Search Results - "Fry, Elizabeth E."

Target Identification and Mode of Action of Four Chemically Divergent Drugs against Ebolavirus Infection by Ren, Jingshan, Zhao, Yuguang, Fry, Elizabeth E, Stuart, David I

“…Here, we show that four chemically divergent approved drugs reported to inhibit Ebolavirus infection, benztropine, bepridil, paroxetine and sertraline,…”
Get full text

Neutralization of SARS-CoV-2 by Destruction of the Prefusion Spike by Huo, Jiandong, Zhao, Yuguang, Ren, Jingshan, Zhou, Daming, Duyvesteyn, Helen M.E., Ginn, Helen M., Carrique, Loic, Malinauskas, Tomas, Ruza, Reinis R., Shah, Pranav N.M., Tan, Tiong Kit, Rijal, Pramila, Coombes, Naomi, Bewley, Kevin R., Tree, Julia A., Radecke, Julika, Paterson, Neil G., Supasa, Piyada, Mongkolsapaya, Juthathip, Screaton, Gavin R., Carroll, Miles, Townsend, Alain, Fry, Elizabeth E., Owens, Raymond J., Stuart, David I.

“…There are as yet no licensed therapeutics for the COVID-19 pandemic. The causal coronavirus (SARS-CoV-2) binds host cells via a trimeric spike whose receptor…”
Get full text

Hepatitis A virus and the origins of picornaviruses by Wang, Xiangxi, Ren, Jingshan, Gao, Qiang, Hu, Zhongyu, Sun, Yao, Li, Xuemei, Rowlands, David J., Yin, Weidong, Wang, Junzhi, Stuart, David I., Rao, Zihe, Fry, Elizabeth E.

“…Hepatitis A virus is a picornavirus that causes significant morbidity but remains poorly understood; this paper now provides high-resolution crystal structures…”
Get full text

Near-atomic structure of Japanese encephalitis virus reveals critical determinants of virulence and stability by Wang, Xiangxi, Li, Shi-Hua, Zhu, Ling, Nian, Qing-Gong, Yuan, Shuai, Gao, Qiang, Hu, Zhongyu, Ye, Qing, Li, Xiao-Feng, Xie, Dong-Yang, Shaw, Neil, Wang, Junzhi, Walter, Thomas S., Huiskonen, Juha T., Fry, Elizabeth E., Qin, Cheng-Feng, Stuart, David I., Rao, Zihe

“…Although several different flaviviruses may cause encephalitis, Japanese encephalitis virus is the most significant, being responsible for thousands of deaths…”
Get full text

Plant-made polio type 3 stabilized VLPs—a candidate synthetic polio vaccine by Marsian, Johanna, Fox, Helen, Bahar, Mohammad W., Kotecha, Abhay, Fry, Elizabeth E., Stuart, David I., Macadam, Andrew J., Rowlands, David J., Lomonossoff, George P.

“…Poliovirus (PV) is the causative agent of poliomyelitis, a crippling human disease known since antiquity. PV occurs in two distinct antigenic forms, D and C,…”
Get full text

A sensor-adaptor mechanism for enterovirus uncoating from structures of EV71 by Wang, Xiangxi, Peng, Wei, Ren, Jingshan, Hu, Zhongyu, Xu, Jiwei, Lou, Zhiyong, Li, Xumei, Yin, Weidong, Shen, Xinliang, Porta, Claudine, Walter, Thomas S, Evans, Gwyndaf, Axford, Danny, Owen, Robin, Rowlands, David J, Wang, Junzhi, Stuart, David I, Fry, Elizabeth E, Rao, Zihe

“…Enterovirus 71 (EV71) is a major agent of hand, foot and mouth disease in children, but no vaccine or antiviral therapy is available. Structural analysis of…”
Get full text

Rational engineering of recombinant picornavirus capsids to produce safe, protective vaccine antigen by Porta, Claudine, Kotecha, Abhay, Burman, Alison, Jackson, Terry, Ren, Jingshan, Loureiro, Silvia, Jones, Ian M, Fry, Elizabeth E, Stuart, David I, Charleston, Bryan

“…Foot-and-mouth disease remains a major plague of livestock and outbreaks are often economically catastrophic. Current inactivated virus vaccines require…”
Get full text

