Search Results - "Fry, Dennis"

Validation of Diacyl Glycerolacyltransferase I as a Novel Target for the Treatment of Obesity and Dyslipidemia Using a Potent and Selective Small Molecule Inhibitor by Zhao, Gang, Souers, Andrew J, Voorbach, Martin, Falls, H. Doug, Droz, Brian, Brodjian, Sevan, Lau, Yau Yi, Iyengar, Rajesh R, Gao, Ju, Judd, Andrew S, Wagaw, Seble H, Ravn, Matthew M, Engstrom, Kenneth M, Lynch, John K, Mulhern, Mathew M, Freeman, Jennifer, Dayton, Brian D, Wang, Xiaojun, Grihalde, Nelson, Fry, Dennis, Beno, David W. A, Marsh, Kennan C, Su, Zhi, Diaz, Gilbert J, Collins, Christine A, Sham, Hing, Reilly, Regina M, Brune, Michael E, Kym, Philip R

“…A highly potent and selective DGAT-1 inhibitor was identified and used in rodent models of obesity and postprandial chylomicron excursion to validate DGAT-1…”
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Characterization of ghrelin receptor activity in a rat pituitary cell line RC-4B/C by Falls, H Douglas, Dayton, Brian D, Fry, Dennis G, Ogiela, Christopher A, Schaefer, Verlyn G, Brodjian, Sevan, Reilly, Regina M, Collins, Christine A, Kaszubska, Wiweka

“…Ghrelin, a 28 amino acid, octanoylated peptide, is an endogenous ligand for the growth hormone secretagogue receptor (GHS-R). In addition to various endocrine…”
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Characterization of a neuronal cell line expressing native human melanin-concentrating hormone receptor 1 (MCHR1) by Fry, Dennis, Dayton, Brian, Brodjian, Sevan, Ogiela, Christopher, Sidorowicz, Hanna, Frost, Leigh J., McNally, Teresa, Reilly, Regina M., Collins, Christine A.

“…Melanin-concentrating hormone (MCH), an orexigenic neuropeptide in mammals, activates a G-protein coupled receptor, MCHR1. It is expected that antagonists of…”
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Synthesis and evaluation of 2-amino-8-alkoxy quinolines as MCHr1 antagonists. Part 3 by Souers, Andrew J., Wodka, Dariusz, Gao, Ju, Lewis, Jared C., Vasudevan, Anil, Brodjian, Sevan, Dayton, Brian, Ogiela, Christopher A., Fry, Dennis, Hernandez, Lisa E., Marsh, Kennan C., Collins, Christine A., Kym, Philip R.

“…A series of potent and highly CNS penetrable melanin-concentrating hormone inhibitors is described. Prior SAR studies on 2-amino-8-alkoxyquinoline MCHr1…”
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Discovery of Inhibitors of Cell Adhesion Molecule Expression in Human Endothelial Cells. 1. Selective Inhibition of ICAM-1 and E-Selectin Expression by Stewart, Andrew O, Bhatia, Pramila A, McCarty, Catherine M, Patel, Meena V, Staeger, Michael A, Arendsen, David L, Gunawardana, Indrani W, Melcher, Laura M, Zhu, Gui-Dong, Boyd, Steven A, Fry, Dennis G, Cool, Barbara L, Kifle, Lemma, Lartey, Kraig, Marsh, Kennan C, Kempf-Grote, Anita J, Kilgannon, Patrick, Wisdom, Wendy, Meyer, Joey, Gallatin, W. Michael, Okasinski, Gregory F

“…A critical early event in the inflammatory cascade is the induced expression of cell adhesion molecules on the lumenal surface of vascular endothelial cells…”
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Selective Inhibition of ICAM-1 and E-Selectin Expression in Human Endothelial Cells. 2. Aryl Modifications of 4-(Aryloxy)thieno[2,3-c]pyridines with Fine-Tuning at C-2 Carbamides by Zhu, Gui-Dong, Arendsen, David L, Gunawardana, Indrani W, Boyd, Steven A, Stewart, Andrew O, Fry, Dennis G, Cool, Barbara L, Kifle, Lemma, Schaefer, Verlyn, Meuth, Joseph, Marsh, Kennan C, Kempf-Grote, Anita J, Kilgannon, Patrick, Gallatin, W. Michael, Okasinski, Gregory F

