Search Results - "Fu, Buyin"

More homogeneous capillary flow and oxygenation in deeper cortical layers correlate with increased oxygen extraction by Li, Baoqiang, Esipova, Tatiana V, Sencan, Ikbal, Kılıç, Kıvılcım, Fu, Buyin, Desjardins, Michele, Moeini, Mohammad, Kura, Sreekanth, Yaseen, Mohammad A, Lesage, Frederic, Østergaard, Leif, Devor, Anna, Boas, David A, Vinogradov, Sergei A, Sakadžić, Sava

“…Our understanding of how capillary blood flow and oxygen distribute across cortical layers to meet the local metabolic demand is incomplete. We addressed this…”
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Intracranial pressure spikes trigger spreading depolarizations by Oka, Fumiaki, Sadeghian, Homa, Yaseen, Mohammad A, Fu, Buyin, Kura, Sreekanth, Qin, Tao, Sakadžić, Sava, Sugimoto, Kazutaka, Inoue, Takao, Ishihara, Hideyuki, Nomura, Sadahiro, Suzuki, Michiyasu, Ayata, Cenk

“…Spreading depolarizations are highly prevalent and spatiotemporally punctuated events worsening the outcome of brain injury. Trigger factors are poorly…”
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Aerobic exercise reverses aging-induced depth-dependent decline in cerebral microcirculation by Shin, Paul, Pian, Qi, Ishikawa, Hidehiro, Hamanaka, Gen, Mandeville, Emiri T, Guo, Shuzhen, Fu, Buyin, Alfadhel, Mohammed, Allu, Srinivasa Rao, Şencan-Eğilmez, Ikbal, Li, Baoqiang, Ran, Chongzhao, Vinogradov, Sergei A, Ayata, Cenk, Lo, Eng, Arai, Ken, Devor, Anna, Sakadžić, Sava

“…Aging is a major risk factor for cognitive impairment. Aerobic exercise benefits brain function and may promote cognitive health in older adults. However,…”
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Two-photon microscopic imaging of capillary red blood cell flux in mouse brain reveals vulnerability of cerebral white matter to hypoperfusion by Li, Baoqiang, Ohtomo, Ryo, Thunemann, Martin, Adams, Stephen R, Yang, Jing, Fu, Buyin, Yaseen, Mohammad A, Ran, Chongzhao, Polimeni, Jonathan R, Boas, David A, Devor, Anna, Lo, Eng H, Arai, Ken, Sakadžić, Sava

“…Despite the importance of understanding the regulation of microvascular blood flow in white matter, no data on subcortical capillary blood flow parameters are…”
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Fluorescence lifetime microscopy of NADH distinguishes alterations in cerebral metabolism in vivo by Yaseen, Mohammad A, Sutin, Jason, Wu, Weicheng, Fu, Buyin, Uhlirova, Hana, Devor, Anna, Boas, David A, Sakadžić, Sava

“…Evaluating cerebral energy metabolism at microscopic resolution is important for comprehensively understanding healthy brain function and its pathological…”
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Phasor analysis of NADH FLIM identifies pharmacological disruptions to mitochondrial metabolic processes in the rodent cerebral cortex by Gómez, Carlos A, Sutin, Jason, Wu, Weicheng, Fu, Buyin, Uhlirova, Hana, Devor, Anna, Boas, David A, Sakadžić, Sava, Yaseen, Mohammad A

“…Investigating cerebral metabolism in vivo at a microscopic level is essential for understanding brain function and its pathological alterations. The intricate…”
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Measurements of cerebral microvascular blood flow, oxygenation, and morphology in a mouse model of whole-brain irradiation-induced cognitive impairment by two-photon microscopy and optical coherence tomography: evidence for microvascular injury in the cerebral white matter by Li, Baoqiang, Yabluchanskiy, Andriy, Tarantini, Stefano, Allu, Srinivasa Rao, Şencan-Eğilmez, Ikbal, Leng, Ji, Alfadhel, Mohammed Ali H., Porter, Jason E., Fu, Buyin, Ran, Chongzhao, Erdener, Sefik Evren, Boas, David A., Vinogradov, Sergei A., Sonntag, William E., Csiszar, Anna, Ungvari, Zoltan, Sakadžić, Sava

“…Whole-brain irradiation (WBI, also known as whole-brain radiation therapy) is a mainstay treatment modality for patients with multiple brain metastases. It is…”
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Capillary red blood cell velocimetry by phase-resolved optical coherence tomography by Tang, Jianbo, Erdener, Sefik Evren, Fu, Buyin, Boas, David A

“…We present a phase-resolved optical coherence tomography (OCT) method to extend Doppler OCT for the accurate measurement of the red blood cell (RBC) velocity…”
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Quantifying Intestinal Capillary Oxygenation Using Two‐photon Phosphorescence Lifetime Microscopy by Sencan, Ikbal, Zong, Wenjing, Alfadhel, Mohammed, Fu, Buyin, Yaseen, Mohammed, Wu, Gary, Sakadzic, Sava, Vinogradov, Sergei

