Search Results - "Fuat Oduncu"

Perioperative chemotherapy with fluorouracil plus leucovorin, oxaliplatin, and docetaxel versus fluorouracil or capecitabine plus cisplatin and epirubicin for locally advanced, resectable gastric or gastro-oesophageal junction adenocarcinoma (FLOT4): a randomised, phase 2/3 trial by Al-Batran, Salah-Eddin, Homann, Nils, Pauligk, Claudia, Goetze, Thorsten O, Meiler, Johannes, Kasper, Stefan, Kopp, Hans-Georg, Mayer, Frank, Haag, Georg Martin, Luley, Kim, Lindig, Udo, Schmiegel, Wolff, Pohl, Michael, Stoehlmacher, Jan, Folprecht, Gunnar, Probst, Stephan, Prasnikar, Nicole, Fischbach, Wolfgang, Mahlberg, Rolf, Trojan, Jörg, Koenigsmann, Michael, Martens, Uwe M, Thuss-Patience, Peter, Egger, Matthias, Block, Andreas, Heinemann, Volker, Illerhaus, Gerald, Moehler, Markus, Schenk, Michael, Kullmann, Frank, Behringer, Dirk M, Heike, Michael, Pink, Daniel, Teschendorf, Christian, Löhr, Carmen, Bernhard, Helga, Schuch, Gunter, Rethwisch, Volker, von Weikersthal, Ludwig Fischer, Hartmann, Jörg T, Kneba, Michael, Daum, Severin, Schulmann, Karsten, Weniger, Jörg, Belle, Sebastian, Gaiser, Timo, Oduncu, Fuat S, Güntner, Martina, Hozaeel, Wael, Reichart, Alexander, Jäger, Elke, Kraus, Thomas, Mönig, Stefan, Bechstein, Wolf O, Schuler, Martin, Schmalenberg, Harald, Hofheinz, Ralf D

“…Docetaxel-based chemotherapy is effective in metastatic gastric and gastro-oesophageal junction adenocarcinoma. This study reports on the safety and efficacy…”
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Systematic immunohistochemical screening for mismatch repair and ERCC1 gene expression from colorectal cancers in China: Clinicopathological characteristics and effects on survival by Li, Pan, Xiao, Zhitao, Braciak, Todd A, Ou, Qingjian, Chen, Gong, Oduncu, Fuat S

“…We performed a systematic screening of colorectal cancer (CRC) tissues to investigate whether mismatch repair (MMR) status and ERCC1 protein expression could…”
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A relationship to survival is seen by combining the factors of mismatch repair status, tumor location and age of onset in colorectal cancer patients by Li, Pan, Xiao, Zhitao, Braciak, Todd A, Ou, Qingjian, Chen, Gong, Oduncu, Fuat S

“…The progression of colorectal cancer (CRC) may differ depending on the location of the tumor and the age of onset of the disease. Previous studies also…”
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FLOT Versus FLOT/Trastuzumab/Pertuzumab Perioperative Therapy of Human Epidermal Growth Factor Receptor 2-Positive Resectable Esophagogastric Adenocarcinoma: A Randomized Phase II Trial of the AIO EGA Study Group by Hofheinz, Ralf-Dieter, Merx, Kirsten, Haag, Georg M, Springfeld, Christoph, Ettrich, Thomas, Borchert, Kersten, Kretzschmar, Albrecht, Teschendorf, Christian, Siegler, Gabriele, Ebert, Matthias P, Goekkurt, Eray, Mahlberg, Rolf, Homann, Nils, Pink, Daniel, Bechstein, Wolf, Reichardt, Peter, Flach, Hagen, Gaiser, Timo, Battmann, Achim, Oduncu, Fuat S, Loose, Maria, Sookthai, Disorn, Pauligk, Claudia, Göetze, Thorsten O, Al-Batran, Salah-Eddin

