of cancer patients follows a Diagnostic Therapeutic and Care Pathway (PDTA) approach, aimed at achieving the optimal balance between care and…”
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Angiogenesis in adenosquamous cancer of pancreas
Published in Oncotarget (10-11-2017)Get full text
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PD-L1 and Notch as novel biomarkers in pancreatic sarcomatoid carcinoma: a pilot study
Published in Expert opinion on therapeutic targets (02-11-2021)“…The improved immunological understanding revealed the tumor microenvironment as an appealing driver to restore the immune response against cancer cells…”
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BRAFV600E;K601Q metastatic melanoma patient-derived organoids and docking analysis to predict the response to targeted therapy
Published in Pharmacological research (01-08-2022)“…The V600E mutation in BRAF is associated with increased phosphorylation of Erk1/2 and high sensitivity to BRAFi/MEKi combination in metastatic melanoma. In…”
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An artificial intelligence-based model exploiting H&E images to predict recurrence in negative sentinel lymph-node melanoma patients
Published in Journal of translational medicine (12-09-2024)“…Risk stratification and treatment benefit prediction models are urgent to improve negative sentinel lymph node (SLN-) melanoma patient selection, thus avoiding…”
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Frizzled-10 and cancer progression: Is it a new prognostic marker?
Published in Oncotarget (02-01-2018)“…Frizzled (FZD) proteins, a family of Wnt receptors, are involved in carcinogenesis in different organs. One interesting FZD protein is FZD-10 highly expressed…”
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uPAR controls vasculogenic mimicry ability expressed by drug-resistant melanoma cells
Published in Oncology research (31-01-2022)“…Malignant melanoma is a highly aggressive skin cancer characterized by an elevated grade of tumor cell plasticity. Such plasticity allows melanoma cells…”
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Hierarchical clustering analysis identifies metastatic colorectal cancers patients with more aggressive phenotype
Published in Oncotarget (20-10-2017)“…A large percentage of metastatic colorectal cancer (mCRC) patients presents metastasis at the time of diagnosis. In the last years, great efforts have been…”
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The Management of Oligoprogression in the Landscape of New Therapies for Metastatic Melanoma
Published in Cancers (14-10-2019)“…Background: A limited degree of progression after a response to treatment is labelled as oligoprogression and is a hot topic of metastatic melanoma (MM)…”
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The Interaction between Reactive Peritoneal Mesothelial Cells and Tumor Cells via Extracellular Vesicles Facilitates Colorectal Cancer Dissemination
Published in Cancers (20-05-2021)“…Advanced colorectal cancer (CRC) is highly metastatic and often results in peritoneal dissemination. The extracellular vesicles (EVs) released by cancer cells…”
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