Search Results - "Fu, Jingxin"

TIMER2.0 for analysis of tumor-infiltrating immune cells by Li, Taiwen, Fu, Jingxin, Zeng, Zexian, Cohen, David, Li, Jing, Chen, Qianming, Li, Bo, Liu, X Shirley

“…Abstract Tumor progression and the efficacy of immunotherapy are strongly influenced by the composition and abundance of immune cells in the tumor…”
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Large-scale public data reuse to model immunotherapy response and resistance by Fu, Jingxin, Li, Karen, Zhang, Wubing, Wan, Changxin, Zhang, Jing, Jiang, Peng, Liu, X Shirley

“…Despite growing numbers of immune checkpoint blockade (ICB) trials with available omics data, it remains challenging to evaluate the robustness of ICB response…”
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In vivo CRISPR screens identify the E3 ligase Cop1 as a modulator of macrophage infiltration and cancer immunotherapy target by Wang, Xiaoqing, Tokheim, Collin, Gu, Shengqing Stan, Wang, Binbin, Tang, Qin, Li, Yihao, Traugh, Nicole, Zeng, Zexian, Zhang, Yi, Li, Ziyi, Zhang, Boning, Fu, Jingxin, Xiao, Tengfei, Li, Wei, Meyer, Clifford A., Chu, Jun, Jiang, Peng, Cejas, Paloma, Lim, Klothilda, Long, Henry, Brown, Myles, Liu, X. Shirley

“…Despite remarkable clinical efficacy of immune checkpoint blockade (ICB) in cancer treatment, ICB benefits for triple-negative breast cancer (TNBC) remain…”
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Landscape of B cell immunity and related immune evasion in human cancers by Hu, Xihao, Zhang, Jian, Wang, Jin, Fu, Jingxin, Li, Taiwen, Zheng, Xiaoqi, Wang, Binbin, Gu, Shengqing, Jiang, Peng, Fan, Jingyu, Ying, Xiaomin, Zhang, Jing, Carroll, Michael C., Wucherpfennig, Kai W., Hacohen, Nir, Zhang, Fan, Zhang, Peng, Liu, Jun S., Li, Bo, Liu, X. Shirley

“…Tumor-infiltrating B cells are an important component in the microenvironment but have unclear anti-tumor effects. We enhanced our previous computational…”
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Therapeutically Increasing MHC-I Expression Potentiates Immune Checkpoint Blockade by Gu, Shengqing Stan, Zhang, Wubing, Wang, Xiaoqing, Jiang, Peng, Traugh, Nicole, Li, Ziyi, Meyer, Clifford, Stewig, Blair, Xie, Yingtian, Bu, Xia, Manos, Michael P, Font-Tello, Alba, Gjini, Evisa, Lako, Ana, Lim, Klothilda, Conway, Jake, Tewari, Alok K, Zeng, Zexian, Sahu, Avinash Das, Tokheim, Collin, Weirather, Jason L, Fu, Jingxin, Zhang, Yi, Kroger, Benjamin, Liang, Jin Hua, Cejas, Paloma, Freeman, Gordon J, Rodig, Scott, Long, Henry W, Gewurz, Benjamin E, Hodi, F Stephen, Brown, Myles, Liu, X Shirley

“…Immune checkpoint blockade (ICB) therapy revolutionized cancer treatment, but many patients with impaired MHC-I expression remain refractory. Here, we combined…”
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Enhancement of oral bioavailability of quercetin by metabolic inhibitory nanosuspensions compared to conventional nanosuspensions by Li, Haowen, Li, Manzhen, Fu, Jingxin, Ao, Hui, Wang, Weihua, Wang, Xiangtao

“…Quercetin-loaded nanosuspensions (Que-NSps) added metabolic inhibitors were evaluated as drug delivery system to promote the oral bioavailability of quercetin…”
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Glycoprotein In Vitro N-Glycan Processing Using Enzymes Expressed in E. coli by Zhang, Libo, Li, Yanhong, Li, Riyao, Yang, Xiaohong, Zheng, Zimin, Fu, Jingxin, Yu, Hai, Chen, Xi

