Search Results - "Fu, Wenqing"

Analysis of 6,515 exomes reveals the recent origin of most human protein-coding variants by Fu, Wenqing, O’Connor, Timothy D., Jun, Goo, Kang, Hyun Min, Abecasis, Goncalo, Leal, Suzanne M., Gabriel, Stacey, Rieder, Mark J., Altshuler, David, Shendure, Jay, Nickerson, Deborah A., Bamshad, Michael J., NHLBI Exome Sequencing Project, Akey, Joshua M.

“…Resequencing of genes from individuals of European and African American ancestry indicates that approximately 73% of all protein-coding SNVs and approximately…”
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Exonic Transcription Factor Binding Directs Codon Choice and Affects Protein Evolution by Stergachis, Andrew B., Haugen, Eric, Shafer, Anthony, Fu, Wenqing, LeProust, M., Akey, Joshua M., Stamatoyannopoulos, John A.

“…Genomes contain both a genetic code specifying amino acids and a regulatory code specifying transcription factor (TF) recognition sequences. We used genomic…”
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Evolution and Functional Impact of Rare Coding Variation from Deep Sequencing of Human Exomes by Tennessen, Jacob A., Bigham, Abigail W., O'Connor, Timothy D., Fu, Wenqing, Kenny, Eimear E., Gravel, Simon, McGee, Sean, Do, Ron, Liu, Xiaoming, Jun, Goo, Kang, Hyun Min, Jordan, Daniel, Leal, Suzanne M., Gabriel, Stacey, Rieder, Mark J., Abecasis, Goncalo, Altshuler, David, Nickerson, Deborah A., Boerwinkle, Eric, Sunyaev, Shamil, Bustamante, Carlos D., Bamshad, Michael J., Akey, Joshua M.

“…As a first step toward understanding how rare variants contribute to risk for complex diseases, we sequenced 15,585 human protein-coding genes to an average…”
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Evolutionary history and adaptation of a human pygmy population of Flores Island, Indonesia by Tucci, Serena, Vohr, Samuel H, McCoy, Rajiv C, Vernot, Benjamin, Robinson, Matthew R, Barbieri, Chiara, Nelson, Brad J, Fu, Wenqing, Purnomo, Gludhug A, Sudoyo, Herawati, Eichler, Evan E, Barbujani, Guido, Visscher, Peter M, Akey, Joshua M, Green, Richard E

“…Flores Island, Indonesia, was inhabited by the small-bodied hominin species , which has an unknown evolutionary relationship to modern humans. This island is…”
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Multiplex Targeted Sequencing Identifies Recurrently Mutated Genes in Autism Spectrum Disorders by O'Roak, Brian J., Vives, Laura, Fu, Wenqing, Egertson, Jarrett D., Stanaway, Ian B., Phelps, Ian G., Carvill, Gemma, Kumar, Akash, Lee, Choli, Ankenman, Katy, Munson, Jeff, Hiatt, Joseph B., Turner, Emily H., Levy, Roie, O'Day, Diana R., Krumm, Niklas, Coe, Bradley P., Martin, Beth K., Borenstein, Elhanan, Nickerson, Deborah A., Mefford, Heather C., Doherty, Dan, Akey, Joshua M., Bernier, Raphael, Eichler, Evan E., Shendure, Jay

“…Exome sequencing studies of autism spectrum disorders (ASDs) have identified many de novo mutations but few recurrently disrupted genes. We therefore developed…”
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Evolutionary History and Adaptation from High-Coverage Whole-Genome Sequences of Diverse African Hunter-Gatherers by Lachance, Joseph, Vernot, Benjamin, Elbers, Clara C., Ferwerda, Bart, Froment, Alain, Bodo, Jean-Marie, Lema, Godfrey, Fu, Wenqing, Nyambo, Thomas B., Rebbeck, Timothy R., Zhang, Kun, Akey, Joshua M., Tishkoff, Sarah A.

“…To reconstruct modern human evolutionary history and identify loci that have shaped hunter-gatherer adaptation, we sequenced the whole genomes of five…”
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Spatial-resolved metabolomics reveals tissue-specific metabolic reprogramming in diabetic nephropathy by using mass spectrometry imaging by Wang, Zhonghua, Fu, Wenqing, Huo, Meiling, He, Bingshu, Liu, Yaqi, Tian, Lu, Li, Wanfang, Zhou, Zhi, Wang, Baili, Xia, Jianzhen, Chen, Yanhua, Wei, Jinfeng, Abliz, Zeper

“…Detailed knowledge on tissue-specific metabolic reprogramming in diabetic nephropathy (DN) is vital for more accurate understanding the molecular pathological…”
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In situ metabolomics in nephrotoxicity of aristolochic acids based on air flow-assisted desorption electrospray ionization mass spectrometry imaging by Wang, Zhonghua, He, Bingshu, Liu, Yaqi, Huo, Meiling, Fu, Wenqing, Yang, Chunyan, Wei, Jinfeng, Abliz, Zeper