“…High pathologic complete response (pCR) rates and comparably good survival data were seen in a phase II trial combining perioperative fluorouracil, leucovorin,…”
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Hematologic Malignancies in Pregnancy: Management Guidelines From an International Consensus Meeting by Lishner, Michael, Avivi, Irit, Apperley, Jane F, Dierickx, Daan, Evens, Andrew M, Fumagalli, Monica, Nulman, Irena, Oduncu, Fuat S, Peccatori, Fedro Alessandro, Robinson, Susan, Van Calsteren, Kristel, Vandenbroucke, Tineke, Van den Heuvel, Frank, Amant, Frederic

“…The incidence of hematologic malignancies during pregnancy is 0.02%. However, this figure is increasing, as women delay conception until a later age. Systemic…”
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MicroRNA-192-5p is a predictive biomarker of survival for Stage IIIB colon cancer patients by Li, Pan, Ou, Qingjian, Braciak, Todd A, Chen, Gong, Oduncu, Fuat S

“…We found that miRNA-192-5p could serves as a potential diagnostic and/or therapeutic target in colon cancer. Abstract Background The poor clinical prognosis of…”
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The ethics of deep brain stimulation (DBS) by Unterrainer, Marcus, Oduncu, Fuat S.

“…Deep brain stimulation (DBS) is an invasive technique designed to stimulate certain deep brain regions for therapeutic purposes and is currently used mainly in…”
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Association between Ki67 Index and Clinicopathological Features in Colorectal Cancer by Li, Pan, Xiao, Zhi-Tao, Braciak, Todd A, Ou, Qing-Jan, Chen, Gong, Oduncu, Fuat S

“…Conflicting results have been reported about the association between the Ki67 labeling index (Ki67-Li) and clinical outcome in patients with colorectal cancer…”
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The novel inhibitor of histone deacetylase resminostat (RAS2410) inhibits proliferation and induces apoptosis in multiple myeloma (MM) cells by Mandl‐Weber, Sonja, Meinel, Felix G., Jankowsky, Rüdiger, Oduncu, Fuat, Schmidmaier, Ralf, Baumann, Philipp

“…Summary Inhibition of histone deacetylase (HDAC) is a promising mechanism for novel, anti‐myeloma agents. We investigated the effects of the novel HDAC…”
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Root Resorption Caused by Jaw Infiltration of Multiple Myeloma: Report of a Case and Literature Review by Troeltzsch, Matthias, MD, DMD, Oduncu, Fuat, MD, PhD, Mayr, Doris, MD, PhD, Ehrenfeld, Michael, MD, DMD, PhD, Pautke, Christoph, MD, DMD, PhD, Otto, Sven, MD, DMD, PhD

“…Abstract Introduction Infiltration of the maxillofacial region by multiple myeloma is common and typically appears as punched out osteolytic lesions of the…”
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Dihydroorotate dehydrogenase inhibitor A771726 (leflunomide) induces apoptosis and diminishes proliferation of multiple myeloma cells by Philipp Baumann, Sonja Mandl-Weber, Andreas Völkl, Christian Adam, Irmgard Bumeder, Fuat Oduncu, Ralf Schmidmaier

“…Multiple myeloma is still an incurable disease; therefore, new therapeutics are urgently needed. A771726 is the active metabolite of the immunosuppressive drug…”
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Priority-setting, rationing and cost-effectiveness in the German health care system by Oduncu, Fuat S.

