Search Results - "Frontiers in genetics"

The Potential for microRNA Therapeutics and Clinical Research by Hanna, Johora, Hossain, Gazi S, Kocerha, Jannet

“…As FDA-approved small RNA drugs start to enter clinical medicine, ongoing studies for the microRNA (miRNA) class of small RNAs expand its preclinical and…”
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Ethanol-Induced Behavioral Sensitization Alters the Synaptic Transcriptome and Exon Utilization in DBA/2J Mice by O'Brien, Megan A, Weston, Rory M, Sheth, Nihar U, Bradley, Steven, Bigbee, John, Pandey, Ashutosh, Williams, Robert W, Wolstenholme, Jennifer T, Miles, Michael F

“…Alcoholism is a complex behavioral disorder characterized by loss of control in limiting intake, and progressive compulsion to seek and consume ethanol. Prior…”
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Single-Cell RNA-Seq Technologies and Related Computational Data Analysis by Chen, Geng, Ning, Baitang, Shi, Tieliu

“…Single-cell RNA sequencing (scRNA-seq) technologies allow the dissection of gene expression at single-cell resolution, which greatly revolutionizes…”
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Review of Causal Discovery Methods Based on Graphical Models by Glymour, Clark, Zhang, Kun, Spirtes, Peter

“…A fundamental task in various disciplines of science, including biology, is to find underlying causal relations and make use of them. Causal relations can be…”
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Predicting Diabetes Mellitus With Machine Learning Techniques by Zou, Quan, Qu, Kaiyang, Luo, Yamei, Yin, Dehui, Ju, Ying, Tang, Hua

“…Diabetes mellitus is a chronic disease characterized by hyperglycemia. It may cause many complications. According to the growing morbidity in recent years, in…”
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Regulation of Mitochondrial Biogenesis as a Way for Active Longevity: Interaction Between the Nrf2 and PGC-1α Signaling Pathways by Gureev, Artem P, Shaforostova, Ekaterina A, Popov, Vasily N

“…Aging is a general degenerative process related to deterioration of cell functions in the entire organism. Mitochondria, which play a key role in energy…”
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Graph Neural Networks and Their Current Applications in Bioinformatics by Zhang, Xiao-Meng, Liang, Li, Liu, Lin, Tang, Ming-Jing

“…Graph neural networks (GNNs), as a branch of deep learning in non-Euclidean space, perform particularly well in various tasks that process graph structure…”
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From GWAS to Function: Using Functional Genomics to Identify the Mechanisms Underlying Complex Diseases by Cano-Gamez, Eddie, Trynka, Gosia

“…Genome-wide association studies (GWAS) have successfully mapped thousands of loci associated with complex traits. These associations could reveal the molecular…”
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DNA Methylation Cancer Biomarkers: Translation to the Clinic by Locke, Warwick J, Guanzon, Dominic, Ma, Chenkai, Liew, Yi Jin, Duesing, Konsta R, Fung, Kim Y C, Ross, Jason P

“…Carcinogenesis is accompanied by widespread DNA methylation changes within the cell. These changes are characterized by a globally hypomethylated genome with…”
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Circulating MicroRNAs in Cancer: Potential and Challenge by Cui, Mengying, Wang, Hongdan, Yao, Xiaoxiao, Zhang, Dan, Xie, Yingjun, Cui, Ranji, Zhang, Xuewen

“…MicroRNAs (miRNAs) are endogenous non-coding small RNA molecules that can be secreted into the circulation and exist in remarkably stable forms. Like…”
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Telomere Length as a Marker of Biological Age: State-of-the-Art, Open Issues, and Future Perspectives by Vaiserman, Alexander, Krasnienkov, Dmytro

“…Telomere shortening is a well-known hallmark of both cellular senescence and organismal aging. An accelerated rate of telomere attrition is also a common…”
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ggVennDiagram: An Intuitive, Easy-to-Use, and Highly Customizable R Package to Generate Venn Diagram by Gao, Chun-Hui, Yu, Guangchuang, Cai, Peng

“…Venn diagrams are widely used diagrams to show the set relationships in biomedical studies. In this study, we developed ggVennDiagram, an R package that could…”
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Long-Read Sequencing Emerging in Medical Genetics by Mantere, Tuomo, Kersten, Simone, Hoischen, Alexander

“…The wide implementation of next-generation sequencing (NGS) technologies has revolutionized the field of medical genetics. However, the short read lengths of…”
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GNB3 c.825c>T polymorphism influences T-cell but not antibody response following vaccination with the mRNA-1273 vaccine by Čiučiulkaitė, Ieva, Möhlendick, Birte, Thümmler, Laura, Fisenkci, Neslinur, Elsner, Carina, Dittmer, Ulf, Siffert, Winfried, Lindemann, Monika

“…Background: Immune responses following vaccination against COVID-19 with different vaccines and the waning of immunity vary within the population. Genetic host…”
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Digital Twins in Health Care: Ethical Implications of an Emerging Engineering Paradigm by Bruynseels, Koen, Santoni de Sio, Filippo, van den Hoven, Jeroen

“…Personalized medicine uses fine grained information on individual persons, to pinpoint deviations from the normal. 'Digital Twins' in engineering provide a…”
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Advances and Challenges in Metatranscriptomic Analysis by Shakya, Migun, Lo, Chien-Chi, Chain, Patrick S. G.

“…Sequencing-based analyses of microbiomes have traditionally focused on addressing the question of community membership and profiling taxonomic abundance…”
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Use ggbreak to Effectively Utilize Plotting Space to Deal With Large Datasets and Outliers by Xu, Shuangbin, Chen, Meijun, Feng, Tingze, Zhan, Li, Zhou, Lang, Yu, Guangchuang

“…With the rapid increase of large-scale datasets, biomedical data visualization is facing challenges. The data may be large, have different orders of magnitude,…”
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pathfindR: An R Package for Comprehensive Identification of Enriched Pathways in Omics Data Through Active Subnetworks by Ulgen, Ege, Ozisik, Ozan, Sezerman, Osman Ugur

“…Pathway analysis is often the first choice for studying the mechanisms underlying a phenotype. However, conventional methods for pathway analysis do not take…”
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Biomarkers of Cellular Senescence and Skin Aging by Wang, Audrey S, Dreesen, Oliver

“…Cellular senescence is an irreversible growth arrest that occurs as a result of different damaging stimuli, including DNA damage, telomere shortening and…”
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Nanoparticle Delivery of CRISPR/Cas9 for Genome Editing by Duan, Li, Ouyang, Kan, Xu, Xiao, Xu, Limei, Wen, Caining, Zhou, Xiaoying, Qin, Zhuan, Xu, Zhiyi, Sun, Wei, Liang, Yujie

“…The emerging clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated system (Cas) gene-editing system represents a promising tool…”
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