The antibody response to SARS-CoV-2 Beta underscores the antigenic distance to other variants by Liu, Chang, Zhou, Daming, Nutalai, Rungtiwa, Duyvesteyn, Helen M.E., Tuekprakhon, Aekkachai, Ginn, Helen M., Dejnirattisai, Wanwisa, Supasa, Piyada, Mentzer, Alexander J., Wang, Beibei, Case, James Brett, Zhao, Yuguang, Skelly, Donal T., Chen, Rita E., Johnson, Sile Ann, Ritter, Thomas G., Mason, Chris, Malik, Tariq, Temperton, Nigel, Paterson, Neil G., Williams, Mark A., Hall, David R., Clare, Daniel K., Howe, Andrew, Goulder, Philip J.R., Fry, Elizabeth E., Diamond, Michael S., Mongkolsapaya, Juthathip, Ren, Jingshan, Stuart, David I., Screaton, Gavin R.

“…Alpha-B.1.1.7, Beta-B.1.351, Gamma-P.1, and Delta-B.1.617.2 variants of SARS-CoV-2 express multiple mutations in the spike protein (S). These may alter the…”
Get full text

Rules of engagement between αvβ6 integrin and foot-and-mouth disease virus by Kotecha, Abhay, Wang, Quan, Dong, Xianchi, Ilca, Serban L., Ondiviela, Marina, Zihe, Rao, Seago, Julian, Charleston, Bryan, Fry, Elizabeth E., Abrescia, Nicola G. A., Springer, Timothy A., Huiskonen, Juha T., Stuart, David I.

“…Foot-and-mouth disease virus (FMDV) mediates cell entry by attachment to an integrin receptor, generally αvβ6, via a conserved arginine–glycine–aspartic acid…”
Get full text

Nonlytic cellular release of hepatitis A virus requires dual capsid recruitment of the ESCRT-associated Bro1 domain proteins HD-PTP and ALIX by Shirasaki, Takayoshi, Feng, Hui, Duyvesteyn, Helen M E, Fusco, William G, McKnight, Kevin L, Xie, Ling, Boyce, Mark, Kumar, Sathish, Barouch-Bentov, Rina, González-López, Olga, McNamara, Ryan, Wang, Li, Hertel-Wulff, Adriana, Chen, Xian, Einav, Shirit, Duncan, Joseph A, Kapustina, Maryna, Fry, Elizabeth E, Stuart, David I, Lemon, Stanley M

“…Although picornaviruses are conventionally considered 'nonenveloped', members of multiple picornaviral genera are released nonlytically from infected cells in…”
Get full text

Structure-Based in Silico Screening Identifies a Potent Ebolavirus Inhibitor from a Traditional Chinese Medicine Library by Shaikh, Faraz, Zhao, Yuguang, Alvarez, Luis, Iliopoulou, Maria, Lohans, Christopher, Schofield, Christopher J, Padilla-Parra, Sergi, Siu, Shirley W. I, Fry, Elizabeth E, Ren, Jingshan, Stuart, David I

“…Potent Ebolavirus (EBOV) inhibitors will help to curtail outbreaks such as that which occurred in 2014–16 in West Africa. EBOV has on its surface a single…”
Get full text

Hand-foot-and-mouth disease virus receptor KREMEN1 binds the canyon of Coxsackie Virus A10 by Zhao, Yuguang, Zhou, Daming, Ni, Tao, Karia, Dimple, Kotecha, Abhay, Wang, Xiangxi, Rao, Zihe, Jones, E. Yvonne, Fry, Elizabeth E., Ren, Jingshan, Stuart, David I.

“…Coxsackievirus A10 (CV-A10) is responsible for an escalating number of severe infections in children, but no prophylactics or therapeutics are currently…”
Get full text

Picornavirus uncoating intermediate captured in atomic detail by Ren, Jingshan, Wang, Xiangxi, Hu, Zhongyu, Gao, Qiang, Sun, Yao, Li, Xuemei, Porta, Claudine, Walter, Thomas S., Gilbert, Robert J., Zhao, Yuguang, Axford, Danny, Williams, Mark, McAuley, Katherine, Rowlands, David J., Yin, Weidong, Wang, Junzhi, Stuart, David I., Rao, Zihe, Fry, Elizabeth E.

