Search Results - "Frost, Carminita"

CBD activation of TRPV1 induces oxidative signaling and subsequent ER stress in breast cancer cell lines by Harpe, Amy, Beukes, Natasha, Frost, Carminita L.

“…Endoplasmic reticulum (ER) stress is an imbalance between the protein‐folding load and capacity of ER. It can be induced by various physiological conditions,…”
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Cannabinoid Combination Induces Cytoplasmic Vacuolation in MCF-7 Breast Cancer Cells by Schoeman, Recardia, Beukes, Natasha, Frost, Carminita

“…This study evaluated the synergistic anti-cancer potential of cannabinoid combinations across the MDA-MB-231 and MCF-7 human breast cancer cell lines…”
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Effect of oral cannabis administration on the fat depots of obese and streptozotocin‐induced diabetic rats by Ramlugon, Sonaal, Levendal, Ruby‐Ann, Frost, Carminita L.

“…The prevalence of obesity and insulin‐resistance is on the rise, globally. Cannabis have been shown to have anti‐diabetic/obesity properties, however, the…”
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Biospeciation of Oxidovanadium(IV) Imidazolyl-Carboxylate Complexes and Their Action on Glucose-Stimulated Insulin Secretion in Pancreatic Cells by Ugirinema, Vital, Odei-Addo, Frank, Frost, Carminita L, Tshentu, Zenixole R

“…The reaction of the vanadyl ion (VO ) with imidazole-4-carboxylic acid (Im4COOH), imidazole-2-carboxylic acid (Im2COOH) and methylimidazole-2-carboxylic acid…”
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The effects of Cannabis sativa and cannabinoids on the inhibition of pancreatic lipase – An enzyme involved in obesity by Frans, Phelokazi, Mkabayi, Lithalethu, Pletschke, Brett I., Frost, Carminita L.

“…Obesity is a chronic noncommunicable disease characterized by excessive body fat that can have negative health consequences. Obesity is a complex disease…”
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Tulbaghia violacea (Harv) Exerts its Antifungal Activity by Reducing Ergosterol Production in Aspergillus flavus by Somai, Benesh M., Belewa, Vuyokazi, Frost, Carminita

“…Opportunistic infections in immunosuppressed patients have led to an increase in fungal infections, with Aspergillus being one of the main causative agents…”
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Real-time monitoring of 3T3-L1 preadipocyte differentiation using a commercially available electric cell-substrate impedance sensor system by Kramer, Adam H., Joos-Vandewalle, Julia, Edkins, Adrienne L., Frost, Carminita L., Prinsloo, Earl

“…[Display omitted] •Real-time in vitro monitoring assay of adipogenesis in murine 3T3-L1 cell model.•Impedance based label free cell monitoring.•Detection of…”
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Synthesis, characterization, crystal structures, and anticancer activity of some new 2,3-dihydro-1,5-benzoxazepines by Odame, Felix, Schoeman, Recardia, Krause, Jason, Hosten, Eric C., Tshentu, Zenixole R., Frost, Carminita

“…Various benzoxazepine derivatives have been synthesized and characterized using IR, NMR, GC–MS, and microanalysis. The single-crystal X-ray structures of 2…”
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Inhibitory effects of selected cannabinoids against dipeptidyl peptidase IV, an enzyme linked to type 2 diabetes by Mkabayi, Lithalethu, Viljoen, Zenobia, Krause, Rui W.M., Lobb, Kevin A., Pletschke, Brett I., Frost, Carminita L.

“…In recent times the decriminalisation of cannabis globally has increased its use as an alternative medication. Where it has been used in modern medicinal…”
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Selected terpenoids from medicinal plants modulate endoplasmic reticulum stress in metabolic disorders by Beukes, Natasha, Levendal, Ruby-Ann, Frost, Carminita L.

“…Objectives The majority of research performed on cellular stress and apoptosis focuses on mitochondrial dysfunction; however, the importance of the endoplasmic…”
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Cannabis with breast cancer treatment: propitious or pernicious? by Schoeman, Recardia, de la Harpe, Amy, Beukes, Natasha, Frost, Carminita L.

