Search Results - "Fu, Ying Hui"

Genetics of the human circadian clock and sleep homeostat by Ashbrook, Liza H, Krystal, Andrew D, Fu, Ying-Hui, Ptáček, Louis J

“…Timing and duration of sleep are controlled by the circadian system, which keeps an ~24-h internal rhythm that entrains to environmental stimuli, and the sleep…”
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The intricate dance of post-translational modifications in the rhythm of life by Hirano, Arisa, Fu, Ying-Hui, Ptáček, Louis J

“…Clock proteins are controlled by multiple post-translational modifications during the circadian cycle. In this Review, the authors examine how…”
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The molecular genetics of human sleep by Zhang, Luoying, Fu, Ying‐Hui

“…It has been known for many years that genetic influences account for some of the individual differences in human sleep parameters, but the underlying molecular…”
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Continental Mid‐Lithosphere Discontinuity: A Water Collector During Craton Evolution by Fu, Hui‐Ying, Li, Zhong‐Hai, Chen, Ling

“…Continental mid‐lithosphere discontinuity (MLD) seems to be ubiquitous beneath cratons around the world with the dominant depth of 70–100 km, and is…”
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Adaptive Long‐Read Sequencing Reveals GGC Repeat Expansion in ZFHX3 Associated with Spinocerebellar Ataxia Type 4 by Chen, Zhongbo, Gustavsson, Emil K., Macpherson, Hannah, Anderson, Claire, Clarkson, Chris, Rocca, Clarissa, Self, Eleanor, Alvarez Jerez, Pilar, Scardamaglia, Annarita, Pellerin, David, Montgomery, Kylie, Lee, Jasmaine, Gagliardi, Delia, Luo, Huihui, Hardy, John, Polke, James, Singleton, Andrew B., Blauwendraat, Cornelis, Mathews, Katherine D., Tucci, Arianna, Fu, Ying‐Hui, Houlden, Henry, Ryten, Mina, Ptáček, Louis J.

“…Background Spinocerebellar ataxia type 4 (SCA4) is an autosomal dominant ataxia with invariable sensory neuropathy originally described in a family with…”
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Diverse roles of pontine NPS-expressing neurons in sleep regulation by Xing, Lijuan, Zou, Xianlin, Yin, Chen, Webb, John M, Shi, Guangsen, Ptáček, Louis J, Fu, Ying-Hui

“…Neuropeptide S (NPS) was postulated to be a wake-promoting neuropeptide with unknown mechanism, and a mutation in its receptor (NPSR1) causes the short sleep…”
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Transcriptional Repressor DEC2 Regulates Sleep Length in Mammals by He, Ying, Jones, Christopher R, Fujiki, Nobuhiro, Xu, Ying, Guo, Bin, Holder, Jimmy L. Jr, Rossner, Moritz J, Nishino, Seiji, Fu, Ying-Hui

“…Sleep deprivation can impair human health and performance. Habitual total sleep time and homeostatic sleep response to sleep deprivation are quantitative…”
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Extreme morning chronotypes are often familial and not exceedingly rare: the estimated prevalence of advanced sleep phase, familial advanced sleep phase, and advanced sleep-wake phase disorder in a sleep clinic population by Curtis, Brian John, Ashbrook, Liza H, Young, Terry, Finn, Laurel A, Fu, Ying-Hui, Ptáček, Louis J, Jones, Christopher R

“…Report the first prevalence estimates of advanced sleep phase (ASP), familial advanced sleep phase (FASP), and advanced sleep-wake phase disorder (ASWPD). This…”
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A PERIOD3 variant causes a circadian phenotype and is associated with a seasonal mood trait by Zhang, Luoying, Hirano, Arisa, Hsu, Pei-Ken, Jones, Christopher R., Sakai, Noriaki, Okuro, Masashi, McMahon, Thomas, Yamazaki, Maya, Xu, Ying, Saigoh, Noriko, Saigoh, Kazumasa, Lin, Shu-Ting, Kaasik, Krista, Nishino, Seiji, Ptáček, Louis J., Fu, Ying-Hui

“…In humans, the connection between sleep and mood has long been recognized, although direct molecular evidence is lacking. We identified two rare variants in…”
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A Cryptochrome 2 mutation yields advanced sleep phase in humans by Hirano, Arisa, Shi, Guangsen, Jones, Christopher R, Lipzen, Anna, Pennacchio, Len A, Xu, Ying, Hallows, William C, McMahon, Thomas, Yamazaki, Maya, Ptáček, Louis J, Fu, Ying-Hui

