Search Results - "Fu, Liangfeng"

New Synthetic Triterpenoids: Potent Agents for Prevention and Treatment of Tissue Injury Caused by Inflammatory and Oxidative Stress by Sporn, Michael B, Liby, Karen T, Yore, Mark M, Fu, Liangfeng, Lopchuk, Justin M, Gribble, Gordon W

“…We review the original rationale for the development and the chemistry of a series of new synthetic oleanane triterpenoids (SO), based on oleanolic acid (1) as…”
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General Methodology for the Preparation of 2,5-Disubstituted-1,3-oxazoles by Williams, David R, Fu, Liangfeng

“…Deprotonation of 2-(phenylsulfonyl)-1,3-oxazole (1) readily provides a useful C-5 carbanion that is reactive with a variety of electrophiles. Aldehydes and…”
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Total synthesis of lycogarubin C utilizing the Kornfeld–Boger ring contraction by Fu, Liangfeng, Gribble, Gordon W.

“…An efficient synthesis of lycogarubin C ( 3) was completed in seven steps from the known 1-(phenylsulfonyl)indole-3-carbaldehyde in 30% overall yield, via a…”
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Synthesis of a monofluoro 3-alkyl-2-hydroxy-1,4-naphthoquinone: a potential anti-malarial drug by Kim, Eliana E., Onyango, Evans O., Fu, Liangfeng, Gribble, Gordon W.

“…[Display omitted] Monofluorinated 3-alkyl-2-hydroxy-1,4-naphthoquinone 4 was prepared in eight steps from commercially available 8-bromooctanoic acid (10). The…”
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Synthesis of a Dicyano Abietane, a Key Intermediate for the Anti-inflammatory Agent TBE-31 by Onyango, Evans O, Fu, Liangfeng, Gribble, Gordon W

“…The synthesis of dicyano abietane 11, a potential precursor to the biologically active tricyclic bis-cyano enone 6 (TBE-31), was accomplished in eight steps…”
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A simple synthesis of 2,2′-bipyrroles from pyrrole by Fu, Liangfeng, Gribble, Gordon W.

“…A simple three-step synthesis of 2,2′-bipyrroles from pyrrole is described. 2,2′-Bipyrroles, which are obvious precursors for the synthesis of…”
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Synthesis and biological evaluation of amino acid methyl ester conjugates of 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid against the production of nitric oxide (NO) by Onyango, Evans O., Fu, Liangfeng, Cao, Martine, Liby, Karen T., Sporn, Michael B., Gribble, Gordon W.

“…2-Cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid (CDDO, 2) was condensed with various amino acid methyl esters at the C-28 carboxylic acid. The new amide…”
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Synthesis of Pyrrolo[1,2-c]pyrimidines by W. Gribble, Gordon, Narayan, Easha

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A convenient Fischer indole synthesis of 2,3′-biindoles by Alford, Philip E., Fu, Liangfeng, Kubert, Joseph K., Wang, Lingshan, Gribble, Gordon W.

“…2,3′-Biindoles are readily synthesized from 3-acyl-1-(phenylsulfonyl)indoles in good to excellent yields. Substituent effects provide insight into the scope of…”
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Efficient and Scalable Synthesis of Bardoxolone Methyl (CDDO-methyl Ester) by Fu, Liangfeng, Gribble, Gordon W

“…Bardoxolone methyl (2-cyano-3,12-dioxooleane-1,9(11)-dien-28-oic acid methyl ester; CDDO-Me) (1), a synthetic oleanane triterpenoid with highly potent…”
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7-Chloro-3-(4-methyl-benzene-sulfon-yl)pyrrolo[1,2- c ]pyrimidine by Narayan, Easha, Fu, Liangfeng, Gribble, Gordon W, Kaur, Manpreet, Jasinski, Jerry P

“…In the title compound, C H ClN O S, the dihedral angle between the pyrrolo-[1,2- ]pyrimidine ring system (r.m.s. deviation = 0.008 Å) and the benzene ring is…”
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Synthesis of 1,2′- and 1,3′-bipyrroles from 2- and 3-nitropyrroles by Fu, Liangfeng, Gribble, Gordon W.

“…1,2′- and 1,3′-Bipyrroles, which are attractive precursors for the synthesis of bipyrrole-based natural products, are synthesized in one-pot from 2- and…”
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Synthesis of a furano abietane cyano enone—A new scaffold for biological exploration by Onyango, Evans O., Fu, Liangfeng, Gribble, Gordon W.

“…A six step synthesis of furano abietane cyano enone 12 is described, in which the key step is a palladium-catalyzed intramolecular Heck reaction of bromo…”
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Design, synthesis, and biological activity of second-generation synthetic oleanane triterpenoids by Fu, Liangfeng, Lin, Qi-Xian, Onyango, Evans O, Liby, Karen T, Sporn, Michael B, Gribble, Gordon W

“…We report the synthesis and biological activity of C-24 demethyl CDDO-Me 2 and the C-28 amide derivatives 3 and 4, which are analogues of the anti-inflammatory…”
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Reductive acylation of 2- and 3-nitropyrroles—efficient syntheses of pyrrolylamides and pyrrolylimides by Fu, Liangfeng, Gribble, Gordon W.

“…Both 2- and 3-nitropyrroles are reductively acylated under catalytic hydrogenation conditions in the presence of alicyclic and cyclic carboxylic acid…”
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An efficient synthesis of methyl 2-cyano-3,12-dioxoursol-1,9-dien-28-oate (CDDU-methyl ester): analogues, biological activities, and comparison with oleanolic acid derivatives by Fu, Liangfeng, Lin, Qi-Xian, Liby, Karen T, Sporn, Michael B, Gribble, Gordon W

“…An efficient synthesis of methyl 2-cyano-3,12-dioxoursol-1,9-dien-28-oate (CDDU-methyl ester) from commercially available ursolic acid, which features an…”
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Three-component reductive alkylation of 2-hydroxy-1,4-naphthoquinones with lactols by Kim, Eliana E., Onyango, Evans O., Pace, Jennifer R., Abbot, Timothy M., Fu, Liangfeng, Gribble, Gordon W.

“…[Display omitted] Lactols II, obtained by DIBAL reduction of their corresponding lactones I, in equilibrium with their hydroxyaldehyde tautomers III were used…”
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A SHORT SYNTHESIS OF THE NATURALLY OCCURRING 2,3,3′,4,4′,5,5′-HEPTACHLORO- ("Q1") AND HEPTABROMO-1′-METHYL-1,2′-BIPYRROLES by Fu, Liangfeng, Gribble, Gordon W.

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Enantioseparation and absolute configuration of the atropisomers of a naturally produced hexahalogenated 1,1′-dimethyl-2,2′-bipyrrole by Rosenfelder, Natalie, Ostrowicz, Patrizia, Fu, Liangfeng, Gribble, Gordon W., Tittlemier, Sheryl A., Frey, Wolfgang, Vetter, Walter

“…Hexahalogenated 1,1′-dimethyl-2,2′-bipyrroles (HDBPs) are a group of marine halogenated natural products (HNPs) that have been detected in environmental…”
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Synthetic studies towards the syntheses of 2,3,3′ ,4,4′,5,5′-heptachloro-1′-methyl-1,2′-bipyrrole (Q1), Lycogarubin C and cis-Trikentrin A by Fu, Liangfeng

“…The novel heptachloro-1'-methyl-1,2'-bipyrrole ("Q1") (1) is a natural organohalogen that has been detected in more than 100 worldwide environmental samples…”
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