Search Results - "Fruehwirth, Alexander"

Structure and Function Analysis of an Antibody Recognizing All Influenza A Subtypes by Kallewaard, Nicole L., Corti, Davide, Collins, Patrick J., Neu, Ursula, McAuliffe, Josephine M., Benjamin, Ebony, Wachter-Rosati, Leslie, Palmer-Hill, Frances J., Yuan, Andy Q., Walker, Philip A., Vorlaender, Matthias K., Bianchi, Siro, Guarino, Barbara, De Marco, Anna, Vanzetta, Fabrizia, Agatic, Gloria, Foglierini, Mathilde, Pinna, Debora, Fernandez-Rodriguez, Blanca, Fruehwirth, Alexander, Silacci, Chiara, Ogrodowicz, Roksana W., Martin, Stephen R., Sallusto, Federica, Suzich, JoAnn A., Lanzavecchia, Antonio, Zhu, Qing, Gamblin, Steven J., Skehel, John J.

“…Influenza virus remains a threat because of its ability to evade vaccine-induced immune responses due to antigenic drift. Here, we describe the isolation,…”
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The immune receptor Tim-3 acts as a trafficker in a Tim-3/galectin-9 autocrine loop in human myeloid leukemia cells by Gonçalves Silva, Isabel, Rüegg, Laura, Gibbs, Bernhard F., Bardelli, Marco, Fruehwirth, Alexander, Varani, Luca, Berger, Steffen M., Fasler-Kan, Elizaveta, Sumbayev, Vadim V.

“…The immune receptor Tim-3 is often highly expressed in human acute myeloid leukemia (AML) cells where it acts as a growth factor and inflammatory receptor…”
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Antibody-guided vaccine design: identification of protective epitopes by Lanzavecchia, Antonio, Frühwirth, Alexander, Perez, Laurent, Corti, Davide

“…Highlights • Protective antigens identified using nAbs from immune donors (analytic vaccinology). • Stabilized pre-fusion glycoproteins as effective vaccines…”
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Persistent Antibody Clonotypes Dominate the Serum Response to Influenza over Multiple Years and Repeated Vaccinations by Lee, Jiwon, Paparoditis, Philipp, Horton, Andrew P., Frühwirth, Alexander, McDaniel, Jonathan R., Jung, Jiwon, Boutz, Daniel R., Hussein, Dania A., Tanno, Yuri, Pappas, Leontios, Ippolito, Gregory C., Corti, Davide, Lanzavecchia, Antonio, Georgiou, George

“…Humans are repeatedly exposed to influenza virus via infections and vaccinations. Understanding how multiple exposures and pre-existing immunity impact…”
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Site‐specific serology unveils cross‐reactive monoclonal antibodies targeting influenza A hemagglutinin epitopes by Paparoditis, Philipp C. G., Fruehwirth, Alexander, Bevc, Kajetana, Low, Jun Siong, Jerak, Josipa, Terzaghi, Laura, Foglierini, Mathilde, Fernandez, Blanca, Jarrossay, David, Corti, Davide, Sallusto, Federica, Lanzavecchia, Antonio, Cassotta, Antonino

“…Efficient identification of human monoclonal antibodies targeting specific antigenic sites is pivotal for advancing vaccines and immunotherapies against…”
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Identification and Structure of a Multidonor Class of Head-Directed Influenza-Neutralizing Antibodies Reveal the Mechanism for Its Recurrent Elicitation by Cheung, Crystal Sao-Fong, Fruehwirth, Alexander, Paparoditis, Philipp Carl Georg, Shen, Chen-Hsiang, Foglierini, Mathilde, Joyce, M. Gordon, Leung, Kwanyee, Piccoli, Luca, Rawi, Reda, Silacci-Fregni, Chiara, Tsybovsky, Yaroslav, Verardi, Raffaello, Wang, Lingshu, Wang, Shuishu, Yang, Eun Sung, Zhang, Baoshan, Zhang, Yi, Chuang, Gwo-Yu, Corti, Davide, Mascola, John R., Shapiro, Lawrence, Kwong, Peter D., Lanzavecchia, Antonio, Zhou, Tongqing

“…Multidonor antibodies are of interest for vaccine design because they can in principle be elicited in the general population by a common set of immunogens. For…”
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