Search Results - "Frostner, Eleonor Åsander"

Cell-permeable succinate prodrugs bypass mitochondrial complex I deficiency by Ehinger, Johannes K., Piel, Sarah, Ford, Rhonan, Karlsson, Michael, Sjövall, Fredrik, Frostner, Eleonor Åsander, Morota, Saori, Taylor, Robert W., Turnbull, Doug M., Cornell, Clive, Moss, Steven J., Metzsch, Carsten, Hansson, Magnus J., Fliri, Hans, Elmér, Eskil

“…Mitochondrial complex I (CI) deficiency is the most prevalent defect in the respiratory chain in paediatric mitochondrial disease. This heterogeneous group of…”
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Cell-Permeable Succinate Rescues Mitochondrial Respiration in Cellular Models of Amiodarone Toxicity by Bețiu, Alina M, Chamkha, Imen, Gustafsson, Ellen, Meijer, Elna, Avram, Vlad F, Åsander Frostner, Eleonor, Ehinger, Johannes K, Petrescu, Lucian, Muntean, Danina M, Elmér, Eskil

“…Amiodarone is a potent antiarrhythmic drug and displays substantial liver toxicity in humans. It has previously been demonstrated that amiodarone and its…”
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Cytokine and nitric oxide levels in patients with sepsis--temporal evolvement and relation to platelet mitochondrial respiratory function by Sjövall, Fredrik, Morota, Saori, Asander Frostner, Eleonor, Hansson, Magnus J, Elmér, Eskil

“…The levels of nitric oxide (NO) and various cytokines are known to be increased during sepsis. These signaling molecules could potentially act as regulators…”
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Cell-Permeable Succinate Rescues Mitochondrial Respiration in Cellular Models of Statin Toxicity by Avram, Vlad F, Chamkha, Imen, Åsander-Frostner, Eleonor, Ehinger, Johannes K, Timar, Romulus Z, Hansson, Magnus J, Muntean, Danina M, Elmér, Eskil

“…Statins are the cornerstone of lipid-lowering therapy. Although generally well tolerated, statin-associated muscle symptoms (SAMS) represent the main reason…”
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Cellular alterations identified in pluripotent stem cell-derived midbrain spheroids generated from a female patient with progressive external ophthalmoplegia and parkinsonism who carries a novel variation (p.Q811R) in the POLG1 gene by Chumarina, Margarita, Russ, Kaspar, Azevedo, Carla, Heuer, Andreas, Pihl, Maria, Collin, Anna, Frostner, Eleonor Åsander, Elmer, Eskil, Hyttel, Poul, Cappelletti, Graziella, Zini, Michela, Goldwurm, Stefano, Roybon, Laurent

“…Variations in the POLG1 gene encoding the catalytic subunit of the mitochondrial DNA polymerase gamma, have recently been associated with Parkinson's disease…”
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Bioenergetic bypass using cell-permeable succinate, but not methylene blue, attenuates metformin-induced lactate production by Piel, Sarah, Ehinger, Johannes K., Chamkha, Imen, Frostner, Eleonor Åsander, Sjövall, Fredrik, Elmér, Eskil, Hansson, Magnus J.

“…Background Metformin is the most common pharmacological treatment for type 2 diabetes. It is considered safe but has been associated with the development of…”
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Urban PM2.5 Induces Cellular Toxicity, Hormone Dysregulation, Oxidative Damage, Inflammation, and Mitochondrial Interference in the HRT8 Trophoblast Cell Line by Nääv, Åsa, Erlandsson, Lena, Isaxon, Christina, Åsander Frostner, Eleonor, Ehinger, Johannes, Sporre, Moa K, Krais, Annette M, Strandberg, Bo, Lundh, Thomas, Elmér, Eskil, Malmqvist, Ebba, Hansson, Stefan R

“…Epidemiological studies have found air pollution to be a driver of adverse pregnancy outcomes, including gestational diabetes, low term birth weight and…”
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Mitochondrial function in peripheral blood cells across the human lifespan by Ehinger, Johannes K., Westerlund, Emil, Frostner, Eleonor Åsander, Karlsson, Michael, Paul, Gesine, Sjövall, Fredrik, Elmér, Eskil

“…Mitochondrial dysfunction is considered a hallmark of aging. Up to now, a gradual decline of mitochondrial respiration with advancing age has mainly been…”
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Oxygen consumption in platelets as an adjunct diagnostic method for pediatric mitochondrial disease by Westerlund, Emil, Marelsson, Sigurður E, Ehinger, Johannes K, Sjövall, Fredrik, Morota, Saori, Åsander Frostner, Eleonor, Oldfors, Anders, Darin, Niklas, Lundgren, Johan, Hansson, Magnus J, Fellman, Vineta, Elmér, Eskil

“…Background Diagnosing mitochondrial disease (MD) is a challenge. In addition to genetic analyses, clinical practice is to perform invasive procedures such as…”
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Mitochondrial respiration in human viable platelets--methodology and influence of gender, age and storage by Sjövall, Fredrik, Ehinger, Johannes K H, Marelsson, Sigurður E, Morota, Saori, Frostner, Eleonor Asander, Uchino, Hiroyuki, Lundgren, Johan, Arnbjörnsson, Einar, Hansson, Magnus J, Fellman, Vineta, Elmér, Eskil

“…Studying whole cell preparations with intact mitochondria and respiratory complexes has a clear benefit compared to isolated or disrupted mitochondria due to…”
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Cytokine and nitric oxide levels in patients with sepsis--temporal evolvement and relation to platelet mitochondrial respiratory function by Sjövall, Fredrik, Morota, Saori, Frostner, Eleonor Åsander, Hansson, Magnus J, Elmér, Eskil

“…The levels of nitric oxide (NO) and various cytokines are known to be increased during sepsis. These signaling molecules could potentially act as regulators…”
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Correlation of mitochondrial respiration in platelets, peripheral blood mononuclear cells and muscle fibers by Westerlund, Emil, Marelsson, Sigurður E., Karlsson, Michael, Sjövall, Fredrik, Chamkha, Imen, Åsander Frostner, Eleonor, Lundgren, Johan, Fellman, Vineta, Eklund, Erik A., Steding-Ehrenborg, Katarina, Darin, Niklas, Paul, Gesine, Hansson, Magnus J., Ehinger, Johannes K., Elmér, Eskil

“…There is a growing interest for the possibility of using peripheral blood cells (including platelets) as markers for mitochondrial function in less accessible…”
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Ovarian cancer cells stimulate uPA gene expression in fibroblastic stromal cells via multiple paracrine and autocrine mechanisms by Noskova, Vera, Ahmadi, Sara, Åsander, Eleonor, Casslén, Bertil

“…Abstract Objectives Expression of uPA mRNA is massively up-regulated in the stroma of poorly differentiated ovarian tumors. We hypothesized that this…”
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