“…Cannabis has been used for various medicinal applications including, but not limited to, cancer: most commonly to treat chemotherapy-associated side effects…”
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The cardioprotective effects of marrubiin, a diterpenoid found in Leonotis leonurus extracts by Mnonopi, Nandipha, Levendal, Ruby-Ann, Davies-Coleman, Michael T., Frost, Carminita L.

“…Leonotis leonurus L. (Lamiaceae) is used as a traditional medicine for a variety of ailments in South Africa. The diterpene marrubiin is the major product…”
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Electrospun nylon 6 nanofibers incorporated with 2-substituted N-alkylimidazoles and their silver(I) complexes for antibacterial applications by Kleyi, Phumelele, Frost, Carminita L., Tshentu, Zenixole R., Torto, Nelson

“…ABSTRACT The article presents the incorporation of biocides [2‐substituted N‐alkylimidazoles and their silver(I) complexes] into electrospun nylon 6 nanofibers…”
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In Vitro Screening of Synthetic Fluorogenic Substrates for Detection of Cancer Procoagulant Activity by Krause, Jason, Frost, Carminita L.

“…Cancer procoagulant (CP), a direct activator of coagulation factor X, is among one of the tumour cell products or activities which may promote fibrin formation…”
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Synthesis, characterization, computational studies and DPPH scavenging activity of some triazatetracyclic derivatives by Odame, F., Hosten, Eric C., Betz, R., Krause, J., Frost, Carminita L., Lobb, K., Tshentu, Zenixole R.

“…Some dihydrobenzo[4,5]imidazo[1,2-c]quinazolines have been synthesized from aldehydes and ketones, using the ketones as both reagents and solvents and…”
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pH-metric chemical speciation modeling and studies of in vitro antidiabetic effects of bis[(imidazolyl)carboxylato]oxidovanadium(IV) complexes by Gundhla, Isaac Z., Walmsley, Ryan S., Ugirinema, Vital, Mnonopi, Nandipha O., Hosten, Eric, Betz, Richard, Frost, Carminita L., Tshentu, Zenixole R.

“…A range of bidentate N,O-donor ligands of the imidazolyl-carboxylate moiety, which partially mimic naturally occurring bioligands, were prepared and reacted…”
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Improving the understanding of plasma kallikrein contribution to arterial thrombus formation using two plant protease inhibitors by Salu, Bruno R, Pando, Silvana Cristina, Brito, Marlon V De, Medina, André Fernando, Odei-Addo, Frank, Frost, Carminita, Naude, Ryno, Sampaio, Misako U, Emsley, Jonas, Maffei, Francisco Humberto A., Oliva, Maria Luiza V

“…The purpose of antithrombotic therapy is the prevention of thrombus formation and/or its extension with a minimum risk of bleeding. The inhibition of a variety…”
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Synthesis, Characterization and Biological Activity of Some Dithiourea Derivatives by Odame, Felix, Hosten, Eric, Krause, Jason, Isaacs, Michelle, Hoppe, Heinrich, Khanye, Setshaba D, Sayed, Yasien, Frost, Carminita, Lobb, Kevin, Tshentu, Zenixole

“…Novel dithiourea derivatives have been designed as HIV-1 protease inhibitors using Autodock 4.2, synthesized and characterized by spectroscopic methods and…”
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Synthesis, characterization and DPPH scavenging activity of some benzimidazole derivatives by Odame, F., Krause, J., C. Hosten, E., Betz, R., Lobb, K., R. Tshentu, Z., L. Frost, C.

“…A base-catalyzed conversion of aldehydes to benzimidazoles has been achieved. The compounds have been characterized by IR, NMR, micoranalysis, and GC-MS. The…”
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Fabrication and Antibacterial Activity of Electrospun Nylon 6 Nanofibers Grafted With 2-Substituted Vinylimidazoles by Kleyi, Phumelele, Jacobs, Valencia, Na, Choon-Ki, Frost, Carminita L., Tshentu, Zenixole R., Torto, Nelson

“…The authors present the fabrication of electrospun nanofibers with antimicrobial properties by the UV-initiated grafting (photo-grafting) of 2-substituted…”
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