Search Results - "Frum, Rebecca A."

Mechanisms of mutant p53 stabilization in cancer by Frum, Rebecca A, Grossman, Steven R

“…p53 transactivates cell cycle inhibitory, apoptosis or senescence-related genes in response to DNA damage to protect the genetic integrity of the cell…”
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Temporal differences in DNA replication during the S phase using single fiber analysis of normal human fibroblasts and glioblastoma T98G cells by Frum, Rebecca A., Khondker, Zakaria S., Kaufman, David G.

“…We have recently shown that replication forks pause near origins in normal human fibroblasts (NHF1-hTERT) but not glioblastoma T98G cells.  This observation…”
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Mutant p53 establishes targetable tumor dependency by promoting unscheduled replication by Singh, Shilpa, Vaughan, Catherine A, Frum, Rebecca A, Grossman, Steven R, Deb, Sumitra, Palit Deb, Swati

“…Gain-of-function (GOF) p53 mutations are observed frequently in most intractable human cancers and establish dependency for tumor maintenance and progression…”
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DNA replication in early S phase pauses near newly activated origins by Frum, Rebecca A., Chastain II, Paul D., Qu, Pingping, Cohen, Stephanie M., Kaufman, David G.

“…During the S phase of the cell cycle, the entire genome is replicated. There is a high level of orderliness to this process through the temporally and…”
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Constitutive Activation of DNA Damage Checkpoint Signaling Contributes to Mutant p53 Accumulation via Modulation of p53 Ubiquitination by Frum, Rebecca A, Love, Ian M, Damle, Priyadarshan K, Mukhopadhyay, Nitai D, Palit Deb, Swati, Deb, Sumitra, Grossman, Steven R

“…Many mutant p53 proteins exhibit an abnormally long half-life and overall increased abundance compared with wild-type p53 in tumors, contributing to mutant…”
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Use of the DNA fiber spreading technique to detect the effects of mutant p53 on DNA replication by Frum, Rebecca A, Deb, Sumitra, Deb, Swati Palit

“…DNA replication involves a coordinated progression through S phase, and disruption of these regulated steps may cause gene abnormalities, which may lead to…”
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The human oncoprotein MDM2 induces replication stress eliciting early intra-S-phase checkpoint response and inhibition of DNA replication origin firing by Frum, Rebecca A, Singh, Shilpa, Vaughan, Catherine, Mukhopadhyay, Nitai D, Grossman, Steven R, Windle, Brad, Deb, Sumitra, Deb, Swati Palit

“…Conventional paradigm ascribes the cell proliferative function of the human oncoprotein mouse double minute2 (MDM2) primarily to its ability to degrade p53…”
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The RP-p53-Mdm2 pathway: A new link to genetic integrity? by Frum, Rebecca A., Zhang, Yanping

“…Comment on: Llanos S, et al. Cell Cycle 2010; 9:4005-12…”
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The RP-p53-Mdm2 pathway: A new link to genetic integrity?: Comment on: Llanos S, et al. Cell Cycle 2010; 9:4005–12 by Frum, Rebecca A, Zhang, Yanping

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Role of MDM2 in cell growth regulation by Frum, Rebecca A

“…MDM2 has been shown to induce G0-G1/S phase arrest. To determine the cell cycle step targeted by MDM2, flow cytometry was employed to detect induction of…”
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Temporal and functional analysis of DNA replicated in early S phase by Kaufman, David G., Cohen, Stephanie M., Chastain, Paul D.

“…In summary, recently developed technologies have begun to draw back the curtain of mystery that obscures some of the basic mechanisms of DNA replication at…”
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