Search Results - "Frost, William N"

Modular Deconstruction Reveals the Dynamical and Physical Building Blocks of a Locomotion Motor Program by Bruno, Angela M., Frost, William N., Humphries, Mark D.

“…The neural substrates of motor programs are only well understood for small, dedicated circuits. Here we investigate how a motor program is constructed within a…”
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Memory Formation in Tritonia via Recruitment of Variably Committed Neurons by Hill, Evan S., Vasireddi, Sunil K., Wang, Jean, Bruno, Angela M., Frost, William N.

“…Prior studies have found that functional networks can rapidly add neurons as they build short-term memories, yet little is known about the principles…”
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A spiral attractor network drives rhythmic locomotion by Bruno, Angela M, Frost, William N, Humphries, Mark D

“…The joint activity of neural populations is high dimensional and complex. One strategy for reaching a tractable understanding of circuit function is to seek…”
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Reduced presynaptic vesicle stores mediate cellular and network plasticity defects in an early-stage mouse model of Alzheimer's disease by Chakroborty, Shreaya, Hill, Evan S, Christian, Daniel T, Helfrich, Rosalind, Riley, Shannon, Schneider, Corinne, Kapecki, Nicolas, Mustaly-Kalimi, Sarah, Seiler, Figen A, Peterson, Daniel A, West, Anthony R, Vertel, Barbara M, Frost, William N, Stutzmann, Grace E

“…Identifying effective strategies to prevent memory loss in AD has eluded researchers to date, and likely reflects insufficient understanding of early…”
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Neuroethology: Generating complex behavioral sequences with distributed nerve nets by Frost, William N.

“…How are animals equipped with only diffusely distributed nerve nets able to generate complex behaviors? A new study in Hydra vulgaris proposes that a…”
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An Argument for Amphetamine-Induced Hallucinations in an Invertebrate by Lee, Anne H, Brandon, Cindy L, Wang, Jean, Frost, William N

“…Hallucinations - compelling perceptions of stimuli that aren't really there - occur in many psychiatric and neurological disorders, and are triggered by…”
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Variable neuronal participation in stereotypic motor programs by Hill, Evan S, Vasireddi, Sunil K, Bruno, Angela M, Wang, Jean, Frost, William N

“…To what extent are motor networks underlying rhythmic behaviors rigidly hard-wired versus fluid and dynamic entities? Do the members of motor networks change…”
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Axonal conduction block as a novel mechanism of prepulse inhibition by Lee, Anne H, Megalou, Evgenia V, Wang, Jean, Frost, William N

“…In prepulse inhibition (PPI), the startle response to a strong, unexpected stimulus is diminished if shortly preceded by the onset of a different stimulus…”
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Watching a memory form-VSD imaging reveals a novel memory mechanism by Hill, Evan S., Vasireddi, Sunil K., Wang, Jean, Bruno, Angela M., Frost, William N.

“…Studies of the mechanisms underlying memory formation have largely focused on the synapse. However, recent evidence suggests that additional, non-synaptic,…”
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Surprising multifunctionality of a Tritonia swim CPG neuron: C2 drives the early phase of postswim crawling despite being silent during the behavior by Hill, Evan S, Wang, Jean, Brown, Jeffrey W, Mistry, Viral K, Frost, William N

“…In response to a suitably aversive skin stimulus, the marine mollusk launches an escape swim followed by several minutes of high-speed crawling. The two escape…”
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Division of labor for defensive retaliation and preemption by the peripheral and central nervous systems in the nudibranch Berghia by Brown, Jeffrey W, Berg, Ondine H, Boutko, Anastasiya, Stoerck, Cody, Boersma, Margaret A, Frost, William N

“…Relatively little is known about how peripheral nervous systems (PNSs) contribute to the patterning of behavior in which their role transcends the simple…”
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Photodiode-Based Optical Imaging for Recording Network Dynamics with Single-Neuron Resolution in Non-Transgenic Invertebrates by Hill, Evan S, Brown, Jeffrey W, Frost, William N

“…The development of transgenic invertebrate preparations in which the activity of specifiable sets of neurons can be recorded and manipulated with light…”
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Serial-section atlas of the Tritonia pedal ganglion by Brandon, Christopher, Britton, Matthew, Fan, David, Ferrier, Andrew R, Hill, Evan S, Perez, Adrian, Wang, Jean, Wang, Nengding, Frost, William N

“…The pedal ganglion of the nudibranch gastropod Tritonia diomedea has been the focus of neurophysiological studies for more than 50 yr. These investigations…”
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Recent Developments in VSD Imaging of Small Neuronal Networks by Hill, Evan S, Bruno, Angela M, Frost, William N

“…Voltage-sensitive dye (VSD) imaging is a powerful technique that can provide, in single experiments, a large-scale view of network activity unobtainable with…”
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Dynamic neuromodulation of synaptic strength intrinsic to a central pattern generator circuit by Katz, Paul S, Getting, Peter A, Frost, William N

“…Motor circuits are often thought to be physically separate from their neuromodulatory systems. We report here a counter example, where neurons within a circuit…”
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Validation of independent component analysis for rapid spike sorting of optical recording data by Hill, Evan S, Moore-Kochlacs, Caroline, Vasireddi, Sunil K, Sejnowski, Terrence J, Frost, William N

“…Independent component analysis (ICA) is a technique that can be used to extract the source signals from sets of signal mixtures where the sources themselves…”
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Highly Dissimilar Behaviors Mediated by a Multifunctional Network in the Marine Mollusk Tritonia diomedea by Popescu, Ion R, Frost, William N

“…Several motor networks have now been found to be multifunctional, in which one group of neurons participates in the generation of multiple behavioral motor…”
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Parameter Space Analysis Suggests Multi-Site Plasticity Contributes to Motor Pattern Initiation in Tritonia by Calin-Jageman, Robert J, Tunstall, Mark J, Mensh, Brett D, Katz, Paul S, Frost, William N

“…1 Department of Biology, Georgia State University, Atlanta, Georgia; 2 Department of Neuroscience, Columbia University College of Physicians and Surgeons, New…”
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A stereo-compound hybrid microscope for combined intracellular and optical recording of invertebrate neural network activity by Frost, William N., Wang, Jean, Brandon, Christopher J.

“…Optical recording studies of invertebrate neural networks with voltage-sensitive dyes seldom employ conventional intracellular electrodes. This may in part be…”
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A Cellular Mechanism for Prepulse Inhibition by Frost, William N, Tian, Li-Ming, Hoppe, Travis A, Mongeluzi, Donna L, Wang, Jean

“…In prepulse inhibition (PPI), startle responses to sudden, unexpected stimuli are markedly attenuated if immediately preceded by a weak stimulus of almost any…”
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