In vitro effects of Blepharocalyx salicifolius (H.B.K.) O. Berg on the viability of Echinococcus ortleppi protoscoleces

In vitro effects of Blepharocalyx salicifolius (H.B.K.) O. Berg on the viability of Echinococcus ortleppi protoscoleces

Scolicidal agents are important in the treatment of cystic echinococcosis. This study evaluated the scolicidal activity of the plant Blepharocalyx salicifolius (H.B.K.) Berg against Echinococcus ortleppi protoscoleces. The parasite species was identified by amplifying a fragment of the gene cytochro...

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Published in:Revista do Instituto de Medicina Tropical de São Paulo Vol. 59; pp. e42 - 5
Main Authors: Noal, Charlise Bolson, Monteiro, Danieli Urach, Brum, Thiele Faccim de, Emmanouilidis, Jessica, Zanette, Regis Adriel, Morel, Ademir Farias, Stefanon, Eliza Beti de Cassia, Frosi, Marina, la Rue, Mario Luiz de
Format: Journal Article
Language:English
Published: Brazil Instituto de Medicina Tropical de Sao Paulo 01-01-2017
Instituto de Medicina Tropical
Universidade de São Paulo (USP)
Subjects:
Animals
Anthelmintics - pharmacology
Brief Communication
Dose-Response Relationship, Drug
Echinococcus - drug effects
Echinococcus ortleppi
Gallic acid
Myrtaceae - chemistry
Parasitic Sensitivity Tests
Plant Extracts - pharmacology
Protoscolicidal
Scolicidal agent
TROPICAL MEDICINE
Protoscolicidal
Gallic acid
Scolicidal agent
Echinococcus ortleppi
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Summary:Scolicidal agents are important in the treatment of cystic echinococcosis. This study evaluated the scolicidal activity of the plant Blepharocalyx salicifolius (H.B.K.) Berg against Echinococcus ortleppi protoscoleces. The parasite species was identified by amplifying a fragment of the gene cytochrome c oxidase subunit 1 (COX 1). B. salicifolius crude extract at concentrations of 100, 200, 300 and 400 mg/mL was analyzed at different times (5, 10, 15, 30, 45 and 60 min). N-butanol and ethyl acetate fractions (100 and 200 mg/ mL) were also analyzed at 5, 10, 15 and 30 min. Both fractions showed 100% scolicidal activity at the concentration of 200 mg/mL at 5 min. Gallic acid, identified as the major compound of the ethyl acetate fraction- was responsible for the observed scolicidal activity. The results showed that crude extract and fractions of B. salicifolius have scolicidal effect against E. ortleppi protoscoleces.
ISSN:0036-4665
1678-9946
1678-9946
0036-4665
DOI:10.1590/S1678-9946201759042