Search Results - "Frucht, Harold"

Pancreatic ductal adenocarcinoma: Risk factors, screening, and early detection by Becker, Andrew E, Hernandez, Yasmin G, Frucht, Harold, Lucas, Aimee L

“…Pancreatic cancer is the fourth most common cause of cancer-related deaths in the United States, with over 38000 deaths in 2013. The opportunity to detect…”
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Pancreatic Cancer Screening in a Prospective Cohort of High-Risk Patients: A Comprehensive Strategy of Imaging and Genetics by VERNA, Elizabeth C, HWANG, Caroline, FRUCHT, Harold, STEVENS, Peter D, ROTTERDAM, Heidrun, STAVROPOULOS, Stavros N, SY, Carolyn D, PRINCE, Martin A, CHUNG, Wendy K, FINE, Robert L, CHABOT, John A

“…Pancreatic cancer is a virtually uniformly fatal disease. We aimed to determine if screening to identify curable neoplasms is effective when offered to…”
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BRCA1 and BRCA2 germline mutations are frequently demonstrated in both high‐risk pancreatic cancer screening and pancreatic cancer cohorts by Lucas, Aimee L., Frado, Laura E., Hwang, Caroline, Kumar, Sheila, Khanna, Lauren G., Levinson, Elana J., Chabot, John A., Chung, Wendy K., Frucht, Harold

“…BACKGROUND Approximately 10% of pancreatic ductal adenocarcinoma (PDAC) is due to a genetic predisposition, including the breast and ovarian cancer syndrome…”
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Absence of pancreatic intraepithelial neoplasia predicts poor survival after resection of pancreatic cancer by Hassid, Benjamin G, Lucas, Aimee L, Salomao, Marcela, Weng, Chunhua, Liu, Feng, Khanna, Lauren G, Kumar, Sheila, Hwang, Caroline, Chabot, John A, Frucht, Harold

“…Pancreatic intraepithelial neoplasia (PanIN), thought to represent the dominant precursor of pancreatic adenocarcinoma (PDAC), is often found synchronously…”
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BRAF and KRAS gene mutations in intraductal papillary mucinous neoplasm/carcinoma (IPMN/IPMC) of the pancreas by Schönleben, Frank, Qiu, Wanglong, Bruckman, Karl C, Ciau, Nancy T, Li, Xiaojun, Lauerman, Margaret H, Frucht, Harold, Chabot, John A, Allendorf, John D, Remotti, Helen E, Su, Gloria H

“…Abstract The Raf/MEK/ERK (MAPK) signal transduction is an important mediator of a number of cellular fates including growth, proliferation, and survival. The…”
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Strengthening the Case for Stool DNA Tests as First-Line Colorectal Cancer Screening: Are We There Yet? by Lucas, Aimee L., MD, Hwang, Caroline, MD, Frucht, Harold, MD

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Costs and Cost Effectiveness of a Health Care Provider–Directed Intervention to Promote Colorectal Cancer Screening by SHANKARAN, Veena, THANH HA LUU, BENNETT, Charles L, SHEINFELD GORIN, Sherri, NONZEE, Narissa, RICHEY, Elizabeth, MCKOY, June M, GRAFF ZIVIN, Joshua, ASHFORD, Alfred, LANTIGUA, Rafael, FRUCHT, Harold, SCOPPETTONE, Marc

“…Colorectal cancer (CRC) screening remains underutilized in the United States. Prior studies reporting the cost effectiveness of randomized interventions to…”
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Human Colon Cancer Cell Proliferation Mediated by the M3 Muscarinic Cholinergic Receptor by FRUCHT, H, JENSEN, R. T, DEXTER, D, YANG, W.-L, YINGHUA XIAO

“…We have demonstrated previously cell surface receptors for gastrointestinal peptides on 10 human colon cancer cell lines. Because most of the cells studied…”
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Management of patients with increased risk for familial pancreatic cancer: updated recommendations from the International Cancer of the Pancreas Screening (CAPS) Consortium by Goggins, Michael, Overbeek, Kasper Alexander, Brand, Randall, Syngal, Sapna, Del Chiaro, Marco, Bartsch, Detlef K, Bassi, Claudio, Carrato, Alfredo, Farrell, James, Fishman, Elliot K, Fockens, Paul, Gress, Thomas M, van Hooft, Jeanin E, Hruban, R H, Kastrinos, Fay, Klein, Allison, Lennon, Anne Marie, Lucas, Aimee, Park, Walter, Rustgi, Anil, Simeone, Diane, Stoffel, Elena, Vasen, Hans F A, Cahen, Djuna L, Canto, Marcia Irene, Bruno, Marco