“…It remains largely mysterious how the genomes of non-enveloped eukaryotic viruses are transferred across a membrane into the host cell. Picornaviruses are…”
Get full text

The SARS-CoV-2 neutralizing antibody response to SD1 and its evasion by BA.2.86 by Zhou, Daming, Supasa, Piyada, Liu, Chang, Dijokaite-Guraliuc, Aiste, Duyvesteyn, Helen M. E., Selvaraj, Muneeswaran, Mentzer, Alexander J., Das, Raksha, Dejnirattisai, Wanwisa, Temperton, Nigel, Klenerman, Paul, Dunachie, Susanna J., Fry, Elizabeth E., Mongkolsapaya, Juthathip, Ren, Jingshan, Stuart, David I., Screaton, Gavin R.

“…Under pressure from neutralising antibodies induced by vaccination or infection the SARS-CoV-2 spike gene has become a hotspot for evolutionary change, leading…”
Get full text

Tandem fusion of hepatitis B core antigen allows assembly of virus-like particles in bacteria and plants with enhanced capacity to accommodate foreign proteins by Peyret, Hadrien, Gehin, Annick, Thuenemann, Eva C, Blond, Donatienne, El Turabi, Aadil, Beales, Lucy, Clarke, Dean, Gilbert, Robert J C, Fry, Elizabeth E, Stuart, David I, Holmes, Kris, Stonehouse, Nicola J, Whelan, Mike, Rosenberg, William, Lomonossoff, George P, Rowlands, David J

“…The core protein of the hepatitis B virus, HBcAg, assembles into highly immunogenic virus-like particles (HBc VLPs) when expressed in a variety of heterologous…”
Get full text

Emerging variants develop total escape from potent monoclonal antibodies induced by BA.4/5 infection by Liu, Chang, Das, Raksha, Dijokaite-Guraliuc, Aiste, Zhou, Daming, Mentzer, Alexander J., Supasa, Piyada, Selvaraj, Muneeswaran, Duyvesteyn, Helen M. E., Ritter, Thomas G., Temperton, Nigel, Klenerman, Paul, Dunachie, Susanna J., Paterson, Neil G., Williams, Mark A., Hall, David R., Fry, Elizabeth E., Mongkolsapaya, Juthathip, Ren, Jingshan, Stuart, David I., Screaton, Gavin R.

“…The rapid evolution of SARS-CoV-2 is driven in part by a need to evade the antibody response in the face of high levels of immunity. Here, we isolate spike (S)…”
Get full text

Structural and functional analysis of protective antibodies targeting the threefold plateau of enterovirus 71 by Huang, Kuan-Ying A., Zhou, Daming, Fry, Elizabeth E., Kotecha, Abhay, Huang, Peng-Nien, Yang, Shu-Li, Tsao, Kuo-Chien, Huang, Yhu-Chering, Lin, Tzou-Yien, Ren, Jingshan, Stuart, David I.

“…Enterovirus 71 (EV71)-neutralizing antibodies correlate with protection and have potential as therapeutic agents. We isolate and characterize a panel of…”
Get full text

A plate-based high-throughput assay for virus stability and vaccine formulation by Walter, Thomas S., Ren, Jingshan, Tuthill, Tobias J., Rowlands, David J., Stuart, David I., Fry, Elizabeth E.

“…► A plate-based assay for virus measuring virus stability. ► Two fluorescent dyes measure independently but simultaneously capsid stability and capsid protein…”
Get full text

Neutralization Mechanisms of Two Highly Potent Antibodies against Human Enterovirus 71 by Zhu, Ling, Xu, Kangwei, Wang, Nan, Cao, Lei, Wu, Junlan, Gao, Qiang, Fry, Elizabeth E, Stuart, David I, Rao, Zihe, Wang, Junzhi, Wang, Xiangxi

“…Despite significant advances in health care, outbreaks of infections by enteroviruses (EVs) continue to plague the Asia-Pacific region every year. Enterovirus…”
Get full text

Neutralization of SARS-CoV-2 by Destruction of the Prefusion Spike by Huo, Jiandong, Zhao, Yuguang, Ren, Jingshan, Zhou, Daming, Duyvesteyn, Helen M.E., Ginn, Helen M., Carrique, Loic, Malinauskas, Tomas, Ruza, Reinis R., Shah, Pranav N.M., Tan, Tiong Kit, Rijal, Pramila, Coombes, Naomi, Bewley, Kevin R., Tree, Julia A., Radecke, Julika, Paterson, Neil G., Supasa, Piyada, Mongkolsapaya, Juthathip, Screaton, Gavin R., Carroll, Miles, Townsend, Alain, Fry, Elizabeth E., Owens, Raymond J., Stuart, David I.

Get full text