Search Results - "Frontiers in immunology"

Reduction and Functional Exhaustion of T Cells in Patients With Coronavirus Disease 2019 (COVID-19) by Diao, Bo, Wang, Chenhui, Tan, Yingjun, Chen, Xiewan, Liu, Ying, Ning, Lifen, Chen, Li, Li, Min, Liu, Yueping, Wang, Gang, Yuan, Zilin, Feng, Zeqing, Zhang, Yi, Wu, Yuzhang, Chen, Yongwen

“…The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has posed great threat to human…”
Get full text

Tumor-Associated Macrophages in Tumor Immunity by Pan, Yueyun, Yu, Yinda, Wang, Xiaojian, Zhang, Ting

“…Tumor-associated macrophages (TAMs) represent one of the main tumor-infiltrating immune cell types and are generally categorized into either of two…”
Get full text

The COVID-19 Cytokine Storm; What We Know So Far by Ragab, Dina, Salah Eldin, Haitham, Taeimah, Mohamed, Khattab, Rasha, Salem, Ramy

“…COVID-19 is a rapidly spreading global threat that has been declared as a pandemic by the WHO. COVID-19 is transmitted via droplets or direct contact and…”
Get full text

IOBR: Multi-Omics Immuno-Oncology Biological Research to Decode Tumor Microenvironment and Signatures by Zeng, Dongqiang, Ye, Zilan, Shen, Rongfang, Yu, Guangchuang, Wu, Jiani, Xiong, Yi, Zhou, Rui, Qiu, Wenjun, Huang, Na, Sun, Li, Li, Xuejun, Bin, Jianping, Liao, Yulin, Shi, Min, Liao, Wangjun

“…Recent advances in next-generation sequencing (NGS) technologies have triggered the rapid accumulation of publicly available multi-omics datasets. The…”
Get full text

Short Chain Fatty Acids (SCFAs)-Mediated Gut Epithelial and Immune Regulation and Its Relevance for Inflammatory Bowel Diseases by Parada Venegas, Daniela, De la Fuente, Marjorie K, Landskron, Glauben, González, María Julieta, Quera, Rodrigo, Dijkstra, Gerard, Harmsen, Hermie J M, Faber, Klaas Nico, Hermoso, Marcela A

“…Ulcerative colitis (UC) and Crohn's disease (CD), collectively known as Inflammatory Bowel Diseases (IBD), are caused by a complex interplay between genetic,…”
Get full text

Cytokine Storm in COVID-19: The Current Evidence and Treatment Strategies by Tang, Yujun, Liu, Jiajia, Zhang, Dingyi, Xu, Zhenghao, Ji, Jinjun, Wen, Chengping

“…Severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) is the pathogen that causes coronavirus disease 2019 (COVID-19). As of 25 May 2020, the outbreak…”
Get full text

The Genus Alistipes : Gut Bacteria With Emerging Implications to Inflammation, Cancer, and Mental Health by Parker, Bianca J, Wearsch, Pamela A, Veloo, Alida C M, Rodriguez-Palacios, Alex

“…is a relatively new genus of bacteria isolated primarily from medical clinical samples, although at a low rate compared to other genus members of the phylum,…”
Get full text

The Metabolic Signature of Macrophage Responses by Viola, Antonella, Munari, Fabio, Sánchez-Rodríguez, Ricardo, Scolaro, Tommaso, Castegna, Alessandra

“…Macrophages are a heterogeneous population of immune cells playing several and diverse functions in homeostatic and immune responses. The broad spectrum of…”
Get full text

Macrophage Polarization: Different Gene Signatures in M1(LPS+) vs. Classically and M2(LPS-) vs. Alternatively Activated Macrophages by Orecchioni, Marco, Ghosheh, Yanal, Pramod, Akula Bala, Ley, Klaus

“…Macrophages are found in tissues, body cavities, and mucosal surfaces. Most tissue macrophages are seeded in the early embryo before definitive hematopoiesis…”
Get full text