“…Protein N-glycosylation is a common post-translational modification that plays significant roles on the structure, property, and function of glycoproteins. Due…”
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Ginsenoside Rb1 stabilized and paclitaxel / protopanaxadiol co-loaded nanoparticles for synergistic treatment of breast tumor by Lu, Likang, Ao, Hui, Fu, Jingxin, Li, Manzhen, Guo, Yaoyao, Guo, Yifei, Han, Meihua, Shi, Rongxing, Wang, Xiangtao

“…Ginsenosides are the major and key components for ginseng to exert its wide and beneficial therapeutic efficacy in clinic. Meanwhile, many ginsenosides and…”
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A simple but efficient tumor-targeted nanoparticle delivery system constructed by oleic acid by Fu, Jingxin, Wang, Yian, Li, Haowen, Lu, Likang, Han, Meihua, Guo, Yifei, Wang, Xiangtao

“…Oleic acid (OA) is a kind of monounsaturated omega-3 fatty acid that abounds in plants and animals which can induce apoptosis and has broad-spectrum inhibitory…”
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A γ-Glutamyl Transpeptidase (GGT)-Triggered Charge Reversal Drug-Delivery System for Cervical Cancer Treatment: In Vitro and In Vivo Investigation by Fu, Jingxin, Lu, Likang, Li, Manzhen, Guo, Yaoyao, Han, Meihua, Guo, Yifei, Wang, Xiangtao

“…Neutral/negatively charged nanoparticles are beneficial to reduce plasma protein adsorption and prolong their blood circulation time, while positively charged…”
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Molecular and cellular features of CTLA-4 blockade for relapsed myeloid malignancies after transplantation by Penter, Livius, Zhang, Yi, Savell, Alexandra, Huang, Teddy, Cieri, Nicoletta, Thrash, Emily M., Kim-Schulze, Seunghee, Jhaveri, Aashna, Fu, Jingxin, Ranasinghe, Srinika, Li, Shuqiang, Zhang, Wandi, Hathaway, Emma S., Nazzaro, Matthew, Kim, Haesook T., Chen, Helen, Thurin, Magdalena, Rodig, Scott J., Severgnini, Mariano, Cibulskis, Carrie, Gabriel, Stacey, Livak, Kenneth J., Cutler, Corey, Antin, Joseph H., Nikiforow, Sarah, Koreth, John, Ho, Vincent T., Armand, Philippe, Ritz, Jerome, Streicher, Howard, Neuberg, Donna, Hodi, F. Stephen, Gnjatic, Sacha, Soiffer, Robert J., Liu, X. Shirley, Davids, Matthew S., Bachireddy, Pavan, Wu, Catherine J.

“…Relapsed myeloid disease after allogeneic stem cell transplantation (HSCT) remains largely incurable. We previously demonstrated the potent activity of immune…”
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Enhanced tumor accumulation and therapeutic efficacy of liposomal drugs through over-threshold dosing by Ao, Hui, Wang, Zhuo, Lu, Likang, Ma, Hongwei, Li, Haowen, Fu, Jingxin, Li, Manzhen, Han, Meihua, Guo, Yifei, Wang, Xiangtao

“…Most intravenously administered drug-loaded nanoparticles are taken up by liver Kupffer cells, and only a small portion can accumulate at the tumor, resulting…”
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Clonal tracing reveals diverse patterns of response to immune checkpoint blockade by Gu, Shengqing Stan, Wang, Xiaoqing, Hu, Xihao, Jiang, Peng, Li, Ziyi, Traugh, Nicole, Bu, Xia, Tang, Qin, Wang, Chenfei, Zeng, Zexian, Fu, Jingxin, Meyer, Cliff, Zhang, Yi, Cejas, Paloma, Lim, Klothilda, Wang, Jin, Zhang, Wubing, Tokheim, Collin, Sahu, Avinash Das, Xing, Xiaofang, Kroger, Benjamin, Ouyang, Zhangyi, Long, Henry, Freeman, Gordon J, Brown, Myles, Liu, X Shirley