“…Understanding of the nephrotoxicity induced by drug candidates is vital to drug discovery and development. Herein, an in situ metabolomics method based on air…”
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Genomic Dissection of Population Substructure of Han Chinese and Its Implication in Association Studies by Xu, Shuhua, Yin, Xianyong, Li, Shilin, Jin, Wenfei, Lou, Haiyi, Yang, Ling, Gong, Xiaohong, Wang, Hongyan, Shen, Yiping, Pan, Xuedong, He, Yungang, Yang, Yajun, Wang, Yi, Fu, Wenqing, An, Yu, Wang, Jiucun, Tan, Jingze, Qian, Ji, Chen, Xiaoli, Zhang, Xin, Sun, Yangfei, Zhang, Xuejun, Wu, Bailin, Jin, Li

“…To date, most genome-wide association studies (GWAS) and studies of fine-scale population structure have been conducted primarily on Europeans. Han Chinese,…”
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Optimization of Electric Vehicle Routes Considering Multi-Temperature Co-Distribution in Cold Chain Logistics with Soft Time Windows by He, Meiling, Yang, Mei, Fu, Wenqing, Wu, Xiaohui, Izui, Kazuhiro

“…Inspired by the practice of urban distribution of fresh products, we introduce a new electric vehicle routing problem with soft time windows. In this problem,…”
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In situ label-free visualization of tissue distributions of salidroside in multiple mouse organs by MALDI-MS imaging by Meng, Xianyue, Fu, Wenqing, Huo, Meiling, Liu, Yaqi, Zhang, Zixuan, Wei, Jinfeng, Wang, Zhonghua, Abliz, Zeper

“…Detailed knowledge on the spatiotemporal distribution of drugs or drug candidates in bio-tissues is of vital importance for the determination of their…”
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An Identification Method of the Externality of Cultural Facilities from the Perspective of Spatial Distribution of Cultural Industry: A Case Study of Ningbo, China by Zhu, Baoyu, Ma, Renfeng, Luo, Maoyu, Wu, Lingzhi, Fu, Wenqing

“…The identification and depiction of the externality of urban facilities have always been a hot and challenging research issue in human geography and urban…”
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Adaptive Fuzzy Synchronization of Fractional-Order Chaotic Neural Networks with Backlash-Like Hysteresis by Fu, Wenqing, Liu, Heng

“…An adaptive fuzzy synchronization controller is designed for a class of fractional-order neural networks (FONNs) subject to backlash-like hysteresis input…”
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Perception Analysis of the Transformation from a Fishery-Led to Industry-Led Island with its Human Settlement Changes: A Case Study of Liuheng Island, Zhoushan City, China by Fu, Wenqing, Ma, Renfeng, Liang, Xianjun, Zhao, Yiran, Wu, Lingzhi, Luo, Maoyu, Mao, Yanjun

“…Based on the theories of industrial structure and settlement environment, this paper conducts a quantitative and qualitative study to investigate how the…”
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Adaptive evolution of the FADS gene cluster within Africa by Mathias, Rasika A, Fu, Wenqing, Akey, Joshua M, Ainsworth, Hannah C, Torgerson, Dara G, Ruczinski, Ingo, Sergeant, Susan, Barnes, Kathleen C, Chilton, Floyd H

“…Long chain polyunsaturated fatty acids (LC-PUFAs) are essential for brain structure, development, and function, and adequate dietary quantities of LC-PUFAs are…”
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Identification and antiviral activity of common polymorphisms in the APOBEC3 locus in human populations by Duggal, Nisha K, Fu, Wenqing, Akey, Joshua M, Emerman, Michael

“…Abstract There are seven members of the APOBEC3 family in humans (APOBEC3A through APOBEC3H) that have antiviral activity against retroviruses and/or…”
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Identification of Key Genes of Fruit Shape Variation in Jujube with Integrating Elliptic Fourier Descriptors and Transcriptome by Ren, Yue, Fu, Wenqing, Gao, Yi, Chen, Yuhan, Kong, Decang, Cao, Ming, Pang, Xiaoming, Bo, Wenhao

“…Jujube ( ) exhibits a rich diversity in fruit shape, with natural occurrences of gourd-like, flattened, and other special shapes. Despite the ongoing research…”
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Exploring Accessibility and Its Impact in the Mountain City: A Typical Case Study of Nyingchi City, Tibet Autonomous Region, China by Gong, Qianqian, Li, Jiaming, Wu, Lingzhi, Zhu, Miner, Luo, Maoyu, Sun, Jingyi, Fu, Wenqing, Ma, Renfeng, Liang, Xianjun

“…The accessibility of mountain tourist attractions is a prerequisite to enhancing the attractiveness of tourist attractions and driving the well-being of local…”
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Present Y chromosomes reveal the ancestry of Emperor CAO Cao of 1800 years ago by Wang, Chuanchao, Yan, Shi, Hou, Zheng, Fu, Wenqing, Xiong, Momiao, Han, Sheng, Jin, Li, Li, Hui

“…Emperor CAO Cao (155AD-220AD) is one of the most famous persons in Chinese history that had changed the history of East Asia. He claimed to be a descendant of…”
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Identification of Copy Number Variation Hotspots in Human Populations by Fu, Wenqing, Zhang, Feng, Wang, Yi, Gu, Xun, Jin, Li

“…Copy number variants (CNVs) in the human genome contribute to both Mendelian and complex traits as well as to genomic plasticity in evolution. The…”
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