Search Results - "Fryer, T. D."

Combined magnetic resonance imaging and positron emission tomography brain imaging in behavioural variant frontotemporal degeneration: refining the clinical phenotype by Kipps, C. M., Hodges, J. R., Fryer, T. D., Nestor, P. J.

“…In patients with the behavioural variant of frontotemporal dementia, prognosis is often surprisingly good when there is normal structural imaging at…”
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Imaging atherosclerotic plaque inflammation with [18F]-fluorodeoxyglucose positron emission tomography by RUDD, J. H. F, WARBURTON, E. A, PICKARD, J. D, WEISSBERG, P. L, FRYER, T. D, JONES, H. A, CLARK, J. C, ANTOUN, N, JOHNSTRÖM, P, DAVENPORT, A. P, KIRKPATRICK, P. J, ARCH, B. N

“…Atherosclerotic plaque rupture is usually a consequence of inflammatory cell activity within the plaque. Current imaging techniques provide anatomic data but…”
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Orbitofrontal dopamine depletion upregulates caudate dopamine and alters behavior via changes in reinforcement sensitivity by Clarke, H F, Cardinal, R N, Rygula, R, Hong, Y T, Fryer, T D, Sawiak, S J, Ferrari, V, Cockcroft, G, Aigbirhio, F I, Robbins, T W, Roberts, A C

“…Schizophrenia is associated with upregulation of dopamine (DA) release in the caudate nucleus. The caudate has dense connections with the orbitofrontal cortex…”
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Retrosplenial cortex (BA 29/30) hypometabolism in mild cognitive impairment (prodromal Alzheimer's disease) by Nestor, P. J., Fryer, T. D., Ikeda, M., Hodges, J. R.

“…Previous group studies using positron emission tomography to assess resting cerebral glucose metabolism in very early Alzheimer's disease and mild cognitive…”
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The topography of metabolic deficits in posterior cortical atrophy (the visual variant of Alzheimer’s disease) with FDG-PET by Nestor, P J, Caine, D, Fryer, T D, Clarke, J, Hodges, J R

“…Background:The term “posterior cortical atrophy” (PCA) refers to a clinical syndrome in which higher order visual processing is disrupted owing to a…”
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Selective neuronal loss in rescued penumbra relates to initial hypoperfusion by Guadagno, J. V., Jones, P. S., Aigbirhio, F. I., Wang, D., Fryer, T. D., Day, D. J., Antoun, N., Nimmo-Smith, I., Warburton, E. A., Baron, J. C.

“…Selective neuronal loss (SNL) in the rescued penumbra could account for suboptimal clinical recovery despite effective early reperfusion. Previous studies of…”
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Physiological thresholds for irreversible tissue damage in contusional regions following traumatic brain injury by Cunningham, A. S., Salvador, R., Coles, J. P., Chatfield, D. A., Bradley, P. G., Johnston, A. J., Steiner, L. A., Fryer, T. D., Aigbirhio, F. I., Smielewski, P., Williams, G. B., Carpenter, T. A., Gillard, J. H., Pickard, J. D., Menon, D. K.

“…Cerebral ischaemia appears to be an important mechanism of secondary neuronal injury in traumatic brain injury (TBI) and is an important predictor of outcome…”
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How affected is oxygen metabolism in DWI lesions? : A combined acute stroke PET-MR study by GUADAGNO, J. V, WARBURTON, E. A, GILLARD, J. H, BARON, J.-C, JONES, P. S, DAY, D. J, AIGBIRHIO, F. I, FRYER, T. D, HARDING, S, PRICE, C. J, GREEN, H. A, BARRET, O

“…To use back-to-back diffusion-weighted imaging (DWI) and PET to obtain quantitative measures of the cerebral metabolic rate of oxygen (CMRO(2)) within DWI…”
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Development of a Combined microPET®-MR System by Lucas, A. J., Hawkes, R. C., Ansorge, R. E., Williams, G. B., Nutt, R. E., Clark, J. C., Fryer, T. D., Carpenter, T. A.

“…As evidenced by the success of PET-CT, there are many benefits from combining imaging modalities into a single scanner. The combination of PET and MR offers…”
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Nuclear imaging can predict pathologic diagnosis in progressive nonfluent aphasia by NESTOR, P. J, BALAN, K, CHEOW, H. K, FRYER, T. D, KNIBB, J. A, XUEREB, J. H, HODGES, J. R

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A microPET study of the regional distribution of [11C]-PK11195 binding following temporary focal cerebral ischemia in the rat. Correlation with post mortem mapping of microglia activation by Hughes, J.L., Jones, P.S., Beech, J.S., Wang, D., Menon, D.K., Aigbirhio, F.I., Fryer, T.D., Baron, J.C.

