Search Results - "Frycia, Anne"

Discovery of 4-Substituted Pyrrolidone Butanamides as New Agents with Significant Antiepileptic Activity by Kenda, Benoit M, Matagne, Alain C, Talaga, Patrice E, Pasau, Patrick M, Differding, Edmond, Lallemand, Bénédicte I, Frycia, Anne M, Moureau, Florence G, Klitgaard, Henrik V, Gillard, Michel R, Fuks, Bruno, Michel, Philippe

“…(S)-α-ethyl-2-oxopyrrolidine acetamide 2 (levetiracetam, Keppra, UCB S.A.), a structural analogue of piracetam, has recently been approved as an add-on…”
Get full text

Towards a KCC2 blocker pharmacophore model by Lebon, Florence, Pégurier, Cécile, Ledecq, Marie, Mathieu, Benoit, Bosman, Nathalie, Frycia, Anne, Lengelé, Sébastien, Dhurke, Kashinath, Kanduluru, Ananda Kumar, Meunier, Stéphane, Wagner, Alain, Wolff, Christian, Provins, Laurent

“…The first pharmacophore model for KCC2 blockers was identified using a multi-disciplinary approach combining molecular modelling techniques, XRD, NMR, SAR…”
Get full text

Discovery of Indolone Acetamides as Novel SV2A Ligands with Improved Potency Toward Seizure Suppression by Frycia, Anne, Starck, Jean-Philippe, Jadot, Sophie, Lallemand, Bénédicte, Leclercq, Karine, Lo Brutto, Patrick, Matagne, Alain, Verbois, Valérie, Mercier, Joël, Kenda, Benoit

“…Capitalizing on the proven clinical efficacy of levetiracetam as an antiepileptic drug, a drug discovery program lead to the identification of a new generation…”
Get full text

Cover Picture: Discovery of Indolone Acetamides as Novel SV2A Ligands with Improved Potency Toward Seizure Suppression (ChemMedChem 2/2010) by Frycia, Anne, Starck, Jean-Philippe, Jadot, Sophie, Lallemand, Bénédicte, Leclercq, Karine, Lo Brutto, Patrick, Matagne, Alain, Verbois, Valérie, Mercier, Joël, Kenda, Benoit

Get full text

Conformational restriction of Tyr and Phe side chains in opioid peptides: Information about preferred and bioactive side-chain topology by Tourwé, Dirk, Verschueren, Kris, Frycia, Anne, Davis, Peg, Porreca, Frank, Hruby, Victor J., Toth, Geza, Jaspers, Hendrika, Verheyden, Patricia, Van Binst, Georges

“…The side chain of Tyr and Phe was fixed into the gauche (−) or gauche (+) conformation by using the Tic or Htc structures, and into the trans conformation by…”
Get full text