Search Results - "Fruen, Bradley R"

Cardiac myocyte Z-line calmodulin is mainly RyR2-bound, and reduction is arrhythmogenic and occurs in heart failure by Yang, Yi, Guo, Tao, Oda, Tetsuro, Chakraborty, Asima, Chen, Le, Uchinoumi, Hitoshi, Knowlton, Anne A, Fruen, Bradley R, Cornea, Razvan L, Meissner, Gerhard, Bers, Donald M

“…Calmodulin (CaM) associates with cardiac ryanodine receptor type-2 (RyR2) as an important regulator. Defective CaM-RyR2 interaction may occur in heart failure,…”
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Kinetics of FKBP12.6 Binding to Ryanodine Receptors in Permeabilized Cardiac Myocytes and Effects on Ca Sparks by Guo, Tao, Cornea, Razvan L, Huke, Sabine, Camors, Emmanuel, Yang, Yi, Picht, Eckard, Fruen, Bradley R, Bers, Donald M

“…RATIONALE:FK506-binding proteins FKBP12.6 and FKBP12 are associated with cardiac ryanodine receptors (RyR2), and cAMP-dependent protein kinase A…”
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FRET Detection of Calmodulin Binding to the Cardiac RyR2 Calcium Release Channel by Guo, Tao, Fruen, Bradley R., Nitu, Florentin R., Nguyen, Trinh D., Yang, Yi, Cornea, Razvan L., Bers, Donald M.

“…Calmodulin (CaM) binding to the type 2 ryanodine receptor (RyR2) regulates Ca release from the cardiac sarcoplasmic reticulum (SR). However, the structural…”
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In Cardiomyocytes, Binding of Unzipping Peptide Activates Ryanodine Receptor 2 and Reciprocally Inhibits Calmodulin Binding by Oda, Tetsuro, Yang, Yi, Nitu, Florentin R, Svensson, Bengt, Lu, Xiyuan, Fruen, Bradley R, Cornea, Razvan L, Bers, Donald M

“…RATIONALE:One hypothesis for elevated Ca leak through cardiac ryanodine receptors (ryanodine receptor 2 [RyR2]) in heart failure is interdomain unzipping that…”
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Localization of the Dantrolene-binding Sequence near the FK506-binding Protein-binding Site in the Three-dimensional Structure of the Ryanodine Receptor by Wang, Ruiwu, Zhong, Xiaowei, Meng, Xing, Koop, Andrea, Tian, Xixi, Jones, Peter P., Fruen, Bradley R., Wagenknecht, Terence, Liu, Zheng, Chen, S.R. Wayne

“…Dantrolene is believed to stabilize interdomain interactions between the NH2-terminal and central regions of ryanodine receptors by binding to the NH2-terminal…”
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Mapping the Ryanodine Receptor FK506-binding Protein Subunit Using Fluorescence Resonance Energy Transfer by Cornea, Razvan L., Nitu, Florentin R., Samsó, Montserrat, Thomas, David D., Fruen, Bradley R.

“…The 12-kDa FK506-binding proteins (FKBP12 and FKBP12.6) are regulatory subunits of ryanodine receptor (RyR) Ca2+ release channels. To investigate the…”
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FRET-based mapping of calmodulin bound to the RyR1 Ca²⁺ release channel by Cornea, Razvan L, Nitu, Florentin, Gruber, Simon, Kohler, Katherine, Satzer, Michael, Thomas, David D, Fruen, Bradley R

“…Calmodulin (CaM) functions as a regulatory subunit of ryanodine receptor (RyR) channels, modulating channel activity in response to changing [Ca²⁺]i. To…”
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Calmodulin Oxidation and Methionine to Glutamine Substitutions Reveal Methionine Residues Critical for Functional Interaction with Ryanodine Receptor-1 by Balog, Edward M., Norton, Laura E., Bloomquist, Rachel A., Cornea, Razvan L., Black, D.J., Louis, Charles F., Thomas, David D., Fruen, Bradley R.

“…Calmodulin (CaM) binds to the skeletal muscle ryanodine receptor Ca2+ release channel (RyR1) with high affinity, and it may act as a Ca2+-sensing subunit of…”
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Ablation of Skeletal Muscle Triadin Impairs FKBP12/RyR1 Channel Interactions Essential for Maintaining Resting Cytoplasmic Ca by Eltit, Jose M, Feng, Wei, Lopez, Jose R, Padilla, Isela T, Pessah, Isaac N, Molinski, Tadeusz F, Fruen, Bradley R, Allen, Paul D, Perez, Claudio F

“…Previously, we have shown that lack of expression of triadins in skeletal muscle cells results in significant increase of myoplasmic resting free Ca²⁺…”
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Ablation of Skeletal Muscle Triadin Impairs FKBP12/RyR1 Channel Interactions Essential for Maintaining Resting Cytoplasmic Ca2 by Eltit, Jose M., Feng, Wei, Lopez, Jose R., Padilla, Isela T., Pessah, Isaac N., Molinski, Tadeusz F., Fruen, Bradley R., Allen, Paul D., Perez, Claudio F.