“…The elevated expression of cell adhesion molecules (CAMs) on the lumenal surface of vascular endothelial cells is a critical early event in the complex…”
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Stellarex Drug-Coated Balloon for Treatment of Femoropopliteal Disease: Twelve-Month Outcomes From the Randomized ILLUMENATE Pivotal and Pharmacokinetic Studies by Krishnan, Prakash, Faries, Peter, Niazi, Khusrow, Jain, Ash, Sachar, Ravish, Bachinsky, William B, Cardenas, Joseph, Werner, Martin, Brodmann, Marianne, Mustapha, J A, Mena-Hurtado, Carlos, Jaff, Michael R, Holden, Andrew H, Lyden, Sean P, Mewissen, Mark, Katzen, Barry, Nanjundappa, Aravinda, Khuddus, Matheen A, Ricci, Jason, Fry, Dennis, Shishehbor, Mehdi, Bosarge, Christopher, Kovach, Richard, Goodwin, Mark, Raja, Mohammad Laiq, Mayeda, Guy, Sandhu, Jasvinder, Rosales, Oscar, Crowder, William, Paolini, David, Henretta, John, Desai, Pratik, Farhat, Naim, Kang, Edward, Ansel, Gary, Ghani, Mohammad, Miller, William, Pollock, Christopher, Korngold, Ethan, Angle, John F, Schultz, Greg, Gensler, Todd, Lopez, Louis, Park, James, Al-Khoury, Georges, Joels, Charles, Metzger, Christopher

“…BACKGROUND:Drug-coated balloons (DCBs) are a predominant revascularization therapy for symptomatic femoropopliteal artery disease. Because of the differences…”
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Five-year results of the INSPIRATION study for the INCRAFT low-profile endovascular aortic stent graft system by Liang, Nathan L., Ohki, Takao, Ouriel, Kenneth, Teigen, Corey, Fry, Dennis, Henretta, John, Komori, Kimihiro, Kichikawa, Kimihiko, Makaroun, Michel S.

“…We present the 5-year results of a prospective regulatory study of the INCRAFT device, a low-profile endovascular stent graft system for repair of abdominal…”
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Abstract 482: Tipping the balance in the tumor microenvironment: An engineered cytokine (NKTR-214) with altered IL2 receptor binding selectivity and improved efficacy by Charych, Deborah, Lee, Steven, Addepalli, Murali, Chang, Thomas, Kirk, Peter, Konakova, Marina, Vanderveen, Laurie, Kanhere, Rupesh, Fry, Dennis, Ali, Cherie, Harrison, Stephen, Kantak, Seema, Doberstein, Stephen

“…Abstract Introduction Immunotherapy offers the potential for durable responses in a growing list of cancer indications.1 One approach towards stimulating the…”
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Abstract 2465: A new polymer conjugated taxane shows improved efficacy in tumor xenograft models by Fry, Dennis G., Brew, Christine, Lee, Steve, Hoch, Ute, Zhang, Wen, Kozlowski, Antoni, Dahhani, Fadil, Tangudu, Nagabhusan, Harrison, Stephen D., Riggs-Sauthier, Jennifer

“…Abstract Introduction: Microtubule inhibitors are a mainstay of cancer therapy despite limitations in efficacy and tolerability. Such deficiencies are typical…”
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A novel stimulus, oncogene, induces expression of CD80 (B7-1) gene by Zhang, H, Haasch, D, Patterson, B, Dickinson, B, Kifle, L, Fry, D G, Okasinski, G F

“…CD80, a cell surface molecule found on antigen-presenting cells which particpates in costimulatory signaling, is frequently detected on transformed and tumor…”
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Carotid endarterectomy in sapphire-eligible high-risk patients: implications for selecting patients for carotid angioplasty and stenting by Mozes, Geza, Sullivan, Timothy M, Torres-Russotto, Diego R, Bower, Thomas C, Hoskin, Tanya L, Sampaio, Sergio M, Gloviczki, Peter, Panneton, Jean M, Noel, Audra A, Cherry, Kenneth J

“…Carotid angioplasty and stenting (CAS) has been proposed as an alternative to carotid endarterectomy (CEA) in patients excluded from the North American…”
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Etirinotecan pegol (EP) target-specific pharmacodynamic (PD) biomarkers measured in circulating tumor cells (CTCs) from patients in the phase III BEACON study in patients with metastatic breast cancer (mBC) by Hoch, Ute, Fry, Dennis G., Chia, Yen Lin, Caygill, Katie, Hannah, Alison L., Perez, Edith A., Cortez, Javier, Awada, Ahmad, O'Shaughnessy, Joyce, Twelves, Christopher, Rugo, Hope S., Im, Seock-Ah, Xu, Binghe, Anderes, Kenna Lynn, Davis, Darren W.

