Search Results - "Frye, Jeremiah J."

Mechanism of Polyubiquitination by Human Anaphase-Promoting Complex: RING Repurposing for Ubiquitin Chain Assembly by Brown, Nicholas G., Watson, Edmond R., Weissmann, Florian, Jarvis, Marc A., VanderLinden, Ryan, Grace, Christy R.R., Frye, Jeremiah J., Qiao, Renping, Dube, Prakash, Petzold, Georg, Cho, Shein Ei, Alsharif, Omar, Bao, Ju, Davidson, Iain F., Zheng, Jie J., Nourse, Amanda, Kurinov, Igor, Peters, Jan-Michael, Stark, Holger, Schulman, Brenda A.

“…Polyubiquitination by E2 and E3 enzymes is a predominant mechanism regulating protein function. Some RING E3s, including anaphase-promoting complex/cyclosome…”
Get full text

ProteoPlex: stability optimization of macromolecular complexes by sparse-matrix screening of chemical space by Chari, Ashwin, Haselbach, David, Kirves, Jan-Martin, Ohmer, Juergen, Paknia, Elham, Fischer, Niels, Ganichkin, Oleg, Möller, Vanessa, Frye, Jeremiah J, Petzold, Georg, Jarvis, Marc, Tietzel, Michael, Grimm, Clemens, Peters, Jan-Michael, Schulman, Brenda A, Tittmann, Kai, Markl, Jürgen, Fischer, Utz, Stark, Holger

“…ProteoPlex optimizes buffer conditions for the isolation and purification of macromolecular complexes. The concurrent complex stabilization is beneficial for…”
Get full text

RING E3 mechanism for ubiquitin ligation to a disordered substrate visualized for human anaphase-promoting complex by Brown, Nicholas G., VanderLinden, Ryan, Watson, Edmond R., Qiao, Renping, Grace, Christy R. R., Yamaguchi, Masaya, Weissmann, Florian, Frye, Jeremiah J., Dube, Prakash, Cho, Shein Ei, Actis, Marcelo L., Rodrigues, Patrick, Fujii, Naoaki, Peters, Jan-Michael, Stark, Holger, Schulman, Brenda A.

“…Significance The anaphase-promoting complex/cyclosome (APC) is a multisubunit RING E3 ubiquitin (Ub) ligase that regulates mitosis, meiosis, and numerous…”
Get full text

Structure of an APC3–APC16 Complex: Insights into Assembly of the Anaphase-Promoting Complex/Cyclosome by Yamaguchi, Masaya, Yu, Shanshan, Qiao, Renping, Weissmann, Florian, Miller, Darcie J., VanderLinden, Ryan, Brown, Nicholas G., Frye, Jeremiah J., Peters, Jan-Michael, Schulman, Brenda A.

“…The anaphase-promoting complex/cyclosome (APC/C) is a massive E3 ligase that controls mitosis by catalyzing ubiquitination of key cell cycle regulatory…”
Get full text

Structure-Function Analysis of the C-terminal Domain of CNM67, a Core Component of the Saccharomyces cerevisiae Spindle Pole Body by Klenchin, Vadim A., Frye, Jeremiah J., Jones, Michele H., Winey, Mark, Rayment, Ivan

“…The spindle pole body of the budding yeast Saccharomyces cerevisiae has served as a model system for understanding microtubule organizing centers, yet very…”
Get full text

Insights into the Importance of Hydrogen Bonding in the γ-Phosphate Binding Pocket of Myosin: Structural and Functional Studies of Serine 236 by Frye, Jeremiah J, Klenchin, Vadim A, Bagshaw, Clive R, Rayment, Ivan

“…The active site of myosin contains a group of highly conserved amino acid residues whose roles in nucleotide hydrolysis and energy transduction might appear to…”
Get full text

Electron microscopy structure of human APC/CCDH1–EMI1 reveals multimodal mechanism of E3 ligase shutdown by Frye, Jeremiah J, Brown, Nicholas G, Petzold, Georg, Watson, Edmond R, Grace, Christy R R, Nourse, Amanda, Jarvis, Marc A, Kriwacki, Richard W, Peters, Jan-Michael, Stark, Holger, Schulman, Brenda A

“…APC/C is an E3 ligase complex of ~1.5 MDa that regulates cell division. APC/C CDH1 is inhibited during interphase by EMI1. Now, NMR spectroscopy, electron…”
Get full text

Insights into the Importance of Hydrogen Bonding in the [gamma]-Phosphate Binding Pocket of Myosin: Structural and Functional Studies of Serine 236 by Frye, Jeremiah J., Klenchin, Vadim A., Bagshaw, Clive R., Rayment, Ivan

“…The active site of myosin contains a group of highly conserved amino acid residues whose roles in nucleotide hydrolysis and energy transduction might appear to…”
Get full text

Electron microscopy structure of human APC/[C.sup.CDH1]-EMI1 reveals multimodal mechanism of E3 ligase shutdown by Frye, Jeremiah J, Brown, Nicholas G, Petzold, Georg, Watson, Edmond R, Grace, Christy R.R, Nourse, Amanda, Jarvis, Marc A, Kriwacki, Richard W, Peters, Jan-Michael, Stark, Holger, Schulman, Brenda A

“…The anaphase-promoting complex/cyclosome (APC/C) is a ~1.5-MDa multiprotein E3 ligase enzyme that regulates cell division by promoting timely…”
Get full text

EM Structure of human APC/CCDH1-EMI1 reveals multimodal mechanism of E3 ligase shutdown by Frye, Jeremiah J., Brown, Nicholas G., Petzold, Georg, Watson, Edmond R., Grace, Christy R. R., Nourse, Amanda, Jarvis, Marc A., Kriwacki, Richard W., Peters, Jan-Michael, Stark, Holger, Schulman, Brenda A.

“…The Anaphase Promoting Complex/Cyclosome (APC/C) is a ~1.5 MDa multiprotein E3 ligase enzyme that regulates cell division by promoting timely…”
Get full text

Novel approaches to stabilizing and crystallizing coiled-coil containing proteins by Frye, Jeremiah J

“…Structural studies of proteins is an active area of research that has grown steadily over the last 60 years. The number of proteins with structural solutions…”
Get full text

Electron microscopy structure of human APC/C(CDH1)-EMI1 reveals multimodal mechanism of E3 ligase shutdown by Frye, Jeremiah J, Brown, Nicholas G, Petzold, Georg, Watson, Edmond R, Grace, Christy R R, Nourse, Amanda, Jarvis, Marc A, Kriwacki, Richard W, Peters, Jan-Michael, Stark, Holger, Schulman, Brenda A

“…The anaphase-promoting complex/cyclosome (APC/C) is a ~1.5-MDa multiprotein E3 ligase enzyme that regulates cell division by promoting timely…”
Get full text

Novel approaches to stabilizing and crystallizing coiled-coil containing proteins by Frye, Jeremiah J

“…Structural studies of proteins is an active area of research that has grown steadily over the last 60 years. The number of proteins with structural solutions…”
Get full text