Search Results - "Fu, Hongjun"
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scGNN is a novel graph neural network framework for single-cell RNA-Seq analyses
Published in Nature communications (25-03-2021)“…Single-cell RNA-sequencing (scRNA-Seq) is widely used to reveal the heterogeneity and dynamics of tissues, organisms, and complex diseases, but its analyses…”
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A shared disease-associated oligodendrocyte signature among multiple CNS pathologies
Published in Nature neuroscience (01-07-2022)“…Alzheimer’s disease (AD) is a complex neurodegenerative disease, perturbing neuronal and non-neuronal cell populations. In this study, using single-cell…”
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Tau Pathology Induces Excitatory Neuron Loss, Grid Cell Dysfunction, and Spatial Memory Deficits Reminiscent of Early Alzheimer’s Disease
Published in Neuron (Cambridge, Mass.) (08-02-2017)“…The earliest stages of Alzheimer’s disease (AD) are characterized by the formation of mature tangles in the entorhinal cortex and disorientation and confusion…”
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Neuronal activity enhances tau propagation and tau pathology in vivo
Published in Nature neuroscience (01-08-2016)“…The authors show that tau can be released by neurons and transferred to other neurons via the extracellular space. Moreover, they show that enhancing neuronal…”
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scREAD: A Single-Cell RNA-Seq Database for Alzheimer's Disease
Published in iScience (20-11-2020)“…Alzheimer's disease (AD) is a progressive neurodegenerative disorder of the brain and the most common form of dementia among the elderly. The single-cell…”
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A single-cell and spatial RNA-seq database for Alzheimer’s disease (ssREAD)
Published in Nature communications (06-06-2024)“…Alzheimer’s Disease (AD) pathology has been increasingly explored through single-cell and single-nucleus RNA-sequencing (scRNA-seq & snRNA-seq) and spatial…”
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Design and Performance Evaluation of Polymer Matrix Composite Helical Springs
Published in Polymers (01-09-2022)“…Helical springs are indispensable mechanical parts widely used in industry. Lightweight is one of the development trends of helical springs. In this study,…”
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Author Correction: scGNN is a novel graph neural network framework for single-cell RNA-Seq analyses
Published in Nature communications (04-05-2022)Get full text
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New unexpected role for Wolfram Syndrome protein WFS1: a novel therapeutic target for Alzheimer's disease?
Published in Neural regeneration research (01-07-2023)Get full text
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Modeling neurodegenerative diseases with cerebral organoids and other three-dimensional culture systems: focus on Alzheimer's disease
Published in Stem cell reviews and reports (01-02-2022)“…Many neurodegenerative diseases (NDs) such as Alzheimer's disease, Parkinson's disease, frontotemporal dementia, amyotrophic lateral sclerosis and Huntington's…”
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Wolframin is a novel regulator of tau pathology and neurodegeneration
Published in Acta neuropathologica (01-05-2022)“…Selective neuronal vulnerability to protein aggregation is found in many neurodegenerative diseases including Alzheimer’s disease (AD). Understanding the…”
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Cardiovascular comorbidities among patients with psoriasis: a national register-based study in China
Published in Scientific reports (24-08-2024)“…This study aims to illustrate epidemiology of comorbid CVD in the real-world clinical setting of patients with psoriasis in China. We used data of adult…”
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Effects of Litsea cubeba Essential Oil-Chitosan/Corn Starch Composite Films on the Quality and Shelf-Life of Strawberry ( Fragaria × ananassa )
Published in Foods (16-02-2024)“…In this work, we have developed a composite chitosan film incorporating the essential oil (LCEO) and starch with good physical properties, and investigated the…”
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Spatially resolved transcriptomics reveals genes associated with the vulnerability of middle temporal gyrus in Alzheimer's disease
Published in Acta neuropathologica communications (21-12-2022)“…Human middle temporal gyrus (MTG) is a vulnerable brain region in early Alzheimer's disease (AD), but little is known about the molecular mechanisms underlying…”
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Global disease burden linked to diet high in red meat and colorectal cancer from 1990 to 2019 and its prediction up to 2030
Published in Frontiers in nutrition (Lausanne) (14-03-2024)“…Numerous studies have already identified an association between excessive consumption of red meat and colorectal cancer (CRC). However, there has been a lack…”
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Carbon fiber composite multistrand helical springs with adjustable spring constant: design and mechanism studies
Published in Journal of materials research and technology (01-05-2020)“…The helical spring is one of the fundamental mechanical elements in a wide range of industrial applications. In this study, a novel helical spring made of…”
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17
Capacity optimization configuration of live gas storage system in independent power systems
Published in International Journal of Thermofluids (01-02-2024)“…As the energy demand and the continuous improvement of environmental performance continuous grow, the use of Independent Power Systems (IPS) is becoming…”
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Use of scREAD to explore and analyze single-cell and single-nucleus RNA-seq data for Alzheimer’s disease
Published in STAR protocols (18-06-2021)“…Single-cell RNA-sequencing (scRNA-seq) and single-nucleus RNA-sequencing (snRNA-seq) studies have provided remarkable insights into understanding the molecular…”
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Calculating the formation period of fault lateral sealing and its application
Published in Energy Geoscience (01-01-2022)“…The study aims to find out the formation period of fault traps near faults in petroliferous basins, based on an analysis of the formation period of fault…”
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Determining effective faults for hydrocarbon accumulation in slope areas of petroliferous basins: Methods and applications
Published in Frontiers in earth science (Lausanne) (10-01-2023)“…From accumulation mechanisms and the identification of effective faults, hydrocarbon distribution in slope areas of petroliferous basins is assessed. In this…”
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