Search Results - "Frontiers in oncology"

Role of Matrix Metalloproteinases in Angiogenesis and Cancer by Quintero-Fabián, Saray, Arreola, Rodrigo, Becerril-Villanueva, Enrique, Torres-Romero, Julio César, Arana-Argáez, Victor, Lara-Riegos, Julio, Ramírez-Camacho, Mario Alberto, Alvarez-Sánchez, María Elizbeth

“…During angiogenesis, new vessels emerge from existing endothelial lined vessels to promote the degradation of the vascular basement membrane and remodel the…”
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Lactate in the Regulation of Tumor Microenvironment and Therapeutic Approaches by de la Cruz-López, Karen G., Castro-Muñoz, Leonardo Josué, Reyes-Hernández, Diego O., García-Carrancá, Alejandro, Manzo-Merino, Joaquín

“…Tumor cells must generate sufficient ATP and biosynthetic precursors in order to maintain cell proliferation requirements. Otto Warburg showed that tumor cells…”
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PI3K/Akt/mTOR Pathway and Its Role in Cancer Therapeutics: Are We Making Headway? by Peng, Yan, Wang, Yuanyuan, Zhou, Cheng, Mei, Wuxuan, Zeng, Changchun

“…Cancer is a severe public health issue that is a leading cause of mortality globally. It is also an impediment to improving life expectancy worldwide…”
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The role of BCL-2 family proteins in regulating apoptosis and cancer therapy by Qian, Shanna, Wei, Zhong, Yang, Wanting, Huang, Jinling, Yang, Yinfeng, Wang, Jinghui

“…Apoptosis, as a very important biological process, is a response to developmental cues or cellular stress. Impaired apoptosis plays a central role in the…”
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Tumor-Associated Macrophages: Recent Insights and Therapies by Zhou, Jiawei, Tang, Ziwei, Gao, Siyang, Li, Chunyu, Feng, Yiting, Zhou, Xikun

“…Macrophages, which have functions of engulfing and digesting foreign substances, can clear away harmful matter, including cellular debris and tumor cells…”
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Anti-PD-1 and Anti-CTLA-4 Therapies in Cancer: Mechanisms of Action, Efficacy, and Limitations by Seidel, Judith A, Otsuka, Atsushi, Kabashima, Kenji

“…Melanoma, a skin cancer associated with high mortality rates, is highly radio- and chemotherapy resistant but can also be very immunogenic. These circumstances…”
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Evaluating the Polarization of Tumor-Associated Macrophages Into M1 and M2 Phenotypes in Human Cancer Tissue: Technicalities and Challenges in Routine Clinical Practice by Jayasingam, Sharmilla Devi, Citartan, Marimuthu, Thang, Thean Hock, Mat Zin, Anani Aila, Ang, Kai Cheen, Ch'ng, Ewe Seng

“…Tumor-associated macrophages (TAMs) as immune cells within the tumor microenvironment have gained much interests as basic science regarding their roles in…”
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Tumor Associated Neutrophils. Their Role in Tumorigenesis, Metastasis, Prognosis and Therapy by Masucci, Maria Teresa, Minopoli, Michele, Carriero, Maria Vincenza

“…Tumor Associated Neutrophils (TANs) are engaged into the tumor microenvironment by cytokines and chemokines, can be distinguished according to their activation…”
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Multidrug Resistance in Cancer: Understanding Molecular Mechanisms, Immunoprevention and Therapeutic Approaches by Emran, Talha Bin, Shahriar, Asif, Mahmud, Aar Rafi, Rahman, Tanjilur, Abir, Mehedy Hasan, Siddiquee, Mohd. Faijanur - Rob, Ahmed, Hossain, Rahman, Nova, Nainu, Firzan, Wahyudin, Elly, Mitra, Saikat, Dhama, Kuldeep, Habiballah, Mahmoud M., Haque, Shafiul, Islam, Ariful, Hassan, Mohammad Mahmudul

“…Cancer is one of the leading causes of death worldwide. Several treatments are available for cancer treatment, but many treatment methods are ineffective…”
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Pyruvate Kinase M2 and Cancer: The Role of PKM2 in Promoting Tumorigenesis by Zahra, Kulsoom, Dey, Tulika, Ashish, Mishra, Surendra Pratap, Pandey, Uma