“…Impaired oxygen delivery reduces the diversity of the gut microbiota1,2. Quantifying the microvascular oxygenation in the small intestines may help us better…”
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Optical measurement of microvascular oxygenation and blood flow responses in awake mouse cortex during functional activation by Şencan, İkbal, Esipova, Tatiana, Kılıç, Kıvılcım, Li, Baoqiang, Desjardins, Michèle, Yaseen, Mohammad A, Wang, Hui, Porter, Jason E, Kura, Sreekanth, Fu, Buyin, Secomb, Timothy W, Boas, David A, Vinogradov, Sergei A, Devor, Anna, Sakadžić, Sava

“…The cerebral cortex has a number of conserved morphological and functional characteristics across brain regions and species. Among them, the laminar…”
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Optical coherence tomography imaging of capillary reperfusion after ischemic stroke by Lee, Jonghwan, Gursoy-Ozdemir, Yasemin, Fu, Buyin, Boas, David A, Dalkara, Turgay

“…Although progress has been made for recanalization therapies after ischemic stroke, post-treatment imaging studies show that tissue reperfusion cannot be…”
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Out-of-focus signal rejection for in vivo pO₂ measurements using two-photon phosphorescence lifetime microscopy by Pian, Qi, Li, Baoqiang, Sencan-Egilmez, Ikbal, Cheng, Xiaojun, Dubb, Jay, HUANG, XINYUE, Fu, Buyin, Rao Allu, Srinivasa, Yaseen, Abbas, Devor, Anna, Vinogradov, Sergei, Sakadzic, Sava

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Cortical microvascular blood flow velocity mapping by combining dynamic light scattering optical coherence tomography and two-photon microscopy by Pian, Qi, Alfadhel, Mohammed, Tang, Jianbo, Lee, Grace V, Li, Baoqiang, Fu, Buyin, Ayata, Yagmur, Yaseen, Mohammad Abbas, Boas, David A, Secomb, Timothy W, Sakadzic, Sava

“…The accurate large-scale mapping of cerebral microvascular blood flow velocity is crucial for a better understanding of cerebral blood flow (CBF) regulation…”
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Shear‐induced diffusion of red blood cells measured with dynamic light scattering‐optical coherence tomography by Tang, Jianbo, Erdener, Sefik Evren, Li, Baoqiang, Fu, Buyin, Sakadzic, Sava, Carp, Stefan A., Lee, Jonghwan, Boas, David A.

“…Quantitative measurements of intravascular microscopic dynamics, such as absolute blood flow velocity, shear stress and the diffusion coefficient of red blood…”
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Two-photon phosphorescence lifetime microscopy of retinal capillary plexus oxygenation in mice by Şencan, İkbal, Esipova, Tatiana V, Yaseen, Mohammad A, Fu, Buyin, Boas, David A, Vinogradov, Sergei A, Shahidi, Mahnaz, Sakadžić, Sava

“…Impaired oxygen delivery and/or consumption in the retinal tissue underlies the pathophysiology of many retinal diseases. However, the essential tools for…”
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Impact of temporal resolution on estimating capillary RBC-flux with optical coherence tomography by Li, Baoqiang, Wang, Hui, Fu, Buyin, Wang, Ruopeng, Sakadžić, Sava, Boas, David A

“…Optical coherence tomography (OCT) has been used to measure capillary red blood cell (RBC) flux. However, one important technical issue is that the accuracy of…”
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Quantitation of cerebral oxygen tension using phasor analysis and phosphorescence lifetime imaging microscopy (PLIM) by Liu, Chang, Chisholm, Amanda, Fu, Buyin, Su, Clover T-Y, Şencan, İkbal, Sakadžić, Sava, Yaseen, Mohammad A

“…Time-domain measurements for fluorescence lifetime imaging microscopy (FLIM) and phosphorescence lifetime imaging microscopy (PLIM) are conventionally computed…”
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Differential reductions in the capillary red-blood-cell flux between retina and brain under chronic global hypoperfusion by Li, Baoqiang, Leng, Ji, Şencan-Eğilmez, Ikbal, Takase, Hajime, Alfadhel, Mohammed Ali H, Fu, Buyin, Shahidi, Mahnaz, Lo, Eng H, Arai, Ken, Sakadžić, Sava

“…It has been hypothesized that abnormal microcirculation in the retina might predict the risk of ischemic damages in the brain. Direct comparison between the…”
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Cerebral metabolism in a mouse model of Alzheimer's disease characterized by two-photon fluorescence lifetime microscopy of intrinsic NADH by Gómez, Carlos A, Fu, Buyin, Sakadžić, Sava, Yaseen, Mohammad A

“…Disruptions and alterations to cerebral energy metabolism play a vital role in the onset and progression of many neurodegenerative disorders and cerebral…”
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Abstract 5329: Blocking multiple coinhibitory pathways for immunotherapy of established melanoma by Cai, Guifang, Xia, Bu, Fu, Buyin, Freeman, Gordon J.

“…Abstract Previous studies have shown that coinhibitory molecules like PD-L1 and B7-H3 are upregulated on a variety of tumor cells and high expression…”
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