“…Immune checkpoint blockade (ICB) therapy has improved patient survival in a variety of cancers, but only a minority of cancer patients respond. Multiple…”
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Mitochondrial-Targeted Triphenylphosphonium-Hydroxycamptothecin Conjugate and Its Nano-Formulations for Breast Cancer Therapy: In Vitro and In Vivo Investigation by Zhang, Kunfeng, Fu, Jingxin, Liu, Xiaorui, Guo, Yifei, Han, Meihua, Liu, Meifeng, Wang, Xiangtao

“…Mitochondria are involved in various stages of cancer cell diffusion and metastasis. Therefore, targeting tumor mitochondria with antineoplastic medicines to…”
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Improved Therapeutic Efficacy of CBD with Good Tolerance in the Treatment of Breast Cancer through Nanoencapsulation and in Combination with 20(S)-Protopanaxadiol (PPD) by Fu, Jingxin, Zhang, Kunfeng, Lu, Likang, Li, Manzhen, Han, Meihua, Guo, Yifei, Wang, Xiangtao

“…Cannabidiol (CBD), a nonpsychoactive major component derived from Cannabis sativa, widely used in neurodegenerative diseases, has now been proven to have…”
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Immune receptor repertoires in pediatric and adult acute myeloid leukemia by Zhang, Jian, Hu, Xihao, Wang, Jin, Sahu, Avinash Das, Cohen, David, Song, Li, Ouyang, Zhangyi, Fan, Jingyu, Wang, Binbin, Fu, Jingxin, Gu, Shengqing, Sade-Feldman, Moshe, Hacohen, Nir, Li, Wuju, Ying, Xiaomin, Li, Bo, Liu, X Shirley

“…Acute myeloid leukemia (AML), caused by the abnormal proliferation of immature myeloid cells in the blood or bone marrow, is one of the most common hematologic…”
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Soybean lecithin stabilizes disulfiram nanosuspensions with a high drug-loading content: remarkably improved antitumor efficacy by Li, Haowen, Liu, Biao, Ao, Hui, Fu, Jingxin, Wang, Yian, Feng, Yue, Guo, Yifei, Wang, Xiangtao

“…Disulfiram (DSF) has been considered as "Repurposing drug" in cancer therapy in recent years based on its good antitumor efficacy. DSF is traditionally used as…”
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A comparative study on the in vitro and in vivo antitumor efficacy of icaritin and hydrous icaritin nanorods by Li, Haowen, Li, Yijing, Ao, Hui, Fu, Jingxin, Guo, Yifei, Han, Meihua, Yan, Xueying, Chen, Xi, Wang, Xiangtao

“…Icaritin (ICT) and hydrous icaritin (HICT) are two similar flavonoids compounds isolated from Epimedium Genus. This is the first comparative study on their…”
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Hydrous icaritin nanorods with excellent stability improves the in vitro and in vivo activity against breast cancer by Wang, Yian, Huang, Tiantian, Li, Haowen, Fu, Jingxin, Ao, Hui, Lu, Likang, Han, Meihua, Guo, Yifei, Yue, Feng, Wang, Xiangtao

“…Due to their various biological activities that are beneficial to human health and antitumor effect, flavonoid compounds have attracted much attention in…”
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Checkpoint blockade-induced CD8+ T cell differentiation in head and neck cancer responders by Zhou, Liye, Zeng, Zexian, Egloff, Ann Marie, Zhang, Fan, Guo, Fei, Campbell, Katie M, Du, Peter, Fu, Jingxin, Zolkind, Paul, Ma, Xiaojing, Zhang, Zhe, Zhang, Yi, Wang, Xiaoqing, Gu, Shengqing, Riley, Rachel, Nakahori, Yasutaka, Keegan, Joshua, Haddad, Robert, Schoenfeld, Jonathan D, Griffith, Obi, Manguso, Robert T, Lederer, James A, Liu, X Shirley, Uppaluri, Ravindra

“…BackgroundImmune checkpoint blockade (ICB) response in recurrent/metastatic head and neck squamous cell carcinoma (HNSCC) is limited to 15%–20% of patients and…”
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