Search Results - "Frye, R F"

Pharmacometabolomic Assessments of Atenolol and Hydrochlorothiazide Treatment Reveal Novel Drug Response Phenotypes by Rotroff, DM, Shahin, MH, Gurley, SB, Zhu, H, Motsinger‐Reif, A, Meisner, M, Beitelshees, AL, Fiehn, O, Johnson, JA, Elbadawi‐Sidhu, M, Frye, RF, Gong, Y, Weng, L, Cooper‐DeHoff, RM, Kaddurah‐Daouk, R

“…Achieving hypertension (HTN) control and mitigating the adverse health effects associated with HTN continues to be a global challenge. Some individuals respond…”
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The effect of trimethoprim on CYP2C8 mediated rosiglitazone metabolism in human liver microsomes and healthy subjects by Hruska, M. W., Amico, J. A., Langaee, T. Y., Ferrell, R. E., Fitzgerald, S. M., Frye, R. F.

“…Aims Rosiglitazone, a thiazolidinedione antidiabetic medication used in the treatment of Type 2 diabetes mellitus, is predominantly metabolized by the…”
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DHEA and DHEA-S: A Review by Kroboth, Patricia D., Salek, Firoozeh S., Pittenger, Amy L., Fabian, Tanya J., Frye, Reginald F.

“…Dehydroepiandrosterone (DHEA) and its sulfated metabolite DHEA‐S are endogenous hormones secreted by the adrenal cortex in response to adrenocorticotrophin…”
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Evaluation of flurbiprofen urinary ratios as in vivo indices for CYP2C9 activity by Zgheib, N. K., Frye, R. F., Tracy, T. S., Romkes, M., Branch, R. A.

“…Aims We investigated flurbiprofen pharmacokinetics in 12 volunteers to develop a phenotypic trait measure that correlates with the fractional clearance to…”
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Validation of the five-drug "Pittsburgh cocktail" approach for assessment of selective regulation of drug-metabolizing enzymes by Frye, Reginald F., Matzke, Gary R., Adedoyin, Adedayo, Porter, James A., Branch, Robert A.

“…Objectives To determine whether the probe drugs caffeine, chlorzoxazone, dapsone, debrisoquin (INN, debrisoquine), and mephenytoin can be simultaneously…”
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Concentration‐dependent response to pioglitazone in nonalcoholic steatohepatitis by Kawaguchi‐Suzuki, M., Bril, F., Kalavalapalli, S., Cusi, K., Frye, R. F.

“…Summary Background Pioglitazone is a safe and effective option to manage patients with type 2 diabetes and nonalcoholic steatohepatitis (NASH). However, there…”
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Determinants of vancomycin clearance by continuous venovenous hemofiltration and continuous venovenous hemodialysis by Joy, MS, Matzke, GR, Frye, RF, Palevsky, PM

“…The clearance of vancomycin is significantly reduced in patients with acute, as well as, chronic renal failure. Although multiple-dosage regimen adjustment…”
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Drug administration in patients with renal insufficiency : Minimising renal and extrarenal toxicity by MATZKE, G. R, FRYE, R. F

“…Renal insufficiency has been associated with an increased risk of adverse effects with many classes of medications. The risk of some, but not all, adverse…”
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Pharmacokinetics of intermittent intraperitoneal ceftazidime by Grabe, Darren W., Bailie, George R., Eisele, George, Frye, Reginald F.

“…Ceftazidime is currently recommended as an alternative first-line agent in the treatment of peritonitis and for Pseudomonas peritonitis. The pharmacokinetics…”
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Chloroquine modulation of specific metabolizing enzymes activities: investigation with selective five drug cocktail by Adedoyin, Adedayo, Frye, Reginald F., Mauro, Kelly, Branch, Robert A.

“…Aims  The aim of this study was to investigate whether chloroquine can inhibit drug metabolism in humans, if such inhibition is general or selective for…”
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Evaluation of the Influence of Diabetes Mellitus on Antipyrine Metabolism and CYP1A2 and CYP2D6 Activity by Matzke, Gary R., Frye, Reginald F., Early, John J., Straka, Robert J., Carson, Stanley W.

“…Study Objective. To evaluate the metabolism of antipyrine, a general metabolic probe, caffeine, a probe for cytochrome P450 (CYP) 1A2 and N‐acetyltransferase…”
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Cefazolin as empiric therapy in hemodialysis-related infections: Efficacy and blood concentrations by Marx, MA, Frye, RF, Matzke, GR, Golper, TA

“…Concern about the increasing incidence of vancomycin-resistant organisms has tempered the enthusiasm for indiscriminate vancomycin use. Cefazolin has an…”
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Determinants of Ceftriaxone Clearance by Continuous Venovenous Hemofiltration and Hemodialysis by Matzke, Gary R., Frye, Reginald F., Joy, Melanie S., Palevsky, Paul M.

“…Study Objective. To guide individual ceftriaxone dosages in patients receiving continuous renal replacement therapy. Design. Prospective, outpatient study…”
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Effect of Ceftazidime on Systemic Cytokine Concentrations in Rats by ALKHARFY, Khalid M, KELLUM, John A, FRYE, Reginald F, MATZKE, Gary R

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Sex Differences in the Pharmacokinetics of Dehydroepiandrosterone (DHEA) after Single- and Multiple-Dose Administration in Healthy Older Adults by Frye, Reginald F., Kroboth, Patricia D., Kroboth, Frank J., Stone, Roslyn A., Folan, Maggie, Salek, Firoozeh S., Pollock, Bruce G., Linares, Ana M., Hakala, Charles

“…The pharmacokinetics of exogenously administered DHEA have not been well characterized despite its increasing use in therapeutic and research investigations…”
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Intravenous vancomycin pharmacokinetics in automated peritoneal dialysis patients by Manley, HJ, Bailie, GR, Frye, RF, McGoldrick, MD

“…School of Pharmacy, University of Missouri-Kansas City, USA. ManleyH@UMKC.edu…”
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Pharmacokinetics of intraperitoneal cefazolin and ceftazidime coadministered to CAPD patients by Elwell, R J, Manley, H J, Frye, R F, Bailie, G R

“…Guidelines for empiric treatment of PD-related peritonitis published in 2000 recommend concurrent intraperitoneal (IP) cefazolin and ceftazidime. The…”
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Effect of valerian, valerian/hops extracts, and valerenic acid on glucuronidation in vitro by Alkharfy, K. M., Frye, R. F.

“…Valerian preparations alone or in combination with hops are popular over-the-counter products used for sleep disturbances or anxiety. Therefore, it is…”
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Pharmacokinetics of intermittent intraperitoneal cefazolin in continuous ambulatory peritoneal dialysis patients by Manley, HJ, Bailie, GR, Asher, RD, Eisele, G, Frye, RF

“…Albany College of Pharmacy, New York 12208, USA…”
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The effect of age on the pharmacokinetics of the opioid antagonist nalmefene by FRYE, R. F., MATZKE, G. R., JALLAD, N. S., WILHELM, J. A., BIKHAZI, G. B.

“…1The disposition of nalmefene was evaluated in young and elderly normal healthy volunteers. Subjects received either a single 1 mg (n=18 young; n=11 elderly)…”
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