“…Familial Advanced Sleep Phase (FASP) is a heritable human sleep phenotype characterized by very early sleep and wake times. We identified a missense mutation…”
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Dicer ablation in oligodendrocytes provokes neuronal impairment in mice by Shin, Daesung, Shin, Ji-Yeon, McManus, Michael T., Ptáček, Louis J., Fu, Ying-Hui

“…Objective MicroRNAs (miRNAs) regulate gene expression and have many roles in the brain, but a role in oligodendrocyte (OL) function has not been demonstrated…”
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DEC2 modulates orexin expression and regulates sleep by Hirano, Arisa, Hsu, Pei-Ken, Zhang, Luoying, Xing, Lijuan, McMahon, Thomas, Yamazaki, Maya, Ptáček, Louis J., Fu, Ying-Hui

“…Adequate sleep is essential for physical and mental health. We previously identified a missense mutation in the human DEC2 gene (BHLHE41) leading to the…”
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FAD Regulates CRYPTOCHROME Protein Stability and Circadian Clock in Mice by Hirano, Arisa, Braas, Daniel, Fu, Ying-Hui, Ptáček, Louis J.

“…The circadian clock generates biological rhythms of metabolic and physiological processes, including the sleep-wake cycle. We previously identified a missense…”
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A Rare Mutation of β1-Adrenergic Receptor Affects Sleep/Wake Behaviors by Shi, Guangsen, Xing, Lijuan, Wu, David, Bhattacharyya, Bula J., Jones, Christopher R., McMahon, Thomas, Chong, S.Y. Christin, Chen, Jason A., Coppola, Giovanni, Geschwind, Daniel, Krystal, Andrew, Ptáček, Louis J., Fu, Ying-Hui

“…Sleep is crucial for our survival, and many diseases are linked to long-term poor sleep quality. Before we can use sleep to enhance our health and performance…”
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Roles of Continental Mid‐Lithosphere Discontinuity in the Craton Instability Under Variable Tectonic Regimes by Fu, Hui‐Ying, Li, Zhong‐Hai

“…The continental mid‐lithosphere discontinuity (MLD) is widely detected within cratons, with the dominant depth range of 70–100 km and a significant reduction…”
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miR-23 regulation of lamin B1 is crucial for oligodendrocyte development and myelination by Lin, Shu-Ting, Fu, Ying-Hui

“…Duplication of the gene encoding lamin B1 (LMNB1) with increased mRNA and protein levels has been shown to cause severe myelin loss in the brains of…”
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MicroRNA-23a promotes myelination in the central nervous system by Lin, Shu-Ting, Huang, Yong, Zhang, Luoying, Heng, Mary Y., Ptáček, Louis J., Fu, Ying-Hui

“…Demyelinating disorders including leukodystrophies are devastating conditions that are still in need of better understanding, and both oligodendrocyte…”
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A Mitochondrial tRNA Mutation Causes Axonal CMT in a Large Venezuelan Family by Fay, Alexander, Garcia, Yngo, Margeta, Marta, Maharjan, Sunita, Jürgensen, Claudia, Briceño, Jose, Garcia, Mariaelena, Yin, Sitao, Bassaganyas, Laia, McMahon, Thomas, Hou, Ya‐Ming, Fu, Ying‐Hui, Ptáček, Louis J.

“…Objective The objective of this study was to identify the genetic cause for progressive peripheral nerve disease in a Venezuelan family. Despite the growing…”
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Lamin B1 duplications cause autosomal dominant leukodystrophy by Fu, Ying-Hui, Padiath, Quasar S, Saigoh, Kazumasa, Schiffmann, Raphael, Asahara, Hideaki, Yamada, Takeshi, Koeppen, Anulf, Hogan, Kirk, Ptá ek, Louis J

“…Adult-onset autosomal dominant leukodystrophy (ADLD) is a slowly progressive neurological disorder characterized by symmetrical widespread myelin loss in the…”
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Very large G protein-coupled receptor 1 regulates myelin-associated glycoprotein via Gαs/Gαq-mediated protein kinases A/C by Shin, Daesung, Lin, Shu-Ting, Fu, Ying-Hui, Ptáček, Louis J.

“…VLGR1 (very large G protein-coupled receptor 1), also known as MASS1 (monogenic audiogenic seizure susceptible 1), is an orphan G protein-coupled receptor that…”
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