Search Results - "Frottin, Frédéric"

In Situ Structure of Neuronal C9orf72 Poly-GA Aggregates Reveals Proteasome Recruitment by Guo, Qiang, Lehmer, Carina, Martínez-Sánchez, Antonio, Rudack, Till, Beck, Florian, Hartmann, Hannelore, Pérez-Berlanga, Manuela, Frottin, Frédéric, Hipp, Mark S., Hartl, F. Ulrich, Edbauer, Dieter, Baumeister, Wolfgang, Fernández-Busnadiego, Rubén

“…Protein aggregation and dysfunction of the ubiquitin-proteasome system are hallmarks of many neurodegenerative diseases. Here, we address the elusive link…”
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Soluble Oligomers of PolyQ-Expanded Huntingtin Target a Multiplicity of Key Cellular Factors by Kim, Yujin E., Hosp, Fabian, Frottin, Frédéric, Ge, Hui, Mann, Matthias, Hayer-Hartl, Manajit, Hartl, F. Ulrich

“…Huntington’s disease is one of several neurodegenerative disorders characterized by the aggregation of polyglutamine (polyQ)-expanded mutant protein. How polyQ…”
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Multiple pathways of toxicity induced by C9orf72 dipeptide repeat aggregates and G4C2 RNA in a cellular model by Frottin, Frédéric, Pérez-Berlanga, Manuela, Hartl, F Ulrich, Hipp, Mark S

“…The most frequent genetic cause of amyotrophic lateral sclerosis and frontotemporal dementia is a G 4 C 2 repeat expansion in the C9orf72 gene. This expansion…”
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Cytoplasmic protein aggregates interfere with nucleocytoplasmic transport of protein and RNA by Woerner, Andreas C., Frottin, Frédéric, Hornburg, Daniel, Feng, Li R., Meissner, Felix, Patra, Maria, Tatzelt, Jörg, Mann, Matthias, Winklhofer, Konstanze F., Hartl, F. Ulrich, Hipp, Mark S.

“…Amyloid-like protein aggregation is associated with neurodegeneration and other pathologies. The nature of the toxic aggregate species and their mechanism of…”
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Gel‐like inclusions of C‐terminal fragments of TDP‐43 sequester stalled proteasomes in neurons by Riemenschneider, Henrick, Guo, Qiang, Bader, Jakob, Frottin, Frédéric, Farny, Daniel, Kleinberger, Gernot, Haass, Christian, Mann, Matthias, Hartl, F. Ulrich, Baumeister, Wolfgang, Hipp, Mark S, Meissner, Felix, Fernández‐Busnadiego, Rubén, Edbauer, Dieter

“…Aggregation of the multifunctional RNA‐binding protein TDP‐43 defines large subgroups of amyotrophic lateral sclerosis and frontotemporal dementia and…”
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Biochemical and structural analysis of N-myristoyltransferase mediated protein tagging by Monassa, Paul, Rivière, Frédéric, Dian, Cyril, Frottin, Frédéric, Giglione, Carmela, Meinnel, Thierry

“…N-terminal myristoylation is an essential eukaryotic modification crucial for cellular homeostasis in the context of many physiological processes…”
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The Proteomics of N-terminal Methionine Cleavage by Frottin, Frédéric, Martinez, Aude, Peynot, Philippe, Mitra, Sanghamitra, Holz, Richard C, Giglione, Carmela, Meinnel, Thierry

“…Methionine aminopeptidase (MAP) is a ubiquitous, essential enzyme involved in protein N-terminal methionine excision. According to the generally accepted…”
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Cell‐to‐cell transmission of C9orf72 poly‐(Gly‐Ala) triggers key features of ALS/FTD by Khosravi, Bahram, LaClair, Kathrine D, Riemenschneider, Henrick, Zhou, Qihui, Frottin, Frédéric, Mareljic, Nikola, Czuppa, Mareike, Farny, Daniel, Hartmann, Hannelore, Michaelsen, Meike, Arzberger, Thomas, Hartl, F Ulrich, Hipp, Mark S, Edbauer, Dieter

“…The C9orf72 repeat expansion causes amyotrophic lateral sclerosis and frontotemporal dementia, but the poor correlation between C9orf72 ‐specific pathology and…”
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Interplay Between N-Terminal Methionine Excision and FtsH Protease Is Essential for Normal Chloroplast Development and Function in Arabidopsis by Adam, Zach, Frottin, Frédéric, Espagne, Christelle, Meinnel, Thierry, Giglione, Carmela

“…N-terminal methionine excision (NME) is the earliest modification affecting most proteins. All compartments in which protein synthesis occurs contain dedicated…”
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MetAP1 and MetAP2 drive cell selectivity for a potent anti-cancer agent in synergy, by controlling glutathione redox state by Frottin, Frédéric, Bienvenut, Willy V, Bignon, Jérôme, Jacquet, Eric, Vaca Jacome, Alvaro Sebastian, Van Dorsselaer, Alain, Cianferani, Sarah, Carapito, Christine, Meinnel, Thierry, Giglione, Carmela

“…Fumagillin and its derivatives are therapeutically useful because they can decrease cancer progression. The specific molecular target of fumagillin is…”
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Cotranslational Proteolysis Dominates Glutathione Homeostasis to Support Proper Growth and Development by Frottin, Frédéric, Espagne, Christelle, Traverso, José A, Mauve, Caroline, Valot, Benoît, Lelarge-Trouverie, Caroline, Zivy, Michel, Noctor, Graham, Meinnel, Thierry, Giglione, Carmela

“…The earliest proteolytic event affecting most proteins is the excision of the initiating Met (NME). This is an essential and ubiquitous cotranslational process…”
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Advances in nuclear proteostasis of metazoans by Buggiani, Julia, Meinnel, Thierry, Giglione, Carmela, Frottin, Frédéric

“…The proteostasis network and associated protein quality control (PQC) mechanisms ensure proteome functionality and are essential for cell survival. A…”
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Author Correction: Gel-like inclusions of C-terminal fragments of TDP-43 sequester stalled proteasomes in neurons by Riemenschneider, Henrick, Guo, Qiang, Bader, Jakob, Frottin, Frédéric, Farny, Daniel, Kleinberger, Gernot, Haass, Christian, Mann, Matthias, Hartl, F Ulrich, Baumeister, Wolfgang, Hipp, Mark S, Meissner, Felix, Fernández-Busnadiego, Rubén, Edbauer, Dieter

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Multiple pathways of toxicity induced by C9orf72 dipeptide repeat aggregates and G.sub.4C.sub.2 RNA in a cellular model by Frottin, Frédéric, Pérez-Berlanga, Manuela, Hartl, F Ulrich, Hipp, Mark S

“…The most frequent genetic cause of amyotrophic lateral sclerosis and frontotemporal dementia is a G.sub.4C.sub.2 repeat expansion in the C9orf72 gene. This…”
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The Proteomics of N-terminal Methionine CleavageS by Frottin, Frédéric, Martinez, Aude, Peynot, Philippe, Mitra, Sanghamitra, Holz, Richard C., Giglione, Carmela, Meinnel, Thierry

“…Methionine aminopeptidase (MAP) is a ubiquitous, essential enzyme involved in protein N-terminal methionine excision. According to the generally accepted…”
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