“…Post-stroke microglial activation (MA) may have both neurotoxic and pro-repair effects, particularly in the salvaged penumbra. Mapping MA in vivo is therefore…”
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Neurometabolic coupling in the vegetative and minimally conscious states: preliminary findings by Coleman, M R, Menon, D K, Fryer, T D, Pickard, J D

“…The objective of this study was to determine the integrity of the homoeostatic coupling relationship between neuronal electrical function and cerebral…”
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Imaging regional variation of cellular proliferation in gliomas using 3′-deoxy-3′-[18 F]fluorothymidine positron-emission tomography: an image-guided biopsy study by Price, S.J, Fryer, T.D, Cleij, M.C, Dean, A.F, Joseph, J, Salvador, R, Wang, D.D, Hutchinson, P.J, Clark, J.C, Burnet, N.G, Pickard, J.D, Aigbirhio, F.I, Gillard, J.H

“…Aim To compare regional variations in uptake of 3′-deoxy-3′- [18 F]-fluorothymidine (FLT) images using positron-emission tomography (PET) with measures of…”
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What the left and right anterior fusiform gyri tell us about semantic memory by Mion, Marco, Patterson, Karalyn, Acosta-Cabronero, Julio, Pengas, George, Izquierdo-Garcia, David, Hong, Young T., Fryer, Tim D., Williams, Guy B., Hodges, John R., Nestor, Peter J.

“…The study of patients with semantic dementia, a variant of frontotemporal lobar degeneration, has emerged over the last two decades as an important lesion…”
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Atrophy, hypometabolism and white matter abnormalities in semantic dementia tell a coherent story by Acosta-Cabronero, Julio, Patterson, Karalyn, Fryer, Tim D., Hodges, John R., Pengas, George, Williams, Guy B., Nestor, Peter J.

“…Semantic dementia, in which there is progressive deterioration of semantic knowledge, is associated with focal, typically asymmetric, temporal lobe…”
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Cerebrovascular pressure reactivity is related to global cerebral oxygen metabolism after head injury by Steiner, L A, Coles, J P, Czosnyka, M, Minhas, P S, Fryer, T D, Aigbirhio, F I, Clark, J C, Smielewski, P, Chatfield, D A, Donovan, T, Pickard, J D, Menon, D K

“…Background: After head injury, impaired cerebrovascular autoregulation has been associated with abnormally high or low cerebral blood flow. The physiological…”
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Neuroinflammatory and morphological changes in late-life depression: the NIMROD study by Su, Li, Faluyi, Yetunde O., Hong, Young T., Fryer, Tim D., Mak, Elijah, Gabel, Silvy, Hayes, Lawrence, Soteriades, Soteris, Williams, Guy B., Arnold, Robert, Passamonti, Luca, Rodríguez, Patricia Vázquez, Surendranathan, Ajenthan, Bevan-Jones, Richard W., Coles, Jonathan, Aigbirhio, Franklin, Rowe, James B., O'Brien, John T.

“…We studied neuroinflammation in individuals with late-life, depression, as a risk factor for dementia, using [11C]PK11195 positron emission tomography (PET)…”
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Acceleration of motion-compensated PET reconstruction: ordered subsets-gates EM algorithms and a priori reference gate information by Dikaios, N, Fryer, T D

“…Patient motion during positron emission tomography scans leads to significant resolution loss and image degradation. Motion-compensated image reconstruction…”
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Glucose metabolism in traumatic brain injury: a combined microdialysis and [18F]-2-fluoro-2-deoxy-D-glucose-positron emission tomography (FDG-PET) study by O'Connell, M T, Seal, A, Nortje, J, Al-Rawi, P G, Coles, J P, Fryer, T D, Menon, D K, Pickard, J D, Hutchinson, P J

“…Following traumatic brain injury, as a consequence of ionic disturbances and neurochemical cascades, glucose metabolism is affected…”
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Progressive non‐fluent aphasia is associated with hypometabolism centred on the left anterior insula by Nestor, Peter J., Graham, Naida L., Fryer, Tim D., Williams, Guy B., Patterson, Karalyn, Hodges, John R.

“…Progressive non‐fluent aphasia (PNFA) is a syndrome in which patients lose the ability to communicate fluently in the context of relative preservation of…”
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