Search Results - "Fryer, Andrew M"

Discovery of (1S,2R,3R)-2,3-Dimethyl-2-phenyl-1-sulfamidocyclopropanecarboxylates: Novel and Highly Selective Aggrecanase Inhibitors by Shiozaki, Makoto, Maeda, Katsuya, Miura, Tomoya, Kotoku, Masayuki, Yamasaki, Takayuki, Matsuda, Isamu, Aoki, Kenta, Yasue, Katsutaka, Imai, Hiroto, Ubukata, Minoru, Suma, Akira, Yokota, Masahiro, Hotta, Takahiro, Tanaka, Masahiro, Hase, Yasunori, Haas, Julia, Fryer, Andrew M, Laird, Ellen R, Littmann, Nicole M, Andrews, Steven W, Josey, John A, Mimura, Takayuki, Shinozaki, Yuichi, Yoshiuchi, Hiromi, Inaba, Takashi

“…Aggrecanases, particularly aggrecanase-1 (ADAMTS-4) and aggrecanase-2 (ADAMTS-5), are believed to be key enzymes involved in the articular cartilage breakdown…”
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A New Resin-Bound Universal Isonitrile for the Ugi 4CC Reaction:  Preparation and Applications to the Synthesis of 2,5-Diketopiperazines and 1,4-Benzodiazepine-2,5-diones by Kennedy, April L, Fryer, Andrew M, Josey, John A

“…The preparation and synthetic applications of a novel resin-bound isonitrile are described. The resin is an example of a novel convertible isonitrile that can…”
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Applications of Vinylogous Mannich Reactions. Total Syntheses of the Ergot Alkaloids Rugulovasines A and B and Setoclavine by Liras, Spiros, Lynch, Christopher L, Fryer, Andrew M, Vu, Binh T, Martin, Stephen F

“…Concise syntheses of the Ergot alkaloids rugulovasine A (3a), rugulovasine B (3b), and setoclavine (2) have been completed by strategies that feature inter-…”
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Novel N-substituted 2-phenyl-1-sulfonylamino-cyclopropane carboxylates as selective ADAMTS-5 (Aggrecanase-2) inhibitors by SHIOZAKI, Makoto, MAEDA, Katsuya, MIMURA, Takayuki, SHINOZAKI, Yuichi, YOSHIUCHI, Hiromi, INABA, Takashi, MIURA, Tomoya, OGOSHI, Yosuke, HAAS, Julia, FRYER, Andrew M, LAIRD, Ellen R, LITTMANN, Nicole M, ANDREWS, Steven W, JOSEY, John A

“…A series of N-substituted sulfonylamino-alkanecarboxylate ADAMTS-5 (Aggrecanase-2) inhibitors has been synthesized and the in vitro enzyme SAR is discussed…”
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Synthesis and SAR of 2-phenyl-1-sulfonylaminocyclopropane carboxylates as ADAMTS-5 (Aggrecanase-2) inhibitors by Shiozaki, Makoto, Imai, Hiroto, Maeda, Katsuya, Miura, Tomoya, Yasue, Katsutaka, Suma, Akira, Yokota, Masahiro, Ogoshi, Yosuke, Haas, Julia, Fryer, Andrew M., Laird, Ellen R., Littmann, Nicole M., Andrews, Steven W., Josey, John A., Mimura, Takayuki, Shinozaki, Yuichi, Yoshiuchi, Hiromi, Inaba, Takashi

“…A series of 1-sulfonylaminocyclopropanecarboxylates was synthesized as ADAMTS-5 (Aggrecanase-2) inhibitors. After an intensive investigation of the central…”
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Parallel Synthesis of Novel Heteroaromatic Acromelic Acid Analogues from Kainic Acid by Baldwin, Jack E, Fryer, Andrew M, Pritchard, Gareth J

“…A range of new C-4 heteroaromatic acromelic acid analogues has been synthesized in a parallel fashion from (−)-α-kainic acid 1. Protection of the amine and…”
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Towards a versatile synthesis of kainoids I: Introduction of the C-3 and C-4 substituents by Baldwin, Jack E., Bamford, Samantha J., Fryer, Andrew M., Rudolph, Martin P.W., Wood, Mark E.

“…The first stages in the synthesis of acromelic acid analogues from trans-4-hydroxy- L -proline are described. An enamine alkylation was used to…”
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1H NMR Study of Protected and Unprotected Kainoid Amino Acids:  Facile Assignment of C-4 Stereochemistry by Baldwin, Jack E, Fryer, Andrew M, Pritchard, Gareth J

“…The kainoid amino acids exhibit potent neuroexcitatory activity in the mammalian central nervous system. Around their pyrrolidine ring, a trans disposition…”
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A biomimetic approach to the pyridone rings of the acromelic acids: A concise synthesis of acromelic acid A and an approach to acromelic acid B by Baldwin, Jack E., Fryer, Andrew M., Pritchard, Gareth J., Spyvee, Mark R., Whitehead, Roger C., Wood, Mark E.

“…The syntheses of acromelic acid A 1, allo-acromelic acid A 19 and an approach towards acromelic acid B 2 are described. Palladium (0) catalysed cross-coupling…”
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Towards a versatile synthesis of kainoids II: Two methods for establishment of C-4 stereochemistry by Baldwin, Jack E., Bamford, Samantha J., Fryer, Andrew M., Rudolph, Martin P.W., Wood, Mark E.

“…Benzylic lactone hydrogenolysis and enamide reduction were used to generate protected C-4 aryl substituted kainoid analogues which were deprotected to their…”
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Concise syntheses of acromelic acid A and allo-acromelic acid A by Baldwin, Jack E., Fryer, Andrew M., Pritchard, Gareth J., Spyvee, Mark R., Whitehead, Roger C., Wood, Mark.E.

“…Acromelic acid A 1 and allo-acromelic acid A 12 were synthesised in a biomimetic fashion. An oxidative cleavage - recyclisation strategy was used to construct…”
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Stereocontrol in the synthesis of kainoids by Baldwin, Jack E, Fryer, Andrew M, Spyvee, Mark R, Whitehead, Roger C, Wood, Mark E

“…A stereoselective synthesis of acromelic acid analogues is described in which the C-3 C-4 cis-relative stereochemistry is established by a hydroxyl directed…”
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1 H NMR Study of Protected and Unprotected Kainoid Amino Acids:  Facile Assignment of C-4 Stereochemistry by Baldwin, Jack E., Fryer, Andrew M., Pritchard, Gareth J.

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Novel C-4 heteroaromatic kainoid analogues : A parallel synthesis approach by BALDWIN, J. E, FRYER, A. M, PRITCHARD, G. J

“…New C-4 thiazole 4, 5 and aminothiazole 6, 7 kainoid analogues were efficiently synthesised in five steps from commercially available (-)-alpha-kainic acid I…”
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Towards a versatile synthesis of kainoids III: Efficient methods for control of C-4 stereochemistry by Baldwin, Jack E., Fryer, Andrew M., Spyvee, Mark R., Whitehead, Roger C., Wood, Mark E.

“…Halo- and selenolactonisation methods were used to prepare benzylic lactones from enamide carboxylic acids. The lactones were subsequently cleaved with…”
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A Versatile Approach to Acromelic Acid Analogues by Baldwin, J

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A versatile approach to acromelic acid analogues by Baldwin, Jack E., Bamford, Samantha J., Fryer, Andrew M., Wood, Mark E.

“…A route to acromelic acid analogues and their corresponding C-4 epimers from trans-4-hydroxy- L -proline is described. The C-4 substituent was introduced by a…”
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