Cancer Immune Evasion Through Loss of MHC Class I Antigen Presentation by Dhatchinamoorthy, Karthik, Colbert, Jeff D, Rock, Kenneth L

“…Major histocompatibility class I (MHC I) molecules bind peptides derived from a cell's expressed genes and then transport and display this antigenic…”
Get full text

Cancer Stem Cells-Origins and Biomarkers: Perspectives for Targeted Personalized Therapies by Walcher, Lia, Kistenmacher, Ann-Kathrin, Suo, Huizhen, Kitte, Reni, Dluczek, Sarah, Strauß, Alexander, Blaudszun, André-René, Yevsa, Tetyana, Fricke, Stephan, Kossatz-Boehlert, Uta

“…The use of biomarkers in diagnosis, therapy and prognosis has gained increasing interest over the last decades. In particular, the analysis of biomarkers in…”
Get full text

Immune Response, Inflammation, and the Clinical Spectrum of COVID-19 by García, Luis F

“…The current COVID-19 pandemic began in December 2019 in Wuhan (China) and rapidly extended to become a global sanitary and economic emergency. Its etiological…”
Get full text

Role of C-Reactive Protein at Sites of Inflammation and Infection by Sproston, Nicola R, Ashworth, Jason J

“…C-reactive protein (CRP) is an acute inflammatory protein that increases up to 1,000-fold at sites of infection or inflammation. CRP is produced as a…”
Get full text

Toll-Like Receptor Signaling and Its Role in Cell-Mediated Immunity by Duan, Tianhao, Du, Yang, Xing, Changsheng, Wang, Helen Y, Wang, Rong-Fu

“…Innate immunity is the first defense system against invading pathogens. Toll-like receptors (TLRs) are well-defined pattern recognition receptors responsible…”
Get full text

The Tumor Microenvironment: A Milieu Hindering and Obstructing Antitumor Immune Responses by Labani-Motlagh, Alireza, Ashja-Mahdavi, Mehrnoush, Loskog, Angelica

“…The success of cancer immunotherapy relies on the knowledge of the tumor microenvironment and the immune evasion mechanisms in which the tumor, stroma, and…”
Get full text

The Gut-Brain Axis: How Microbiota and Host Inflammasome Influence Brain Physiology and Pathology by Rutsch, Andrina, Kantsjö, Johan B, Ronchi, Francesca

“…The human microbiota has a fundamental role in host physiology and pathology. Gut microbial alteration, also known as dysbiosis, is a condition associated not…”
Get full text

Cold Tumors: A Therapeutic Challenge for Immunotherapy by Bonaventura, Paola, Shekarian, Tala, Alcazer, Vincent, Valladeau-Guilemond, Jenny, Valsesia-Wittmann, Sandrine, Amigorena, Sebastian, Caux, Christophe, Depil, Stéphane

“…Therapeutic monoclonal antibodies targeting immune checkpoints (ICPs) have changed the treatment landscape of many tumors. However, response rate remains…”
Get full text

A Review of the Progress and Challenges of Developing a Vaccine for COVID-19 by Sharma, Omna, Sultan, Ali A, Ding, Hong, Triggle, Chris R

“…A novel coronavirus, which has been designated as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was first detected in December 2019 in Wuhan…”
Get full text

Anti-Inflammatory and Immunomodulatory Effects of Probiotics in Gut Inflammation: A Door to the Body by Cristofori, Fernanda, Dargenio, Vanessa Nadia, Dargenio, Costantino, Miniello, Vito Leonardo, Barone, Michele, Francavilla, Ruggiero

“…Hosting millions of microorganisms, the digestive tract is the primary and most important part of bacterial colonization. On one side, in cases of…”
Get full text

The C/EBP Homologous Protein (CHOP) Transcription Factor Functions in Endoplasmic Reticulum Stress-Induced Apoptosis and Microbial Infection by Hu, Hai, Tian, Mingxing, Ding, Chan, Yu, Shengqing

“…Apoptosis is a form of cell death by which the body maintains the homeostasis of the internal environment. Apoptosis is an initiative cell death process that…”
Get full text