“…The International Cancer of the Pancreas Screening Consortium met in 2018 to update its consensus recommendations for the management of individuals with…”
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International Cancer of the Pancreas Screening (CAPS) Consortium summit on the management of patients with increased risk for familial pancreatic cancer by Canto, Marcia Irene, Harinck, Femme, Hruban, Ralph H, Offerhaus, George Johan, Poley, Jan-Werner, Kamel, Ihab, Nio, Yung, Schulick, Richard S, Bassi, Claudio, Kluijt, Irma, Levy, Michael J, Chak, Amitabh, Fockens, Paul, Goggins, Michael, Bruno, Marco

“…Screening individuals at increased risk for pancreatic cancer (PC) detects early, potentially curable, pancreatic neoplasia. To develop consortium statements…”
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498 Patient Refusal of Surgery for Pancreatic Adenocarcinoma May Contribute to Poor Survival: A Population Based Study by Amin, Sunil, Frucht, Harold

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Mice That Express Human Interleukin-8 Have Increased Mobilization of Immature Myeloid Cells, Which Exacerbates Inflammation and Accelerates Colon Carcinogenesis by Asfaha, Samuel, Dubeykovskiy, Alexander N, Tomita, Hiroyuki, Yang, Xiangdong, Stokes, Sarah, Shibata, Wataru, Friedman, Richard A, Ariyama, Hiroshi, Dubeykovskaya, Zinaida A, Muthupalani, Sureshkumar, Ericksen, Russell, Frucht, Harold, Fox, James G, Wang, Timothy C

“…Background & Aims Interleukin (IL)-8 has an important role in initiating inflammation in humans, attracting immune cells such as neutrophils through their…”
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Evidence for Treatment and Survival Disparities by Age in Pancreatic Adenocarcinoma: A Population Based Analysis by Amin, Sunil, Frucht, Harold

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Evidence for treatment and survival disparities by age in pancreatic adenocarcinoma: a population-based analysis by Amin, Sunil, Lucas, Aimee L, Frucht, Harold

“…Studies demonstrate safety and survival benefits of surgical resection in older individuals with pancreatic adenocarcinoma. We investigated treatment…”
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CDKN2A Germline Rare Coding Variants and Risk of Pancreatic Cancer in Minority Populations by McWilliams, Robert R, Wieben, Eric D, Chaffee, Kari G, Antwi, Samuel O, Raskin, Leon, Olopade, Olufunmilayo I, Li, Donghui, Highsmith, Jr, W Edward, Colon-Otero, Gerardo, Khanna, Lauren G, Permuth, Jennifer B, Olson, Janet E, Frucht, Harold, Genkinger, Jeanine, Zheng, Wei, Blot, William J, Wu, Lang, Almada, Luciana L, Fernandez-Zapico, Martin E, Sicotte, Hugues, Pedersen, Katrina S, Petersen, Gloria M

“…Pathogenic germline mutations in the tumor suppressor gene are rare and associated with highly penetrant familial melanoma and pancreatic cancer in…”
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High Prevalence of BRCA1 and BRCA2 Germline Mutations with Loss of Heterozygosity in a Series of Resected Pancreatic Adenocarcinoma and Other Neoplastic Lesions by LUCAS, Aimee L, SHAKYA, Reena, LUDWIG, Thomas, CHUNG, Wendy K, FRUCHT, Harold, LIPSYC, Marla D, MITCHEL, Elana B, KUMAR, Sheila, HWANG, Caroline, LIYONG DENG, DEVOE, Catherine, CHABOT, John A, SZABOLCS, Matthias

“…Pancreatic ductal adenocarcinoma (PDAC) is associated with the breast ovarian cancer syndrome (BRCA1/BRCA2) mutations. It is unknown if this association is…”
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The genetics of colorectal cancer by CALVERT, Paula M, FRUCHT, Harold

“…Colon cancer is a common disease that can be sporadic, familial, or inherited. Recent advances have contributed to the understanding of the molecular basis of…”
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Tu1243 Improved Survival Is Demonstrated Among Asian-Americans With Pancreatic Adenocarcinoma but May Not Be Explained by Increased Treatment by Amin, Sunil, Frucht, Harold, Lucas, Aimee L

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Risk of Perforation After Colonoscopy and Sigmoidoscopy: A Population-Based Study by Gatto, Nicolle M., Frucht, Harold, Sundararajan, Vijaya, Jacobson, Judith S., Grann, Victor R., Neugut, Alfred I.

“…Background: Although the risk of bowel perforation is often cited as a major factor in the choice between colonoscopy and sigmoidoscopy for colorectal…”
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Sa1146 Increased Survival Over Time of Individuals With Gastrinomas: A Population Based Analysis by Amin, Sunil, Kim, Michelle K, Lucas, Aimee L, Frucht, Harold

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