“…Pyruvate kinase plays a pivotal role in regulating cell metabolism. The final and rate-limiting step of glycolysis is the conversion of Phosphoenolpyruvate…”
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Ultra-High Dose Rate (FLASH) Radiotherapy: Silver Bullet or Fool's Gold? by Wilson, Joseph D, Hammond, Ester M, Higgins, Geoff S, Petersson, Kristoffer

“…Radiotherapy is a cornerstone of both curative and palliative cancer care. However, radiotherapy is severely limited by radiation-induced toxicities. If these…”
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Combination Therapy With Histone Deacetylase Inhibitors (HDACi) for the Treatment of Cancer: Achieving the Full Therapeutic Potential of HDACi by Suraweera, Amila, O'Byrne, Kenneth J, Richard, Derek J

“…Genetic and epigenetic changes in DNA are involved in cancer development and tumor progression. Histone deacetylases (HDACs) are key regulators of gene…”
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Chemical and Pharmacological Aspects of Caffeic Acid and Its Activity in Hepatocarcinoma by Espíndola, Kaio Murilo Monteiro, Ferreira, Roseane Guimarães, Narvaez, Luis Eduardo Mosquera, Silva Rosario, Amanda Caroline Rocha, da Silva, Agnes Hanna Machado, Silva, Ana Gabrielle Bispo, Vieira, Ana Paula Oliveira, Monteiro, Marta Chagas

“…Caffeic acid (CA) is a phenolic compound synthesized by all plant species and is present in foods such as coffee, wine, tea, and popular medicines such as…”
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CRISPR Gene Therapy: Applications, Limitations, and Implications for the Future by Uddin, Fathema, Rudin, Charles M, Sen, Triparna

“…A series of recent discoveries harnessing the adaptive immune system of prokaryotes to perform targeted genome editing is having a transformative influence…”
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Tumor-Associated Macrophages in Human Breast, Colorectal, Lung, Ovarian and Prostate Cancers by Larionova, Irina, Tuguzbaeva, Gulnara, Ponomaryova, Anastasia, Stakheyeva, Marina, Cherdyntseva, Nadezhda, Pavlov, Valentin, Choinzonov, Evgeniy, Kzhyshkowska, Julia

“…Tumor-associated macrophages (TAMs) are major innate immune cells that constitute up to 50% of the cell mass of human tumors. TAMs are highly heterogeneous…”
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EMT Factors and Metabolic Pathways in Cancer by Georgakopoulos-Soares, Ilias, Chartoumpekis, Dionysios V, Kyriazopoulou, Venetsana, Zaravinos, Apostolos

“…The epithelial-mesenchymal transition (EMT) represents a biological program during which epithelial cells lose their cell identity and acquire a mesenchymal…”
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The Global Landscape of EBV-Associated Tumors by Shannon-Lowe, Claire, Rickinson, Alan

“…Epstein-Barr virus (EBV), a gamma-1 herpesvirus, is carried as a life-long asymptomatic infection by the great majority of individuals in all human…”
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Targeting Macrophages in Cancer: From Bench to Bedside by Poh, Ashleigh R, Ernst, Matthias

“…Macrophages are a major component of the tumor microenvironment and orchestrate various aspects of immunity. Within tumors, macrophages can reversibly alter…”
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Resistance Mechanisms to Anti-angiogenic Therapies in Cancer by Haibe, Yolla, Kreidieh, Malek, El Hajj, Hiba, Khalifeh, Ibrahim, Mukherji, Deborah, Temraz, Sally, Shamseddine, Ali

“…Tumor growth and metastasis rely on tumor vascular network for the adequate supply of oxygen and nutrients. Tumor angiogenesis relies on a highly complex…”
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Long Non-Coding RNAs: The Regulatory Mechanisms, Research Strategies, and Future Directions in Cancers by Gao, Na, Li, Yueheng, Li, Jing, Gao, Zhengfan, Yang, Zhenzhen, Li, Yong, Liu, Hongtao, Fan, Tianli

“…The development and application of whole genome sequencing technology has greatly broadened our horizons on the capabilities of long non-coding RNAs (lncRNAs)…”
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