“…Germany has just started a public debate on priority-setting, rationing and cost-effectiveness due to the cost explosion within the German health care system…”
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The cost-effectiveness of UGT1A1 genotyping before colorectal cancer treatment with irinotecan from the perspective of the German statutory health insurance by Butzke, Bettina, Oduncu, Fuat S, Severin, Franziska, Pfeufer, Arne, Heinemann, Volker, Giessen-Jung, Clemens, Stollenwerk, Björn, Rogowski, Wolf H

“…The evidence concerning the cost-effectiveness of UGT1A1*28 genotyping is ambiguous and does not allow drawing valid conclusions for Germany. This study…”
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Dual-targeting triplebody 33-16-123 (SPM-2) mediates effective redirected lysis of primary blasts from patients with a broad range of AML subtypes in combination with natural killer cells by Braciak, Todd A., Roskopf, Claudia C., Wildenhain, Sarah, Fenn, Nadja C., Schiller, Christian B., Schubert, Ingo A., Jacob, Uwe, Honegger, Annemarie, Krupka, Christina, Subklewe, Marion, Spiekermann, Karsten, Hopfner, Karl-Peter, Fey, Georg H., Aigner, Michael, Krause, Stefan, Mackensen, Andreas, Oduncu, Fuat S.

“…A number of agents designed for immunotherapy of Acute Myeloid Leukemia (AML) are in preclinical and early clinical development. Most of them target a single…”
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Phage idiotype vaccination: first phase I/II clinical trial in patients with multiple myeloma by Roehnisch, Tim, Then, Cornelia, Nagel, Wolfgang, Blumenthal, Christina, Braciak, Todd, Donzeau, Mariel, Böhm, Thomas, Flaig, Michael, Bourquin, Carole, Oduncu, Fuat S

“…Multiple myeloma is characterized by clonal expansion of B cells producing monoclonal immunoglobulins or fragments thereof, which can be detected in the serum…”
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Dual-targeting triplebody 33-3-19 mediates selective lysis of biphenotypic CD19+ CD33+ leukemia cells by Roskopf, Claudia C, Braciak, Todd A, Fenn, Nadja C, Kobold, Sebastian, Fey, Georg H, Hopfner, Karl-Peter, Oduncu, Fuat S

“…Simultaneous targeting of multiple tumor-associated antigens (TAAs) in cancer immunotherapy is presumed to enhance tumor cell selectivity and to reduce immune…”
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A dual-targeting triplebody mediates preferential redirected lysis of antigen double-positive over single-positive leukemic cells by Schubert, Ingo, Saul, Domenica, Nowecki, Stefanie, Mackensen, Andreas, Fey, Georg H, Oduncu, Fuat S

“…The single-chain triplebody HLA-ds16-hu19 consists of three single-chain Fv (scFv) antibody fragments connected in a single polypeptide chain. This protein…”
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Chip-based platform for dynamic analysis of NK cell cytolysis mediated by a triplebody by Chatzopoulou, Elisavet I, Roskopf, Claudia C, Sekhavati, Farzad, Braciak, Todd A, Fenn, Nadja C, Hopfner, Karl-Peter, Oduncu, Fuat S, Fey, Georg H, Rädler, Joachim O

“…Cancer therapy via redirected lysis mediated by antibodies and antibody-derived agents relies on the availability of substantial numbers of sufficiently active…”
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Effective Elimination of Acute Myeloid Leukemic Cells by Recombinant Bispecific Antibody Derivatives Directed Against CD33 and CD16 by SINGER, Heiko, KELLNER, Christian, FEY, Georg H, LANIG, Harald, AIGNER, Michael, STOCKMEYER, Bernhard, ODUNCU, Fuat, SCHWEMMLEIN, Michael, STEIN, Christoph, MENTZ, Kristin, MACKENSEN, Andreas

“…Single-chain Fv triplebodies (sctb), consisting of a single polypeptide chain with 3 single-chain antibody variable fragments connected in tandem, were…”
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ITOC2 – 024. Selective lysis of biphenotypic leukaemia cells is mediated by dual-targeting triplebody 33-3-19 treatment by Claudia, Roskopf C, Todd, Braciak A, Nadja, Fenn, Sebastian, Kobold, Uwe, Jacob, Georg, Fey H, Karl-Peter, Hopfner, Fuat, Oduncu S

“…We recently reported that triplebody 19-3-19 can engage and activate T cells as cytolytic effectors via a central OKT3-derived single chain variable fragment…”
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