“…Abstract only 1087 Background: EP is a unique topoisomerase 1 inhibitor that provides continuous exposure to SN38. EP demonstrated a 29% overall response rate…”
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Morphological transformation, focus formation, and anchorage independence induced in diploid human fibroblasts by expression of a transfected H-ras oncogene by HURLIN, P. J, FRY, D. G, MAHER, V. M, MCCORMICK, J. J

“…In an attempt to determine how normal human fibroblasts respond to high expression of the T24 H-ras oncogene, we tranfected such cells with the plasmid vector…”
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Discovery and Characterization of Aminopiperidinecoumarin Melanin Concentrating Hormone Receptor 1 Antagonists by Kym, Philip R, Iyengar, Rajesh, Souers, Andrew J, Lynch, John K, Judd, Andrew S, Gao, Ju, Freeman, Jennifer, Mulhern, Mathew, Zhao, Gang, Vasudevan, Anil, Wodka, Dariusz, Blackburn, Christopher, Brown, Jim, Che, Jennifer Lee, Cullis, Courtney, Lai, Su Jen, LaMarche, Matthew J, Marsilje, Tom, Roses, Jon, Sells, Todd, Geddes, Brad, Govek, Elizabeth, Patane, Michael, Fry, Dennis, Dayton, Brian D, Brodjian, Sevan, Falls, Doug, Brune, Michael, Bush, Eugene, Shapiro, Robin, Knourek-Segel, Victoria, Fey, Thomas, McDowell, Cathleen, Reinhart, Glenn A, Preusser, Lee C, Marsh, Kennan, Hernandez, Lisa, Sham, Hing L, Collins, Christine A

“…4-(1-Benzo[1,3]dioxol-5-ylmethylpiperidine-4-ylmethyl)-6-chlorochromen-2-one (7) is a potent, orally bioavailable melanin concentrating hormone receptor 1…”
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Endovascular Repair of a Blunt Traumatic Axillary Artery Injury Presenting with Limb-Threatening Ischemia by Papaconstantinou, Harry T., Fry, Dennis M., Giglia, Joseph, Hurst, James, Edwards, John D.

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Synthesis and evaluation of 2-amino-8-alkoxy quinolines as MCHr1 antagonists. Part 2 by Vasudevan, Anil, Wodka, Dariusz, Verzal, Mary K., Souers, Andrew J., Gao, Ju, Brodjian, Sevan, Fry, Dennis, Dayton, Brian, Marsh, Kennan C., Hernandez, Lisa E., Ogiela, Christopher A., Collins, Christine A., Kym, Philip R.

“…Melanin concentrating hormone (MCHr1) antagonists containing heteroatoms in the substituent at the 8-position, which demonstrate picomolar binding affinities…”
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Synthesis and evaluation of 2-amino-8-alkoxy quinolines as MCHr1 antagonists. Part 1 by Souers, Andrew J., Wodka, Dariusz, Gao, Ju, Lewis, Jared C., Vasudevan, Anil, Gentles, Robert, Brodjian, Sevan, Dayton, Brian, Ogiela, Christopher A., Fry, Dennis, Hernandez, Lisa E., Marsh, Kennan C., Collins, Christine A., Kym, Philip R.

“…Hit-to-lead investigation of a 2-amino-8-alkoxy quinoline containing high throughput screening hit is described. A high-throughput screen was performed in…”
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The effect of changes in cell geometry on the sensitivity to ultraviolet radiation of mammalian cellular capacity by Coohill, T P, Knauer, D J, Fry, D G

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Carotid endarterectomy in SAPPHIRE-eligible high-risk patients: Implications for selecting patients for carotid angioplasty and stenting. Discussion by MOZES, Geza, SULLIVAN, Timothy M, FRY, Dennis, JACOBS, Donald, SULLIVAN, Timothy, RICOTTA, John J, TORRES-RUSSOTTO, Diego R, BOWER, Thomas C, HOSKIN, Tanya L, SAMPAIO, Sergio M, GLOVICZKI, Peter, PANNETON, Jean M, NOEL, Audra A, CHERRY, Kenneth J

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