Search Results - "Frushour, Brian P."

Small molecule activators of SIRT1 replicate signaling pathways triggered by calorie restriction in vivo by Smith, Jesse J, Kenney, Renée Deehan, Gagne, David J, Frushour, Brian P, Ladd, William, Galonek, Heidi L, Israelian, Kristine, Song, Jeffrey, Razvadauskaite, Giedre, Lynch, Amy V, Carney, David P, Johnson, Robin J, Lavu, Siva, Iffland, Andre, Elliott, Peter J, Lambert, Philip D, Elliston, Keith O, Jirousek, Michael R, Milne, Jill C, Boss, Olivier

“…Calorie restriction (CR) produces a number of health benefits and ameliorates diseases of aging such as type 2 diabetes. The components of the pathways…”
Get full text

The Role of Hypoxia in 2-Butoxyethanol–Induced Hemangiosarcoma by Laifenfeld, Daphna, Gilchrist, Annalyn, Drubin, David, Jorge, Milena, Eddy, Sean F., Frushour, Brian P., Ladd, Bill, Obert, Leslie A., Gosink, Mark M., Cook, Jon C., Criswell, Kay, Somps, Christopher J., Koza-Taylor, Petra, Elliston, Keith O., Lawton, Michael P.

“…To understand the molecular mechanisms underlying compound-induced hemangiosarcomas in mice, and therefore, their human relevance, a systems biology approach…”
Get full text

A parA Homolog Selectively Influences Positioning of the Large Chromosome Origin in Vibrio cholerae by SAINT-DIC, Djenann, FRUSHOUR, Brian P, KEHRL, Jason H, LYN SUE KAHNG

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Quantitative assessment of biological impact using transcriptomic data and mechanistic network models by Thomson, Ty M., Sewer, Alain, Martin, Florian, Belcastro, Vincenzo, Frushour, Brian P., Gebel, Stephan, Park, Jennifer, Schlage, Walter K., Talikka, Marja, Vasilyev, Dmitry M., Westra, Jurjen W., Hoeng, Julia, Peitsch, Manuel C.

“…Exposure to biologically active substances such as therapeutic drugs or environmental toxicants can impact biological systems at various levels, affecting…”
Get full text

A computable cellular stress network model for non-diseased pulmonary and cardiovascular tissue by Schlage, Walter K, Westra, Jurjen W, Gebel, Stephan, Catlett, Natalie L, Mathis, Carole, Frushour, Brian P, Hengstermann, Arnd, Van Hooser, Aaron, Poussin, Carine, Wong, Ben, Lietz, Michael, Park, Jennifer, Drubin, David, Veljkovic, Emilija, Peitsch, Manuel C, Hoeng, Julia, Deehan, Renee

“…Humans and other organisms are equipped with a set of responses that can prevent damage from exposure to a multitude of endogenous and environmental stressors…”
Get full text

Construction of a computable cell proliferation network focused on non-diseased lung cells by Westra, Jurjen W, Schlage, Walter K, Frushour, Brian P, Gebel, Stephan, Catlett, Natalie L, Han, Wanjiang, Eddy, Sean F, Hengstermann, Arnd, Matthews, Andrea L, Mathis, Carole, Lichtner, Rosemarie B, Poussin, Carine, Talikka, Marja, Veljkovic, Emilija, Van Hooser, Aaron A, Wong, Benjamin, Maria, Michael J, Peitsch, Manuel C, Deehan, Renee, Hoeng, Julia

“…Critical to advancing the systems-level evaluation of complex biological processes is the development of comprehensive networks and computational methods to…”
Get full text

An algorithm for score aggregation over causal biological networks based on random walk sampling by Vasilyev, Dmitry M, Thomson, Ty M, Frushour, Brian P, Martin, Florian, Sewer, Alain

“…We recently published in BMC Systems Biology an approach for calculating the perturbation amplitudes of causal network models by integrating gene differential…”
Get full text

Early patient stratification and predictive biomarkers in drug discovery and development: a case study of ulcerative colitis anti-TNF therapy by Laifenfeld, Daphna, Drubin, David A, Catlett, Natalie L, Park, Jennifer S, Van Hooser, Aaron A, Frushour, Brian P, de Graaf, David, Fryburg, David A, Deehan, Renée

“…The current drug discovery paradigm is long, costly, and prone to failure. For projects in early development, lack of efficacy in Phase II is a major…”
Get more information

W1777 Excess Seqa Causes a DNA Replication Arrest in Vibrio Cholerae, and Heterologous Overexpression Experiments Show That Lethality Is Specific to V. Cholerae by Saint-Dic, Djenann, Kehrl, Jason H, Frushour, Brian P, Kahng, Lyn Sue

Get full text

Abstract 4132: Predictive classifiers for response to c-Met targeted therapies in lung and colon cancer by Drubin, David, Catlett, Natalie L., Park, Jennifer, Van Hooser, Aaron A., Frushour, Brian P., Kenney, Renee Deehan

“…Abstract A fundamental challenge in the development of cancer therapies is the co-development of companion biomarkers to select patients most likely to respond…”
Get full text