“…Previously, we have shown that lack of expression of triadins in skeletal muscle cells results in significant increase of myoplasmic resting free Ca2+…”
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Dantrolene Inhibition of Sarcoplasmic Reticulum Ca2+Release by Direct and Specific Action at Skeletal Muscle Ryanodine Receptors by Fruen, Bradley R., Mickelson, James R., Louis, Charles F.

“…The skeletal muscle relaxant dantrolene inhibits the release of Ca2+ from the sarcoplasmic reticulum during excitation-contraction coupling and suppresses the…”
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Role of calmodulin methionine residues in mediating productive association with cardiac ryanodine receptors by Balog, Edward M, Norton, Laura E, Thomas, David D, Fruen, Bradley R

“…Calmodulin (CaM) binds to the cardiac ryanodine receptor Ca2+ release channel (RyR2) with high affinity and may act as a regulatory channel subunit. Here we…”
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Regulation of the RYR1 and RYR2 Ca2+ Release Channel Isoforms by Ca2+-Insensitive Mutants of Calmodulin by Fruen, Bradley R, Black, D. J, Bloomquist, Rachel A, Bardy, Jennifer M, Johnson, J. David, Louis, Charles F, Balog, Edward M

“…Calmodulin (CaM) may function as a regulatory subunit of ryanodine receptor (RYR) channels, modulating both channel activation and inhibition by Ca2+; however,…”
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Direct Detection of Calmodulin Tuning by Ryanodine Receptor Channel Targets Using a Ca2+-Sensitive Acrylodan-Labeled Calmodulin by Fruen, Bradley R, Balog, Edward M, Schafer, Janet, Nitu, Florentin R, Thomas, David D, Cornea, Razvan L

“…Calmodulin (CaM) activates the skeletal muscle ryanodine receptor (RyR1) at nanomolar Ca2+ concentrations but inhibits it at micromolar Ca2+ concentrations,…”
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Divergent effects of the malignant hyperthermia-susceptible Arg(615)-->Cys mutation on the Ca(2+) and Mg(2+) dependence of the RyR1 by Balog, E M, Fruen, B R, Shomer, N H, Louis, C F

“…The sarcoplasmic reticulum (SR) Ca(2+) release channel (RyR1) from malignant hyperthermia-susceptible (MHS) porcine skeletal muscle has a decreased sensitivity…”
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Calmodulin Dissociation Mediates Desensitization of the cADPR-Induced Ca2+ Release Mechanism by Thomas, Justyn M., Summerhill, Robin J., Fruen, Bradley R., Churchill, Grant C., Galione, Antony

“…Ryanodine receptor (RyR) activation by cyclic ADP-ribose (cADPR) is followed by homologous desensitization [1–3]. Though poorly understood, this “switching…”
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Dantrolene Inhibition of Ryanodine Receptor Ca2+Release Channels by Zhao, Fangyi, Li, Pin, Chen, S. R. Wayne, Louis, Charles F., Fruen, Bradley R.

“…As an inhibitor of Ca 2+ release through ryanodine receptor (RYR) channels, the skeletal muscle relaxant dantrolene has proven to be both a valuable…”
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FRET-based mapping of calmodulin bound to the RyR1 Ca 2+ release channel by Cornea, Razvan L., Nitu, Florentin, Gruber, Simon, Kohler, Katherine, Satzer, Michael, Thomas, David D., Fruen, Bradley R.

“…Calmodulin (CaM) functions as a regulatory subunit of ryanodine receptor (RyR) channels, modulating channel activity in response to changing [Ca 2+ ] i . To…”
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In Failing Cardiomyocytes, CaM-RyR2 Dissociation Leads to Defective Domain Interaction and Channel Destabilization by Oda, Tetsuro, Yang, Yi, Nitu, Florentin R., Fruen, Bradley R., Chen-Izu, Ye, Cornea, Razvan L., Bers, Donald M.

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FRET Detection of CaM-RyR2 Binding Modulation by S100A1 by Nitu, Florentin R., Fruen, Bradley R., Rohde, David, Most, Patrick, Bers, Donald M., Thomas, David D., Cornea, Razvan L.

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